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The invention is generally directed to devices and methods for sealing a puncture or an opening through a wall of a blood vessel or a body cavity. The device includes a structural member and a sealing material associated with the structural member. The structural member includes a rod, a first obstr

The invention is generally directed to devices and methods for sealing a puncture or an opening through a wall of a blood vessel or a body cavity. The device includes a structural member and a sealing material associated with the structural member. The structural member includes a rod, a first obstructing body and a second obstructing body. The first obstructing body is affixed against an inner surface of the wall of the blood vessel or body cavity and the second obstructing body is affixed against an outer surface of the wall of the blood vessel or body cavity once placed at the puncture or the opening. The sealing material includes a reconstituted or naturally-derived collagenous material, which can expand at the puncture or the opening to restore hemostasis and enhance sealing.

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1. A medical device for immediate sealing of a puncture or an opening through a wall of a blood vessel or a body cavity, comprising: a) a structural member which can be in a first collapsed configuration and in a second expanded configuration, the structural member comprising i) an elongated member

1. A medical device for immediate sealing of a puncture or an opening through a wall of a blood vessel or a body cavity, comprising: a) a structural member which can be in a first collapsed configuration and in a second expanded configuration, the structural member comprising i) an elongated member having a distal end and a proximal end, wherein at least a portion of the elongated member comprises protruding structural elements;ii) a first obstructing body disposed on the distal end of the elongated member and having a first obstructing body perimeter enclosing a substantially solid surface; andiii) a second obstructing body having a second obstructing body perimeter enclosing a substantially solid surface capable of being translated along the portion of the elongated member comprising the protruding structural elements for adjusting a distance between the first and the second obstructing bodies; andb) a remodelable sealing material associated with the structural member comprising a reconstituted or naturally-derived collagenous material wherein the collagenous material encourages and promotes tissue ingrowth at the puncture or the opening, wherein the sealing material is attached to or lining at least a portion of at least one of the elongated member, the first obstructing body and the second obstructing body, wherein the sealing material is substantially enclosed within the structural member once the structural member is in the expanded configuration and deployed at the puncture or the opening;wherein the first and the second obstructing bodies are opposing each other once the structural member is in the expanded configuration,wherein the first obstructing body is configured to be affixed against an inner surface of the wall of the blood vessel or body cavity so that at least the first obstructing body perimeter is in a continuous contact with the inner surface of the wall of the blood vessel or body cavity and the second obstructing body is configured to be affixed against an outer surface of the wall of the blood vessel or body cavity so that at least the second obstructing body perimeter is in a continuous contact with the outer surface of the wall of the blood vessel or body cavity, once the structural member is in the expanded configuration and deployed at the puncture or the opening to immediately seal the puncture or the opening and substantially prevent leakage through the puncture or the opening, andwherein the first and the second obstructing bodies are configured to biodegrade or detach following the tissue ingrowth and the closure of the puncture or opening. 2. The device of claim 1, wherein the first obstructing body is selected from the group consisting of a plug, an expandable and collapsible basket, a disc; and the second obstructing body is selected from the group consisting of a plug, an expandable and collapsible basket, a disc. 3. The device of claim 1, wherein the first obstructing body is a plug, and the second obstructing body is a plug. 4. The device of claim 1, wherein the first obstructing body is a disc, and the second obstructing body is a disc. 5. The device of claim 1, wherein the first obstructing body is an expandable and collapsible basket and the second obstructing body is an expandable and collapsible basket. 6. The device of claim 1, further comprising a delivery member. 7. The device of claim 6, wherein the delivery member is a catheter. 8. The device of claim 1, wherein the reconstituted or naturally-derived collagenous material comprises an extracellular matrix (ECM) material. 9. The device of claim 8, wherein the ECM material is a submucosa. 10. The device of claim 8, wherein the ECM material is in a form of foam. 11. The device of claim 8, wherein the extracellular matrix (ECM) material comprises bioactive components native to a source tissue. 