A fenestration piercing the otic capsule bone of the cochlea receives a therapeutic appliance, such as a microactuator, plug, micropump for drug or therapeutic agent delivery, electrode, and the like. Several different ways of achieving a ‘water tight’ seal between the otic capsule bone and the ther
A fenestration piercing the otic capsule bone of the cochlea receives a therapeutic appliance, such as a microactuator, plug, micropump for drug or therapeutic agent delivery, electrode, and the like. Several different ways of achieving a ‘water tight’ seal between the otic capsule bone and the therapeutic appliance are provided. The therapeutic appliance may be implanted with or without a sheath or sleeve lining the wall of the fenestration formed using specialized surgical burrs. The burrs permit safely fenestrating the otic capsule bone adjacent to the scala tympani of the cochlea without damaging the basilar membrane or organ of corti. This approach may also be adopted for safely fenestrating other areas of the inner ear such as the scala vestibuli, bony labyrinth of semicircular canals, or walls of the vestibule, or the oval or round windows thereof.
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1. A therapeutic appliance configured for insertion into a cylindrically-shaped fenestration that pierces a wall of a cochlea of a subject, the therapeutic appliance comprising: a cylindrically shaped outer barrel having an outer cylindrical surface configured to be disposed at a distal end of the w
1. A therapeutic appliance configured for insertion into a cylindrically-shaped fenestration that pierces a wall of a cochlea of a subject, the therapeutic appliance comprising: a cylindrically shaped outer barrel having an outer cylindrical surface configured to be disposed at a distal end of the wall of the cochlea and configured to be inserted into and firmly fixed in a corresponding outer portion of the cylindrically-shaped fenestration, the outer barrel having an outer diameter dimension along a longitudinal axis, the outer surface of the outer barrel configured to be in contact with the distal end of the fenestration in the wall of the cochlea; anda cylindrically shaped inner barrel having an outer cylindrical surface configured to be disposed at a proximal end of the wall of the cochlea closest to the scala tympani region of the cochlea and opposite to the distal end, the inner barrel coupled to the outer barrel and extending away from the outer barrel along the longitudinal axis toward the proximal end, the inner barrel having an inner barrel diameter dimension about the longitudinal axis, wherein the inner barrel diameter dimension is smaller than the outer barrel diameter dimension, the inner barrel configured to be inserted into and to be firmly fixed in a corresponding inner portion of the fenestration adjacent to the outer portion of the fenestration, the outer surface of the inner barrel configured to be in contact with the proximal end of the fenestration in the wall of the cochlea, wherein a sleeve is positioned between the fenestration and the therapeutic appliance such that the inner barrel is in contact with a first circular area of the sleeve having a first sleeve diameter dimension corresponding to the inner barrel diameter dimension and the outer barrel is in contact with a second circular area of the sleeve having a second sleeve diameter dimension corresponding with the outer barrel diameter dimension. 2. The therapeutic appliance of claim 1, further comprising: an annularly-shaped shelf positioned between the inner barrel and the outer barrel, the shelf having a shelf diameter dimension less than the outer barrel diameter dimension and greater than the inner barrel diameter dimension. 3. The therapeutic appliance of claim 1, further comprising: a biocompatible elastomeric coating disposed on an outer surface of the therapeutic appliance, the coating for effecting a seal between the outer surface of the therapeutic appliance and the sleeve. 4. The therapeutic appliance of claim 1, further comprising: an expandable bladder configured to be interposed between the therapeutic appliance and the sleeve for effecting a seal therebetween. 5. The therapeutic appliance of claim 1, wherein the outer barrel of the therapeutic appliance is encircled by at least one ring that is configured to mate with and engage a corresponding groove of the sleeve. 6. The therapeutic appliance of claim 1, wherein the inner barrel of the therapeutic appliance is encircled by at least one ring that is configured to mate with and engage a corresponding groove of the sleeve. 7. The therapeutic appliance of claim 2, further comprising: an O-ring disposed on an outer surface of the shelf of the therapeutic appliance for effecting a seal between the sleeve and the shelf. 8. A therapeutic appliance configured to be implanted into a correspondingly shaped fenestration in a wall of a cochlea, the therapeutic appliance comprising: a cylindrically shaped outer barrel having an outer cylindrical surface configured to be disposed distally from an inner section of the cochlea, the outer barrel having an outer barrel diameter dimension along a longitudinal axis, the outer surface of the outer barrel configured to be in contact with the distal end of the fenestration in the wall of the cochlea; anda cylindrically shaped inner barrel having an outer cylindrical surface configured to be disposed proximally to the inner section of the cochlea in communication with the scala tympani region of the cochlea, the inner barrel aligned coaxial with and adjacent to the outer barrel along the longitudinal axis such that the inner barrel extends away from the outer barrel, the inner barrel having an inner barrel diameter dimension about the longitudinal axis, wherein the inner barrel diameter dimension is smaller than the outer barrel diameter dimension, the outer surface of the inner barrel configured to be in contact with the proximal end of the fenestration in the wall of the cochlea and further comprising:a shelf positioned between the inner and outer barrels having a length dimension along the longitudinal axis, the shelf having a shelf diameter dimension, wherein the shelf diameter dimension is smaller than the outer barrel diameter dimension and larger than the inner barrel diameter dimension.
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