A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes a self-purging preservation apparatus to suspend the sample in preservation fluid, and perfuse a tissue with preservation fluid. The self-purging preservation apparatus is place
A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes a self-purging preservation apparatus to suspend the sample in preservation fluid, and perfuse a tissue with preservation fluid. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature, while self-purging trapped gases.
대표청구항▼
1. A system for hypothermic transport of a biological sample, comprising: a self-purging preservation apparatus comprising an organ chamber and a lid assembly configured to seal against the organ chamber, the lid assembly comprising pumping chamber, a fill port, a valve, and a purge port, the pumpin
1. A system for hypothermic transport of a biological sample, comprising: a self-purging preservation apparatus comprising an organ chamber and a lid assembly configured to seal against the organ chamber, the lid assembly comprising pumping chamber, a fill port, a valve, and a purge port, the pumping chamber comprising a semi-permeable membrane that is disposed in the lid assembly at an inclined angle with respect to a horizontal axis and capable of exerting a force against a preservation fluid contacting a first side of the semi-permeable membrane when a pressure is applied against a second side of the semi-permeable membrane,the fill port coupled to a first lumen and providing a direct fluidic path between the organ chamber and an exterior of the system,the valve providing a fluidic path between a highest point of the organ chamber and the first side of the semi-permeable membrane, andthe purge port providing a fluidic path from a highest point of the first side of the semi-permeable membrane to an exterior of the apparatus,wherein the apparatus is adapted to expel a rising fluid from the apparatus via the purge port when the organ chamber is sealed to the lid assembly and filled with liquid via the fill port; andan insulated transport container for receiving the self-purging preservation apparatus and cooling media. 2. The system of claim 1, wherein the self-purging preservation apparatus comprises a temperature sensor. 3. The system of claim 1, further comprising an oxygen source operably coupled to the self-purging preservation apparatus. 4. The system of claim 3, wherein the oxygen source is a compressed gas cylinder. 5. The system of claim 1, wherein the cooling media comprises eutectic cooling packs. 6. The system of claim 1, wherein the biological sample comprises tissues or organs. 7. The system of claim 1, wherein the biological sample is a container holding body fluids. 8. The system of claim 2, wherein the system comprises a temperature display. 9. The system of claim 8, wherein the temperature display communicates with the temperature sensor wirelessly. 10. The system of claim 1, wherein the self-purging preservation apparatus additionally comprises a pressure sensor. 11. The system of claim 10, wherein the system comprises a pressure display. 12. The system of claim 1, wherein the self-purging preservation apparatus additionally comprises an oxygen sensor capable of measuring a partial pressure of oxygen in a fluid within the self-purging preservation apparatus. 13. The system of claim 12, wherein the system comprises an oxygen display. 14. The system of claim 1, wherein the inclined angle is 1°-10° with respect to the horizontal axis. 15. The system of claim 1, wherein the valve is a check valve. 16. The system of claim 1, further comprising an organ adapter comprising a second lumen, coupled to the lid assembly, and in fluid communication with the first side of the semi-permeable membrane. 17. The system of claim 16, wherein when an organ is coupled to the organ adapter coupled to the lid assembly, and a fluid is delivered to the fill port, the fluid can pass from the fill port to the organ chamber without passing through the organ. 18. The system of claim 1, further comprising a pneumatic control system in fluid communication with the second side of the semi-permeable membrane. 19. The system of claim 18, further comprising a supply line configured to deliver a compressed gas to the pneumatic control system, thereby allowing the pneumatic control system to deliver a compressed gas to the second side of the semi-permeable membrane. 20. The system of claim 18, further comprising a vent line configured to allow the pneumatic control system to release a vent gas from the second side of the semi-permeable membrane. 21. The system of claim 1, wherein the first lumen does not contact or traverse the semi-permeable membrane.
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