Antiseptic compositions, as well as methods of making and using, wherein the compositions include: an antimicrobial agent selected from the group consisting of iodine (I2), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an availa
Antiseptic compositions, as well as methods of making and using, wherein the compositions include: an antimicrobial agent selected from the group consisting of iodine (I2), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least about 0.25 wt-%; a hydroxycarboxylic acid buffer in an amount of at least about 5 wt-%; water; and an optionally substantive film-forming polymer.
대표청구항▼
1. A method of disinfecting tissue comprising: applying directly to tissue an antiseptic composition at use concentration, wherein the use concentration of the composition comprises: an antimicrobial agent selected from the group consisting of I2, an iodophor, and a combination thereof, wherein the
1. A method of disinfecting tissue comprising: applying directly to tissue an antiseptic composition at use concentration, wherein the use concentration of the composition comprises: an antimicrobial agent selected from the group consisting of I2, an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least 0.25 wt-%;a hydroxycarboxylic acid in an amount in excess of 5 wt-%;an anionic or amphoteric surfactant; andwater; andallowing the antiseptic composition to remain on the tissue;wherein the composition has a pH of 3 to 4. 2. The method of claim 1 wherein the antiseptic composition further includes a film-forming polymer. 3. The method of claim 2 wherein the film-forming polymer is substantive. 4. The method of claim 1: wherein the composition further comprises a substantive film-forming polymer; andwherein a dry film of the composition is stable and substantive. 5. The method of claim 1 wherein the composition further comprises a film-forming polymer comprising hydrophilic and hydrophobic moieties. 6. The method of claim 1: wherein the composition further comprises a substantive film-forming polymer; andwherein a dry film of the composition is stable and substantive; andwherein the composition demonstrates one or more of the following characteristics: reduces normal skin flora by at least about 1 log in 2 minutes on a dry human skin site using ASTM testing method E1173-93 and a 30-second scrub with gauze soaked in the composition using moderate pressure;is substantially nontacky when in the form of a dry film;demonstrates a Draize score of zero in no greater than about 96 hours according to the Rabbit Eye Irritation Test; oradheres to a PSA-coated tape at a level of at least about 50% of the level of adhesion of the PSA-coated tape applied over dried BETADINE surgical scrub and paint solutions when measured using a 180 degree peel test after applying the PSA-coated tape to a dry film on dry human skin by rolling with a 2.1-kg, 5.1-cm wide roller, waiting at least 1 minute, and removing the PSA-coated tape at a peel angle of 180 degrees at a speed of 30.5 cm/minute. 7. The method of claim 6 wherein a dry film of the composition is stable and substantive and reduces normal skin flora by at least about 1 log in 2 minutes on a dry human skin site using ASTM testing method E1173-93 and a 30-second scrub with gauze soaked in the composition using moderate pressure. 8. The method of claim 1 wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least 0.25 wt-% and not more than about 1.5 wt-%. 9. The method of claim 1 wherein the surfactant is a quaternary amine containing zwitterionic surfactant. 10. A method of disinfecting tissue comprising: applying directly to tissue an antiseptic composition at use concentration, wherein the use concentration of the composition comprises: an iodophor comprising a carrier selected from the group consisting of a polyvinylpyrrolidone, a copolymer of N-vinyl lactam, a polyether glycol, a polyvinyl alcohol, a polyacrylamide, a polysaccharide, and combinations thereof; wherein the iodophor is present in an amount sufficient to provide an available iodine concentration of at least 0.25 wt-%;a hydroxycarboxylic acid buffer in an amount in excess of 5 wt-%;an anionic or amphoteric surfactant; andwater; andallowing the antiseptic composition to remain on the tissue;wherein the composition has a pH of 3 to 4. 11. A method of disinfecting tissue comprising: applying directly to tissue an antiseptic composition at use concentration,wherein the use concentration of the composition comprises: antimicrobial agent selected from the group consisting of I2, an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least 0.25 wt.