초록

The invention describes nanotextured super hydrophobic coatings that contain active agents which can elute from the coating over a period of time.

대표청구항 ▼

1. A superhydrophobic coating comprising: a first hydrophobic binder;a plurality of particles comprising a size between about 1 nm to about 25 microns;a bioactive agent, anda crosslinker, wherein the crosslinker has a formula: L-(T-C(R1)(XP)CHR2GR3C(═O)R4)m wherein L is a linking group, comprising t

1. A superhydrophobic coating comprising: a first hydrophobic binder;a plurality of particles comprising a size between about 1 nm to about 25 microns;a bioactive agent, anda crosslinker, wherein the crosslinker has a formula: L-(T-C(R1)(XP)CHR2GR3C(═O)R4)m wherein L is a linking group, comprising the formula according to structure (I): wherein A and J are each independently a hydrogen atom, an alkyl group, an aryl group, or together with B form a cyclic ring, provided when A and J are each independently a hydrogen atom, an alkyl group, or an aryl group then B is not present; B is NR11, O, or (—CH2—)z;provided when A, B and J form a ring, then A and J are (—CH2—)z, or C═O;R11 is a hydrogen atom, an alkyl group, an aryl group or denotes a bond with Teach z independently is an integer from 0 to 3; andprovided when either A or J is C═O, then B is NR11, O, or (—CH2—)z and z must be at least 1;T is (—CH2—)x,(—CH2CH2—O—)x,(—CH2CH2CH2—O—)x,(—CH2CH2CH2CH2—O—)x or forms a bond;R1 is a hydrogen atom, an alkyl, alkyloxyalkyl, aryl, aryloxyalkyl or aryloxyaryl group;X is O, S, or NR8R9;P is a hydrogen atom or a protecting group, with the proviso that P is absent when X is NR8R9;R2 is a hydrogen atom, an alkyl, alkyloxyalkyl, aryl, aryloxyalkyl or aryloxyaryl group;G is O, S, SO, SO2, NR10,(CH2)t—O— or C═O;R3 and R4 are each independently an alkyl, aryl, arylalkyl, heteroaryl, or an heteroarylalkyl group, or optionally, R3 and R4 can be tethered together via (—CH2—)q,(—CH2—)rC═O(—CH2—)s,(—CH2—)rS(—CH2—)s,(—CH2—),rS═O(—CH2—)s or(—CH2—)rS(O)2(—CH2—)s,(—CH2—)rNR(—CH2—)s;R10 is a hydrogen atom or an alkyl, aryl or arylalkyl group;R8 and R9 are each independently a hydrogen atom, an alkyl, aryl, or arylalkyl group;R is a hydrogen atom, an alkyl or aryl group;q is an integer from 1 to about 7;r is an integer from 0 to about 3;s is an integer from 0 to about 3;m is an integer from 2 to about 10;t is an integer from 1 to about 10; andx is an integer from 1 to about 500. 2. The coating of claim 1, wherein the particles are dispersed throughout the bulk of the coating. 3. The coating of claim 1, wherein the particles are present in a weight ratio of particles to polymeric binder of 1:1 to 4:1. 4. The coating of claim 1, further comprising an initiator. 5. The coating of claim 1, wherein the hydrophobic polymeric binder has a surface tension of less than about 50 mN/m. 6. The coating of claim 1, wherein the hydrophobic binder is a hydrophobic polymer that is a homopolymer or copolymer of a polyalkylene, a polyacrylate, a polymethacrylate, a polyester, a polyamide, a polyurethane, a polyvinylarylene, a polyvinyl ester, a polyvinylarylene/alkylene copolymer, a polyalkyleneoxide, a polyvinyl halide, or mixtures thereof. 7. The coating of claim 4, wherein the crosslinker has more than one acrylate, methacrylate, vinyl or arylketone containing moiety. 8. The coating of claim 4, wherein the initiator, when present, is benzophenone, an acetophenone derivative, a peroxide, a peroxy compound, a benzoin derivative, a benzilketal, a hydroxyalkylphenone, an aminoalkylphenone, an O-acyl oximoketone, an acylphosphine oxides, an acylphosphonate, a thiobenzoic S-ester, an azo or azide compound, a triazine, a 1,2 diketone, a quinone, a coumarins, a xanthone, azobis-isobutyronitrile or a mixture thereof. 9. The coating of claim 1, wherein the particles are aluminum oxides, titanium oxide, zirconium oxide, organothiolated gold, organothiolated silver, silanated silver, nickel, nickel oxide, iron oxide, polystyrene particles, (meth)acrylates particles, polytetrafluroethylene particles, silica particles, polyolefin particles, polycarbonate particles, polysiloxane particles, silicone particles, polyester particles, polyamide particles, polyurethane particles, ethylenically unsaturated polymer particles, polyanhydride particles, polycaprolactone (PCL), polylactideglycolide (PLGA), nanofibers, nanotubes, or nanowires, or combinations thereof. 10. The coating of claim 1, wherein the bioactive agent is an anti-inflammatory, an antimicrobial or an antibiotic. 11. A composite comprising: a substrate; andthe coating of claim 1 coated onto the substrate.