최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0776176 (2013-02-25) |
등록번호 | US-8852100 (2014-10-07) |
발명자 / 주소 |
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출원인 / 주소 |
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인용정보 | 피인용 횟수 : 2 인용 특허 : 318 |
A method, comprising receiving at least one of a signal relating to a first cardiac activity and a signal relating to a first body movement from a patient; triggering at least one of a test of the patient's responsiveness, awareness, a second cardiac activity, a second body movement, a spectral anal
A method, comprising receiving at least one of a signal relating to a first cardiac activity and a signal relating to a first body movement from a patient; triggering at least one of a test of the patient's responsiveness, awareness, a second cardiac activity, a second body movement, a spectral analysis test of the second cardiac activity, and a spectral analysis test of the second body movement, based on at least one of the signal relating to the first cardiac activity and the signal relating to the first body movement; determining an occurrence of an epileptic event based at least in part on said one or more triggered tests; and performing a further action in response to said determination of said occurrence of said epileptic event. Further methods allow classification of epileptic events. Apparatus and systems capable of implementing the method.
1. A method, comprising: receiving a signal relating to a cardiac activity from a patient;deriving at least one cardiac index from the cardiac signal, wherein said at least one cardiac index is selected from a heart rate index and an EKG morphology index;receiving a signal relating to a body movemen
1. A method, comprising: receiving a signal relating to a cardiac activity from a patient;deriving at least one cardiac index from the cardiac signal, wherein said at least one cardiac index is selected from a heart rate index and an EKG morphology index;receiving a signal relating to a body movement from the patient;deriving at least one body movement index from the body movement signal, wherein said at least one body movement index is selected from a body posture, a body position, a fall, and a body movement derived from an accelerometer;detecting a possible epileptic seizure based on at least one of the at least one cardiac index and the at last one body movement index;triggering a test of the patient's responsiveness based on said detecting;performing one of (a) confirming the detecting of the possible epileptic seizure; or(b) overruling the detecting of the possible epileptic seizure,wherein said confirming or overruling is based upon the result of the responsiveness test; andperforming a further action in response to said confirming the detecting of the possible epileptic seizure. 2. The method of claim 1, wherein the further action comprises one or more of: logging the occurrence of at least one of said detecting and said confirming the detecting of the possible epileptic seizure;logging the time of occurrence of at least one of said detecting and said confirming the detecting of the possible epileptic seizure;providing at least one of a warning, alarm or alert to the patient, a caregiver or a health care provider;providing a therapy to prevent, abort, and/or reduce the severity of the epileptic seizure;logging the patient's response to said test of the patient's responsiveness;assessing the severity of the epileptic seizure;identifying the end of the epileptic seizure;assessing the patient's degree of post-ictal impairment; anddetermining a time required for the patient to return to an interictal reference responsiveness level. 3. The method of claim 1, wherein confirming the detecting of the possible epileptic seizure is based on a finding that the patient's responsiveness differs from an interictal reference responsiveness level. 4. The method of claim 1 wherein said test of the patient's responsiveness is selected from one of: a test requiring a simple motor response;a test requiring a simple verbal responsea test requiring a complex motor response;a test requiring a complex verbal response;a test involving a noxious sensory stimulus;a test involving an acoustic sensory stimulus;a test involving a non-noxious sensory stimulus;a complex reaction time test; anda test comprising questions assessing at least one of knowledge, judgment, abstraction and memory. 5. The method of claim 1, wherein detecting a possible epileptic seizure is based at least in part on a determination of a correlation between the at least one cardiac index and at least one body movement index. 6. The method of claim 1, further comprising classifying said epileptic seizure based upon at least one of said at least one cardiac index;said at least one body movement index, andsaid result of said responsiveness test. 7. The method of claim 6, wherein said epileptic seizure is classified as a generalized tonic-clonic seizure when the following occur in a patient in a first, non-recumbent position: a) said body movement comprises a fall from said first, non-recumbent position, wherein (i) said fall is associated with a loss of responsiveness, a loss of awareness, or both; and (ii) said fall is followed by generalized epileptic body movements. 