초록 ▼

A bioactive PMMA (polymethylmethacrylate) bone cement contains a powder component and a reactive monomer liquid, wherein the powder component and the reactive monomer liquid when mixed with one another react with one another and form a polymer-based solid material. The powder component contains part

A bioactive PMMA (polymethylmethacrylate) bone cement contains a powder component and a reactive monomer liquid, wherein the powder component and the reactive monomer liquid when mixed with one another react with one another and form a polymer-based solid material. The powder component contains particulate polymer powder of polymethylmethacrylates; a radical starter; and anionic copolymer nanoparticles. The anionic copolymer nanoparticles are distributed in nano-particulate form within the particulate powder component or coated as a film on particles of the particulate polymer powder.

대표청구항 ▼

1. A bioactive PMMA (polymethylmethacrylate) bone cement comprising: a powder component comprising: particulate polymer powder of polymethylmethacrylates;a radical starter; andanionic copolymer nanoparticles consisting of anionic co-oligomers or of anionic copolymers, wherein the anionic co-oligomer

1. A bioactive PMMA (polymethylmethacrylate) bone cement comprising: a powder component comprising: particulate polymer powder of polymethylmethacrylates;a radical starter; andanionic copolymer nanoparticles consisting of anionic co-oligomers or of anionic copolymers, wherein the anionic co-oligomers or anionic copolymers consist of first monomer units that are selected from the group consisting of acrylate, methacrylate, styrene, vinyl monomers, and monomers with ethylenically unsaturated double bond, and of second monomer units with free anionic groups or anionic groups that dissociate or hydrolyze when in contact with an aqueous solution, the anionic groups selected from the group consisting of carboxyl, phosphate, phosphonate, and sulfate, wherein the anionic copolymer nanoparticles are distributed in nano-particulate form within the powder component or coated as a film on particles of the particulate polymer powder;a reactive monomer liquid;wherein when the powder component and the reactive monomer liquid are mixed with each other, the anionic copolymer nanoparticles dissolve quickly in the reactive monomer and the powder component and the reactive monomer react with one another and form a polymer-based solid material. 2. The bone cement according to claim 1, wherein the anionic copolymer nanoparticles are present as nano-particulate coatings on the particulate polymer powder. 3. The bone cement according to claim 1, wherein the anionic copolymer nanoparticles have a size of 30 nm to 5,000 nm. 4. The bone cement according to claim 1, wherein the second monomer units are present in a molar proportion of 0.01% to 25%. 5. The bone cement according to claim 1, wherein the proportion of the anionic copolymer nanoparticles in the powder component is 0.1% to 50% by weight. 6. The bone cement according to claim 1, wherein a proportion of the anionic copolymers is not crosslinked. 7. The bone cement according to claim 1, wherein the powder component further comprises non-anionic copolymer nanoparticles. 8. The bone cement according to claim 1, further comprising a carrier liquid, wherein the powder component is combined with the carrier liquid to a storage-stable paste. 9. The bone cement according to claim 1, wherein the powder component further comprises at least one additive selected from the group consisting of water-soluble calcium salts, biocompatible buffering substances, x-ray contrast agents, antibiotics, antimicrobial agents, and anti-inflammatory agents. 10. The bone cement according to claim 1, formulated in a mixing system wherein the powder component and the reactive monomer liquid are contained in spatially separate containers. 11. The bone cement according to claim 10, wherein the mixing system is a ready-made system in sterilized form. 12. The bone cement according to claim 1 in the form of a kit comprised of two or more separately packaged components containing the powder component and the reactive monomer liquid, respectively, wherein the packaged components are matched to one another in regard to quantity ratios and are combined with one another not until immediately before use. 13. The bone cement according to claim 1 as an anchoring cement for prosthesis components in the bone, as a cement for reinforcing bone, as a cement for filling and reconstructing bone defects of all kinds, as a dowel for bone screws, and as implant material for anchoring screws and other implants for osteosynthesis. 14. The bone cement according to claim 1, wherein the powder component further comprises at least one additive for increasing mineralization, the at least one additive selected from the group consisting of water-soluble calcium salts and biocompatible buffering substances.