Oral treatment compositions and related methods of manufacture
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-008/365
A61P-001/02
A61Q-011/00
A61K-008/34
A61K-008/04
A61K-008/25
출원번호
US-0370845
(2009-02-13)
등록번호
US-8834854
(2014-09-16)
발명자
/ 주소
Fisher, Jeffrey J.
Soliz, Debra C.
출원인 / 주소
Ranir, LLC
대리인 / 주소
Warner Norcross & Judd LLP
인용정보
피인용 횟수 :
0인용 특허 :
12
초록▼
An oral treatment composition that includes a carrier, an active agent and a silicon dioxide compound. The active agent can be a variety of compositions, such as dental whitening or bleaching agents, desensitizing agents, antimicrobials, anti-plaque agents, remineralizing agents, anti-tartar agents,
An oral treatment composition that includes a carrier, an active agent and a silicon dioxide compound. The active agent can be a variety of compositions, such as dental whitening or bleaching agents, desensitizing agents, antimicrobials, anti-plaque agents, remineralizing agents, anti-tartar agents, mouth fresheners, and anesthetics. Optionally, a processing aid can be added to the composition to streamline manufacture of the gel. The composition can be formed as a bead in a dental tray so that when a user applies the dental tray to their dental arch, the bead readily spreads over the surfaces of the teeth without the user having to supply significant force to achieve such spreading.
대표청구항▼
1. An oral treatment composition associated with a dental tray comprising: an orally administrable matrix including a carrier, an active agent, a processing aid, and a silicon dioxide, said orally administrable matrix in the form of a bead;a dental tray, said bead of orally administrable matrix disp
1. An oral treatment composition associated with a dental tray comprising: an orally administrable matrix including a carrier, an active agent, a processing aid, and a silicon dioxide, said orally administrable matrix in the form of a bead;a dental tray, said bead of orally administrable matrix disposed in the dental tray;wherein said matrix forms a tacky, spreadable gel having a viscosity of between about 4,000 Pa·s and about 2,000 Pa·s;wherein said active agent is hydrogen peroxide that functions as a whitening agent;wherein the orally administrable matrix is substantially free of hydrophilic polymers, including being substantially free of polyvinyl pyrrolidone;wherein the orally administrable matrix includes about 5% to about 40% water by weight of the oral treatment composition;wherein said silicon dioxide is present in a range from 4% to 10% by weight of the oral treatment composition;wherein said bead is adapted for application to a dental arch of a subject by application of the dental tray containing the bead to the dental arch of the subject;wherein said viscosity enables the active agent of said orally administrable matrix to be maintained in close proximity to surfaces and interproximal spaces between adjacent teeth of the subject. 2. The oral treatment composition of claim 1, wherein said carrier is selected from the group consisting of glycerin, sorbitol, mannitol, sugar alcohols, and 1,3-propanediol. 3. The oral treatment composition of claim 1, wherein said carrier is present in a range from about 30% to about 80% by weight of the oral treatment composition. 4. The oral treatment composition of claim 1, wherein said active agent is present in a range from about 1% to about 20% by weight of the oral treatment composition. 5. The oral treatment composition of claim 1, wherein said silicon dioxide is selected from the group consisting of silica in powdered form, crystalline form, and fumed form. 6. The oral treatment composition of claim 1, wherein said silicon dioxide is present in an amount of about 8% by weight of the oral treatment composition. 7. The oral treatment composition of claim 1, wherein the processing aid is a polysorbate surfactant, wherein the polysorbate surfactant and the silicon dioxide are mixed in a ratio of about 0.02:0.3 (polysorbate surfactant:silicon dioxide). 8. The oral composition of claim 1, wherein the processing aid is a surfactant selected from the group consisting of polysorbate 20, polysorbate 60, polysorbate 80, polyoxyethylene derivatives of sorbitan monolaurate, a polaxamer, polyoxyproplylene derivatives, sodium monolaurate, laureth-6 carboxylic acid, and combinations thereof. 9. A method of forming the oral treatment composition of claim 1, comprising: providing a carrier;adding an active agent;adding a silicon dioxide component, wherein the carrier, active agent, and silicon dioxide components form a thin, viscous, liquid solution; andadding a processing aid to the liquid solution after the liquid solution including the carrier, active agent, and silicon dioxide is formed, wherein the processing aid reacts with the liquid solution to create a matrix of the carrier, active agent and silicon dioxide so that the resulting oral treatment composition is in the form of the tacky, readily spreadable viscous gel. 10. A method of forming the oral treatment composition of claim 1, comprising: preparing a first part including a mixture of a carrier and a silicon dioxide;separately preparing a second part including a mixture of a silicon dioxide and an active agent; andmixing the first part and the second part together after the first part and second part are prepared to form the oral treatment composition, which is in the form of the tacky, readily spreadable viscous gel. 11. A method of using the oral treatment composition of claim 1 comprising: providing the orally administrable matrix in the form of a bead disposed in a dental tray;applying the dental tray to a dental arch of a subject so the orally administrable matrix spreads over a plurality of teeth as the dental tray is applied, wherein a shear rate of the matrix between the plurality of teeth and the dental tray is 0.01 l/sec to 0.1 l/sec as the dental tray is applied; andretaining the dental tray adjacent the dental arch for 10 minutes or longer to promote a whitening effect on the plurality of teeth;wherein said orally administrable matrix is substantially free of hydrophilic polymers, wherein said silicon dioxide is present in a range from 3% to 16% by weight of the orally administrable matrix, and wherein said orally administrable matrix is in the form of a bead disposed in a dental tray. 12. The oral treatment composition of claim 1 comprising; water present in an amount of about 15% to about 35%;a polysorbate surfactant present in an amount of about 0.1% to about 2.75% by weight of the oral treatment composition;an acid present in an amount of about 1.0% to about 5.0% by weight of the oral treatment composition,flavoring present in an amount of about 0.1% to about 5% by weight of the oral treatment composition; anda stabilizer present in an amount of about 0.1% to about 5% by weight of the oral treatment composition,wherein said carrier includes glycerin present in an amount of about 45% to about 65% by weight of the oral treatment composition,wherein said hydrogen peroxide is present in an amount of about 5% to about 20% by weight of the oral treatment composition. 13. The oral treatment composition of claim 12, wherein the glycerin is present in an amount of 55.05% by weight of the oral treatment composition,wherein the water is present in an amount of 19.50% by weight of the oral treatment composition,wherein the polysorbate surfactant is present in an amount of 1.68% by weight of the oral treatment composition,wherein the hydrogen peroxide is present in an amount of 10.50% by weight of the oral treatment composition;wherein the silica dioxide is present in an amount of 8% by weight of the oral treatment composition,wherein the acid is citric acid present in an amount of 1.14% by weight of the oral treatment composition,wherein the flavoring is present in an amount of 0.80% by weight of the oral treatment composition,wherein the stabilizer is xanthan gum present in an amount of 0.75% by weight of the oral treatment composition. 14. The oral treatment composition of claim 1, wherein the gel is spreadable at a shear rate of between about 0.01 l/sec to about 1 l/sec. 15. The oral treatment composition of claim 1, wherein the composition provides a delta whitening on a shade scale of between about 3.02 and about 3.13.
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이 특허에 인용된 특허 (12)
Fontenot Mark G. (229 Marilyn Dr. Lafayette LA 70503), Apparatus and method for lightening teeth.
Allred, Peter M.; Fischer, Dan E., Oral treatment devices that include a thin, flexible barrier layer and an endoskeleton treatment or adhesive composition.
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