Methods and systems of treating pancreatitis pain caused by sphincter of Oddi dysfunction
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-001/36
A61N-001/372
출원번호
US-0358002
(2009-01-22)
등록번호
US-8914112
(2014-12-16)
발명자
/ 주소
Whitehurst, Todd K.
Carbunaru, Rafael
Jaax, Kristen N.
DiGiore, Andrew
Schleicher, Brett
Baldwin, Greg
Hastings, Roger
출원인 / 주소
Boston Scienctific Neuromodulation Corporation
대리인 / 주소
Vista IP Law Group LLP
인용정보
피인용 횟수 :
0인용 특허 :
28
초록▼
Methods and systems of treating a patient with pancreatitis pain include providing a stimulator, configuring one or more stimulation parameters to control sphincter of Oddi function, programming the stimulator with the one or more stimulation parameters, generating a stimulus configured to control s
Methods and systems of treating a patient with pancreatitis pain include providing a stimulator, configuring one or more stimulation parameters to control sphincter of Oddi function, programming the stimulator with the one or more stimulation parameters, generating a stimulus configured to control sphincter of Oddi function with the stimulator in accordance with the one or more stimulation parameters, and applying the stimulus with the stimulator to one or more stimulation sites in accordance with the one or more stimulation parameters.
대표청구항▼
1. A method of treating a patient with pancreatitis pain, comprising: generating a first stimulus and a second stimulus with a stimulator implanted within the patient; andapplying the first stimulus and the second stimulus to a stimulation site comprising at least one or more of a region of the sphi
1. A method of treating a patient with pancreatitis pain, comprising: generating a first stimulus and a second stimulus with a stimulator implanted within the patient; andapplying the first stimulus and the second stimulus to a stimulation site comprising at least one or more of a region of the sphincter of Oddi and a nerve innervating a sphincter of Oddi of the patient, such that the first applied stimulus contracts the sphincter of the Oddi during a first period and the second applied stimulus relaxes the sphincter of the Oddi during a second period to treat the pancreatitis pain. 2. The method of claim 1, wherein the stimulation site comprises at least one or more of a sphincter of Oddi muscle tissue, a nerve innervating the sphincter of Oddi muscle tissue, a pre-ganglionic cholinergic nerve, an efferent nerve, a tissue of the duodenum near the sphincter of Oddi, and a pancreatic duct. 3. The method of claim 1, wherein the first stimulus and the second stimulus performs at least one of a blocking and an invoking of one or more myoelectrical potentials at the stimulation site. 4. The method of claim 1, wherein the stimulator is coupled to one or more electrodes, and wherein at least one of the first stimulus and the second stimulus comprises a stimulation current delivered via the electrodes. 5. The method of claim 1, wherein at least one of the first stimulus and the second stimulus comprises an infusion of one or more drugs at the stimulation site. 6. The method of claim 1, further comprising: configuring one or more stimulation parameters designed to control the function of the sphincter of Oddi; andprogramming the stimulator with the one or more stimulation parameters. 7. The method of claim 6, further comprising sensing at least one indicator related to the pancreatitis pain and using the at least one sensed indicator to adjust one or more of the stimulation parameters. 8. The method of claim 7, wherein the indicator comprises at least one or more of a contraction of one or more muscles of the sphincter of Oddi, a relaxation of one or more muscles of the sphincter of Oddi, a need for pancreatic secretion, a neurotransmitter level, a patient input, a change in hormone concentration, a detected stomach activity, a circumference change in a duodenum, a pyloric sphincter contraction, a detection of food passing through the gastrointestinal tract, a change in pH, an audible sound, a contraction of exocrine tissue, a pressure change in a bile duct, a change in myoelectrical potentials, a pressure change in a pancreatic duct, a pressure change in an ampulla, a pressure change in the duodenum, a circumference change in the pancreatic duct, a circumference change in the ampulla, and a circumference change in the duodenum. 9. The method of claim 7, further comprising sensing the at least one indicator with at least one or more of a patient feedback sensor, a hormonal sensor, a chemical sensor, a piezoelectric sensor, a strain gauge, an optical sensor, a pH sensor, an auditory sensor, and a pressure sensor. 10. The method of claim 1, further comprising implanting the stimulator within the patient. 11. The method of claim 1, wherein the first period is when gastrointestinal activity is relatively low, and wherein the second period is when gastrointestinal activity is relatively high. 12. The method of claim 1, wherein the first stimulus is applied to the stimulation site between meals, and wherein the second stimulus is applied to the stimulation site during meals. 13. The method of claim 1, wherein the stimulation site comprises the sphincter of Oddi of the patient. 14. The method of claim 1, wherein the stimulation site comprises the nerve innervating the sphincter of Oddi of the patient.
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