12. The device of claim 11, wherein the bioactive components comprise one or more growth factors. 13. The device of claim 12, wherein the growth factors are selected from the group consisting of basic fibroblast growth factor (FGF-2), transforming growth factor beta (TGF-beta), epidermal growth factor (EGF), and platelet derived growth factor (PDGF). 14. The device of claim 8, further comprising at least one of heparin, heparin sulfate, hyaluronic acid, and fibronectin. 15. The device of claim 1, wherein the reconstituted or naturally-derived collagenous material is in a fluidized form. 16. The device of claim 1, wherein the reconstituted or naturally-derived collagenous material is wrapped around the elongated member. 17. The device of claim 1, wherein the reconstituted or naturally-derived collagenous material is associated with the first obstructing body and the second obstructing body. 18. The device of claim 1, wherein the puncture or the opening is a vascular puncture made during a vascular, endoscopic, or orthopedic surgical procedures. 19. The device of claim 18, wherein the puncture or the opening is in a septum. 20. The device of claim 1, wherein the sealing material is associated with at least a portion or at least one element of the structural member by at least one of: i) lining an inner side of the first obstructing body;ii) lining an inner side of the second obstructing body; and/oriii) wrapping around the elongated member. 21. The device of claim 1, wherein the elongated member is one of a rod, a tube, a string, a thread, or a series of wires. 22. The device of claim 1, wherein the protruding structural elements are beads, tie-wrap-like elements, oriented fibers, or a combination thereof. 23. A method of using a medical device having (i) a structural member comprising an elongated member having a distal end and a proximal end, wherein at least a portion of the elongated member comprises protruding structural elements, a first obstructing body disposed on the distal end of the elongated member and having a first obstructing body perimeter enclosing a substantially solid surface; and a second obstructing body having a second obstructing body perimeter enclosing a substantially solid surface capable of being translated along the portion of the elongated member comprising the protruding structural elements for adjusting a distance between the first and the second obstructing bodies, wherein the first and the second obstructing bodies are configured to biodegrade or detach following the tissue ingrowth and the closure of the puncture or opening; and (ii) a remodelable sealing material associated with the structural member comprising reconstituted or naturally derived collagenous material for sealing a puncture or an opening through a wall of a blood vessel or a body cavity, wherein the sealing material is attached to or lining at least a portion of at least one of the elongated member, the first obstructing body and the second obstructing body, comprising the steps of deploying though a delivery member at the site of the puncture or opening the distal end of the elongated member on a luminal side of the blood vessel or body cavity so that the first obstructing body engages the inner surface of the wall of the blood vessel or body cavity at the puncture or the opening and at least the first obstructing body perimeter is in a continuous contact with the inner surface of the wall of the blood vessel or body cavity;deploying though a delivery member at site of puncture or the opening the proximal end of the elongated member on an outer side of the blood vessel or body cavity so that the second obstructing body is positioned on an outer surface of the wall of the blood vessel or body cavity at the puncture or the opening and at least the second obstructing body perimeter is in a continuous contact with the outer surface of the wall of the blood vessel or body cavity,wherein at least one of the first obstructing body and the second obstructing body radially expand so that the structural member assumes an expanded configuration following the deployment at the puncture or the opening to immediately seal the puncture or the opening and prevent leakage through the puncture or the opening,wherein the sealing material is substantially enclosed within the structural member once the structural member is in an expanded configuration and deployed at the site of the puncture or the opening andwherein the collagenous material encourages and promotes tissue ingrowth at the puncture or the opening. 24. The method of claim 23, wherein the puncture or the opening is a vascular puncture made during a vascular, endoscopic, or orthopedic surgical procedure. 25. The method of claim 23, wherein the puncture or the opening is in a septum. 26. The method of claim 23, wherein the second obstructing body is disposed on the proximal end of the elongated member after the proximal end of the elongated member is deployed. 