-% to about 1.0 wt.-%;a hydroxycarboxylic acid in an amount of greater than 5 wt.-% up to about 25 wt.-%; andwater;a substantive film-forming polymer;wherein the hydroxycarboxylic acid is selected from the group consisting of lactic acid, malic acid, citric acid, 2-hydroxybutanoic acid, 3-hydroxybutanoic acid, mandelic acid, gluconic acid, tartaric acid, salicylic acid, and derivatives thereof, andallowing the antiseptic composition to remain on the tissue. 12. A method of making an antiseptic composition at use concentration, the method comprising combining components comprising: an antimicrobial agent selected from the group consisting of I2, an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least 0.25 wt-%;a hydroxycarboxylic acid in an amount in excess of 5 wt-%;water; anda substantive film-forming polymer. 13. The method of claim 12 wherein the hydroxycarboxylic acid and antimicrobial agent are combined and then the substantive film-forming polymer is added. 14. A method of disinfecting skin of a subject comprising: prior to an invasive procedure applying directly to the skin of the subject an antiseptic composition at use concentration, wherein the use concentration of the composition comprises: an antimicrobial agent selected from the group consisting of I2, an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least 0.25 wt-%;a hydroxycarboxylic acid in an amount of greater than 5 wt-%;an anionic or amphoteric surfactant; andwater; andallowing the antiseptic composition to remain on the skin during the invasive procedure;wherein the composition has a pH of 3 to 4. 15. The method of claim 14 wherein the invasive procedure is a surgical, catheterization, or needle puncture procedure. 16. The method of claim 14 wherein the hydroxycarboxylic acid is present in an amount of at least 6 wt-%. 17. The method of claim 14 wherein the antiseptic composition further includes a substantive film-forming polymer. 18. The method of claim 14 wherein the surfactant is a quaternary amine containing zwitterionic surfactant. 19. The method of claim 14 wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least 0.25 wt-% and not more than about 1.5 wt-%. 20. A method of disinfecting mucosal tissue of a subject comprising: applying directly to the mucosal tissue of the subject an antiseptic composition at use concentration, wherein the use concentration of the composition comprises: an antimicrobial agent selected from the group consisting of I2, an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least 0.25 wt-%;a hydroxycarboxylic acid in an amount of at least 5 wt-%;an anionic or amphoteric surfactant; andwater; andallowing the antiseptic composition to remain on the mucosal tissue. 21. The method of claim 20 wherein the mucosal tissue is nasal tissue. 22. The method of claim 20 wherein the antiseptic composition further includes a substantive film-forming polymer. 23. The method of claim 20 wherein the hydroxycarboxylic acid is present in an amount in excess of 5 wt-%. 24. The method of claim 20 wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least 0.25 wt-% and not more than about 1.5 wt-%. 25. The method of claim 20 wherein the antiseptic composition has a pH of 3 to 4. 26. The method of claim 20 wherein the surfactant is a quaternary amine containing zwitterionic surfactant. 27. The method of claim 20 wherein the antiseptic composition further includes a nonionic surfactant. 28. The method of claim 20 wherein the antiseptic composition further includes a polysaccharide. 29. An antiseptic composition at use concentration comprising: an antimicrobial agent selected from the group consisting of I2, an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least 0.25 wt-% and no more than about 1.5 wt-%;a hydroxycarboxylic acid in an amount in excess of 5 wt-%;an anionic or amphoteric surfactant; andwater;wherein the composition is stable; andwherein the composition has a pH of 3 to 4. 30. The antiseptic composition of claim 29 further comprising a film-forming polymer. 31. The antiseptic composition claim 30 wherein the film-forming polymer is substantive. 32. The antiseptic composition of claim 31 wherein a dry film of the composition is stable and substantive. 