8. A method, comprising: receiving a signal relating to a body movement from the patient;determining from said body movement signal that the patient is in a first, non-recumbent position;detecting an epileptic seizure by determining from said body movement signal that the patient has had a fall from said first, non-recumbent position to a second position;triggering a test of the patient's responsiveness based at least on part said determining that the patient has had a fall;performing one of (a) confirming the detecting of the epileptic seizure; or(b) overruling the detecting of the epileptic seizure,wherein said confirming or overruling is based upon the result of the responsiveness test. 9. The method of claim 8 further comprising classifying said seizure as a generalized tonic-clonic seizure when (a) the result of said responsiveness test indicates that the patient has had a loss of responsiveness, and(b) the fall to said second position is followed by generalized epileptic body movements. 10. The method of claim 8 further comprising classifying said seizure as a tonic seizure when (a) the body movement signal indicates an increase in muscle tone above a reference value and an absence of generalized body movements; and(b) the result of the responsiveness test indicates that the patient has had a loss of responsiveness. 11. A method of detecting an epileptic seizure, comprising: receiving at least two body signals selected from a body movement signal, a cardiac activity signal, and a responsiveness signal;determining at least one feature from each of said at least two body signals, wherein(a) the feature determined from the cardiac signal is an increase in the patient's heart rate above an interictal reference value;(b) the feature determined from the first body movement signal is selected from (i) an increase in axial or limb muscle tone substantially above an interictal or exercise value for the patient;(ii) a decrease in axial muscle tone when the patient is in a non-recumbent position;(iii) a fall followed by an increase in body muscle tone; or(iv) a fall followed by generalized epileptic body movements; and(c) the feature determined from the responsiveness signal is (i) a decrease in the patient's responsiveness below an interictal reference value;(ii) a decrease in the patient's awareness below an interictal reference value; andperforming a further action in response to said confirming the detecting of the possible epileptic seizure. 12. The method of claim 11, further comprising classifying said epileptic seizure (a) as a complex partial seizure based upon a finding the patient's change in cardiac activity is associated with impaired awareness and is not associated with (i) a fall, (ii) generalized increase in muscle tone, or (iii) generalized body movements; and(b) as a simple partial seizure based upon a finding the patient's change in cardiac activity is not associated with impaired awareness. 13. The method of claim 11 wherein performing a further action comprises logging one or more of a time of onset of the epileptic seizure, a time of termination of the epileptic seizure, a severity of the epileptic seizure, an impact of the epileptic seizure on the patient, an interval between the epileptic seizure and at least one preceding epileptic seizure, an epileptic seizure frequency over a time window, an epileptic seizure burden over a time window, time spent in epileptic seizures over a time window, or a type of epileptic seizure. 14. A system for detecting an epileptic seizure, comprising: an autonomic signal module for receiving a cardiac signal and determining at least one cardiac feature selected from an increase in the patient's heart rate above an interictal value and a heart beat morphology feature;a neurological signal module for receiving at least one of a kinetic signal and a cognitive signal and determining at least one of a kinetic feature from the kinetic signal and a cognitive feature from the cognitive signal, wherein said kinetic feature is selected from (a) an increase in axial or limb muscle tone substantially above an interictal or exercise value for the patient, (b) a decrease in axial muscle tone when the patient is in a non-recumbent position, (c) a fall followed by an increase in body muscle tone, or (d) a fall followed by generalized epileptic body movements; andsaid cognitive feature is selected from (a) a decrease in the patient's responsiveness below an interictal reference value, (b) a decrease in the patient's awareness below an interictal reference value, (c) a memory feature, (d) an attention feature, and (e) a language feature; anda detection module for (a) detecting an epileptic seizure based on at least two of a cardiac feature, a kinetic feature, an awareness feature, and a responsiveness feature, and (b) performing a further action in response to said detecting. 15. The system of claim 14, wherein said cardiac signal is at least one of an electrocardiogram (EKG) signal, a phonocardiogram (PKG) signal, an apexcardiography signal, a blood pressure signal, and an echocardiogram signal. 16. The system of claim 14, wherein said kinetic signal is at least one of an accelerometer signal, an inclinometer signal, an actigraph signal, an imaging signal, a dynamometer signal, a gyroscope signal, and an electromyogram (EMG) signal.
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