27. A bodily opening closure system for immediate sealing of the bodily opening comprising: a) a structural member which can be in a first collapsed configuration and in a second expanded configuration, the structural member comprising: ii) a first obstructing body having a first obstructing body perimeter enclosing a substantially solid surface, the first obstructing body adapted to contact the interior of the bodily opening;ii) an elongated member fixed to the first obstructing body; andiii) a second obstructing body having a second obstructing body perimeter enclosing a substantially solid surface and disposed on the elongated member and capable of being translated along the elongated member;wherein the first obstructing body in the expanded configuration of the structural member has a diameter that is greater than the diameter of the elongated member,wherein at least a portion of the elongated member comprises protruding structural elements for adjusting a distance between the first and the second obstructing bodies, wherein the structural elements resist the travel back of the second obstructing body along the elongated member, andb) a remodelable sealing material associated with the structural member comprising a reconstituted or naturally-derived collagenous material wherein the collagenous material encourages and promotes tissue ingrowth, wherein the sealing material is attached to or lining at least a portion of at least one of the elongated member, the first obstructing body and the second obstructing body, wherein the sealing material is substantially enclosed within the structural member once the structural member is in an expanded configuration and deployed at the puncture or the opening;wherein the first and the second obstructing bodies are opposing each other once the structural member is in the expanded configuration,wherein the first obstructing body is configured to be affixed against an inner surface of the wall of the bodily opening so that at least the first obstructing body perimeter is in a continuous contact with the inner surface of the wall of the bodily opening and the second obstructing body is configured to be affixed against an outer surface of the wall of the bodily opening so that at least the second obstructing body perimeter is in a continuous contact with the outer surface of the wall of the bodily opening once the structural member is placed at the bodily opening to immediately seal the bodily opening and prevent leakage through the opening; andwherein the first and the second obstructing bodies are configured to biodegrade or detach following the tissue ingrowth in the bodily opening. 28. The system of claim 27, wherein the reconstituted or naturally-derived collagenous material comprises an extracellular matrix (ECM) material. 29. The system of claim 28, wherein the ECM material is a submucosa. 30. The system of claim 28, wherein the ECM material is in a form of foam. 31. The system of claim 28, wherein the reconstituted or naturally-derived collagenous material comprises a folded or rolled sheet of ECM, with a central passage allowing the ECM to travel along the elongated member. 32. The system of claim 27, further comprising a delivery member having a body portion with a distal end, a proximal end, and a lumen extending between and through said ends, wherein the structural member in the collapsed configuration and the sealing material are disposed in the lumen of the delivery member. 33. The system of claim 27, wherein the protruding structural elements are beads, tie-wrap-like elements, oriented fibers, or a combination thereof. 34. The system of claim 27, wherein the first obstructing body has a convex exterior surface and an opposite open concave interior surface. 35. The system of claim 27, wherein the first obstructing body has a domed shape. 36. The system of claim 27, wherein the tissue ingrowth is at the bodily opening to close the opening. 37. The system of claim 27, wherein the first obstructing body has a cap shape. 38. The system of claim 37, wherein the second obstructing body has a disc shape. 39. A closure system for immediate sealing of a bodily opening, the device comprising: i) a first obstructing body having a first obstructing body perimeter enclosing a substantially solid surface, the first obstructing body in an expanded configuration of the device having a convex exterior surface, an opposite open concave interior surface, said first obstructing body adapted to contact the interior of the bodily opening and at least the first obstructing body perimeter is in a continuous contact with the interior surface of the wall of the bodily opening;ii) an elongated member fixed to the first obstructing body, wherein at least a portion of the elongated member comprises protruding structural elements; andiii) a remodelable sealing material attached to or lining at least a portion of at least one of the elongated member and the first obstructing body, the remodelable sealing material comprising a reconstituted or naturally-derived collagenous material, wherein the sealing material is substantially enclosed within the structural member once the structural member is in an expanded configuration and deployed at the bodily opening, and wherein the collagenous material encourages and promotes tissue ingrowth. 40. The device of claim 39, further comprising at least one disc associated with the elongated member, wherein the disc is capable of being translated along the elongated member. 41. The device of claim 40, wherein the protruding structural elements prevent the at least one disc from retracting backwards. 42. The device of claim 39, wherein the protruding structural elements are beads, tie-wrap-like elements, oriented fibers, or a combination thereof.