Systems, devices and methods relating to endocardial pacing for resynchronization
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-001/362
A61N-001/36
A61N-001/368
A61N-001/05
출원번호
US-0223919
(2011-09-01)
등록번호
US-8825155
(2014-09-02)
우선권정보
AR-20040104782 (2004-12-20)
발명자
/ 주소
Zhu, Qingsheng
Ortega, Daniel Felipe
출원인 / 주소
Cardiac Pacemakers, Inc.
대리인 / 주소
Schwegman Lundberg & Woessner, P.A.
인용정보
피인용 횟수 :
2인용 특허 :
141
초록▼
Disclosed are certain methods, apparatus, and processor-readable mediums that may be used to treat a conduction abnormality of the heart. In one example, the apparatus includes an implantable pacing profile generator configured to generate a specified pacing electrostimulation profile for delivery t
Disclosed are certain methods, apparatus, and processor-readable mediums that may be used to treat a conduction abnormality of the heart. In one example, the apparatus includes an implantable pacing profile generator configured to generate a specified pacing electrostimulation profile for delivery to a heart via electrodes located near a septal region of the right ventricle of the heart near the His bundle, the pacing profile including a first pulse for delivery via a first electrode; and a second pulse for delivery via a second electrode; and wherein the first and second pulses are at least partially concurrent in time and opposite in polarity to each other.
대표청구항▼
1. An apparatus, comprising: an implantable pacing profile generator configured to generate a specified pacing electrostimulation profile for delivery to a heart via electrodes located near a septal region of the right ventricle of the heart near the His bundle, the pacing profile including: a first
1. An apparatus, comprising: an implantable pacing profile generator configured to generate a specified pacing electrostimulation profile for delivery to a heart via electrodes located near a septal region of the right ventricle of the heart near the His bundle, the pacing profile including: a first pulse for delivery via a first electrode located near the septal region of the right ventricle of the heart near the His bundle; anda second pulse for delivery via a second electrode located near the septal region of the right ventricle of the heart near the his bundle,wherein the first and second pulses are at least partially concurrent in time and opposite in polarity to each other; andwherein the implantable pacing profile generator is configured to update an overlap duration of the first and second pulses using a measured effectiveness of a previous electrostimulation provided to the heart via the first and second electrodes located near the septal region of the right ventricle of the heart near the His bundle. 2. The apparatus of claim 1, wherein the implantable pacing profile generator is configured to use, as the measured effectiveness of the previous electrostimulation, information about one or more of: a QRS width, an electrogram fractionation, a late LV activation timing, a mechanical synchronicity of a free wall and a septal wall, or an effective throughput. 3. The apparatus of claim 1, wherein the first and second pulses are substantially identical in time and duration. 4. The apparatus of claim 1, further comprising an implantable lead assembly including the first electrode and the second electrode. 5. The apparatus of claim 1, wherein the pacing profile generator includes a wireless interface configured to receive a command to adjust one or more parameters of the pacing profile from an external device in response to monitored information indicative of one or more of: a QRS width, an electrogram fractionation, a late LV activation timing, a mechanical synchronicity of a free wall and a septal wall, or an effective throughput, wherein the one or more adjustable parameters include one or more of a pulse width, a pulse amplitude, or a timing offset between initiation or termination of respective pulses. 6. The apparatus of claim 1, comprising a measurement module configured to measure the effectiveness of the previous electrostimulation provided to the heart, the measured effectiveness including a function of a timing of stimulation of a late activation site of a left ventricle relative to the QRS width. 7. The apparatus of claim 1, wherein the implantable pacing profile generator is configured to generate the pulses of the specified pacing electrostimulation profile at an energy level that exceeds a capture threshold voltage level of the His bundle. 8. A method, comprising: generating a specified pacing electrostimulation profile for delivery to a heart via first and second electrodes located near a septal region of the right ventricle of the heart near the His bundle, the pacing profile including: a first pulse for delivery via the first electrode; anda second pulse for delivery via the second electrode,wherein the first and second pulses are at least partially concurrent in time and opposite in polarity to each other;assessing an effectiveness of an electrostimulation provided to the heart using the first and second electrodes according to the specified pacing electrostimulation profile, the assessing including identifying a function of a timing of stimulation of a late activation site of a left ventricle relative to the QRS width; andupdating, for a subsequent pacing electrostimulation profile, an energy of at least one of the first and second pulses using the assessed effectiveness. 9. The method of claim 8, wherein the assessing the effectiveness of the electrostimulation provided to the heart using the first and second electrodes includes monitoring one or more of a QRS width, an electrogram fractionation, a late LV activation timing, a mechanical synchronicity of a free wall and a septal wall, or an effective throughput. 10. The method of claim 8, wherein the first and second pulses are substantially identical in time and duration. 11. The method of claim 8, comprising receiving, at an implantable medical device, a command to adjust one or more parameters of the pacing profile, the command provided from an external device using a wireless interface. 12. The method of claim 11, wherein the one or more adjustable parameters include one or more of a pulse width, a pulse amplitude, or a timing offset between initiation or termination of respective pulses. 13. The method of claim 8, comprising adjusting one or more of the adjustable parameters to improve at least one of: a QRS width, an electrogram fractionation, a late LV activation timing, a mechanical synchronicity of a free wall and a septal wall, or an effective throughput. 14. The method of claim 8, comprising updating, for the subsequent pacing electrostimulation profile, an overlap duration of the first and second pulses, using the assessed effectiveness. 15. The method of claim 8, wherein the updating the energy includes using a pacing voltage threshold that exceeds a His bundle capture threshold. 16. A processor-readable medium comprising instructions, which when executed by a processor included as a portion of an implantable medical device cause the implantable medical device to: generate a specified pacing electrostimulation profile for delivery to a heart via first and second electrodes located near a septal region of the right ventricle of the heart near the His bundle, the pacing profile including: a first pulse for delivery via the first electrode; anda second pulse for delivery via the second electrode,wherein the first and second pulses are at least partially concurrent in time and opposite in polarity to each other;assess an effectiveness of an electrostimulation provided to the heart using the first and second electrodes and using the specified pacing electrostimulation profile, the assessment including a function of a timing of stimulation of a late activation site of a left ventricle relative to the QRS width; andupdate, for a subsequent pacing electrostimulation profile, an overlap duration of the first and second pulses using the assessed effectiveness. 17. The processor-readable medium of claim 16, wherein the instructions include instructions that cause the implantable medical device to use, in assessing the effectiveness of the electrostimulation, information about one or more of: a QRS width, an electrogram fractionation, a late LV activation timing, a mechanical synchronicity of a free wall and a septal wall, or an effective throughput. 18. The processor-readable medium of claim 17, wherein the first and second pulses are substantially identical in time and duration. 19. The processor-readable medium of claim 18, wherein the instructions include instructions that cause the implantable medical device to receive a command to adjust one or more parameters of the pacing profile, the command provided from an external device using a wireless interface, wherein the one or more adjustable parameters include one or more of a pulse width, a pulse amplitude, or a timing offset between initiation or termination of respective pulses. 20. The processor-readable medium of claim 16, wherein the instructions include instructions that cause the implantable medical device to update, for the subsequent pacing electrostimulation profile, an energy of at least one of the first and second pulses, using the assessed effectiveness.
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이 특허에 인용된 특허 (141)
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