33. The antiseptic composition of claim 32 wherein the composition demonstrates one or more of the following characteristics: reduces normal skin flora by at least about 1 log in 2 minutes on a dry human skin site using ASTM testing method E1173-93 and a 30-second scrub with gauze soaked in the composition using moderate pressure;is substantially nontacky when in the form of a dry film;demonstrates a Draize score of zero in no greater than about 96 hours according to the Rabbit Eye Irritation Test; oradheres to a PSA-coated tape at a level of at least about 50% of the level of adhesion of the PSA-coated tape applied over dried BETADINE surgical scrub and paint solutions when measured using a 180 degree peel test after applying the PSA-coated tape to a dry film on dry human skin by rolling with a 2.1-kg, 5.1-cm wide roller, waiting at least 1 minute, and removing the PSA-coated tape at a peel angle of 180 degrees at a speed of 30.5 cm/minute. 34. The antiseptic composition of claim 29 wherein the surfactant is a quaternary amine containing zwitterionic surfactant. 35. The antiseptic composition of claim 29 further comprising a nonionic surfactant. 36. The antiseptic composition of claim 29 further comprising a polysaccharide. 37. The antiseptic composition of claim 29 further comprising a cationic film-forming polymer. 38. An antiseptic composition at use concentration comprising: an iodophor in an amount of greater than 5 wt-%, wherein the iodophor comprises a carrier selected from the group consisting of a polyvinylpyrrolidone, a copolymer of N-vinyl lactam, a polyether glycol, a polyvinyl alcohol, a polyacrylamide, a polysaccharide, and combinations thereof;a hydroxycarboxylic acid in an amount in excess of 5 wt-%;an anionic or amphoteric surfactant; andwater;wherein the composition is stable; andwherein the composition has a pH of 3 to 4. 39. The antiseptic composition of claim 38 further comprising a film-forming polymer. 40. The antiseptic composition of claim 38 wherein the surfactant is a quaternary amine containing zwitterionic surfactant. 41. The antiseptic composition of claim 38 further comprising a nonionic surfactant. 42. An antiseptic composition at use concentration comprising: antimicrobial agent selected from the group consisting of I2, an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least 0.25 wt.-% to about 1.0 wt.-%;a hydroxycarboxylic acid in an amount of greater than 5 wt.-% to about 25 wt.-%;an anionic or amphoteric surfactant;and water;wherein the hydroxycarboxylic acid is selected from the group consisting of lactic acid, malic acid, citric acid, 2-hydroxybutanoic acid, 3-hydroxybutanoic acid, mandelic acid, gluconic acid, tartaric acid, salicylic acid, and derivatives thereof,wherein the composition has a pH of 3 to 4. 43. The antiseptic composition of claim 42 further comprising a film-forming polymer. 44. The antiseptic composition of claim 42 wherein the surfactant is a quaternary amine containing zwitterionic surfactant. 45. The antiseptic composition of claim 42 further comprising a nonionic surfactant. 46. An antiseptic composition at use concentration comprising: an antimicrobial agent selected from the group consisting of I2, an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least 0.25 wt-% and not more than about 1.5 wt-%;a hydroxycarboxylic acid in an amount in excess of 5 wt-%;water; andan anionic or amphoteric surfactant;wherein the composition has a pH of 3 to 4. 47. The antiseptic composition of claim 46 further comprising a substantive film-forming polymer. 48. The antiseptic composition of claim 47 wherein the antimicrobial agent is an iodophor present in an amount sufficient to provide an available iodine concentration of at least 0.25 wt-% and not more than about 1.5 wt-%. 49. A method of disinfecting nasal mucosal tissue comprising: applying directly to nasal mucosal tissue an antiseptic composition at use concentration, wherein the use concentration of the composition comprises: an antimicrobial agent selected from the group consisting of I2, an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least 0.25 wt-%;a hydroxycarboxylic acid in an amount in excess of 5 wt-%; andwater; andallowing the antiseptic composition to remain on the tissue. 50. A method of disinfecting tissue comprising: applying directly to tissue an antiseptic composition at use concentration, wherein the use concentration of the composition comprises: an antimicrobial agent selected from the group consisting of I2, an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least 0.25 wt-%;a hydroxycarboxylic acid in an amount in excess of 5 wt-%;an anionic or amphoteric surfactant; andwater; andallowing the antiseptic composition to remain on the tissue.
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