초록 ▼

A resveratrol-containing composition capable of providing a therapeutic benefit to a subject such as modulation of a biological activity, improving cell transplantation therapy, or improving macular degeneration or dystrophy treatments. The compositions comprise trans-resveratrol, a metal chelator,

A resveratrol-containing composition capable of providing a therapeutic benefit to a subject such as modulation of a biological activity, improving cell transplantation therapy, or improving macular degeneration or dystrophy treatments. The compositions comprise trans-resveratrol, a metal chelator, one or more additional antioxidants such as quercetin, gamma-tocotrienol, or apple polyphenols, allicin, and nucleotides.

대표청구항 ▼

1. A method of administering a supplement, comprising: administering to a human subject a composition comprising trans-resveratrol in an amount of about 0.2 to about 2 mg per kg of body weight of the subject,a metal chelating agent in an amount of about 0.5 to about 3 mg per kg of body weight of the

1. A method of administering a supplement, comprising: administering to a human subject a composition comprising trans-resveratrol in an amount of about 0.2 to about 2 mg per kg of body weight of the subject,a metal chelating agent in an amount of about 0.5 to about 3 mg per kg of body weight of the subject,one or more nucleotides in an amount of about 0.5 to about 2 mg per kg of body weight of the subject, andone or more additional phenolic antioxidants in a total amount of about 0.05 to about 2 mg per kg of body weight of the subject,wherein said administration is effective to modulate a biological activity in the human subject as compared to administration of resveratrol alone. 2. The method of claim 1, wherein the metal chelating agent comprises phytic acid. 3. The method of claim 1, wherein the one or more additional phenolic antioxidants are selected from the group consisting of apigenin, caffeic acid, epigallocatechin 3-gallate (EGCG), ferulic acid, and quercetin. 4. The method of claim 1, wherein the one or more additional phenolic antioxidants comprises a tocotrienol. 5. The method of claim 4, wherein the tocotrienol is gamma-tocotrienol. 6. The method of claim 1, wherein the one or more additional phenolic antioxidants comprise apple polyphenols. 7. The method of claim 1, wherein the composition further comprises allicin in an amount of about 0.5 to about 2 mg per kg of body weight of the subject. 8. A composition for oral administration to a human subject, comprising: trans-resveratrol in an amount of about 10 to about 100 mg;a metal chelating agent in an amount of about 25 to about 150 mg;one or more nucleotides in an amount of about 0.5 to about 2 mg; andadditional phenolic antioxidants in a total amount of about 2.5 to about 75 mg, wherein the additional phenolic antioxidants are selected from the group consisting of apigenin, caffeic acid, epigallocatechin 3-gallate (EGCG), ferulic acid, quercetin, gamma-tocotrienol, tocotrienol, and apple polyphenols. 9. The composition of claim 8, wherein the metal chelating agent comprises phytic acid. 10. The composition of claim 8, wherein the additional phenolic antioxidants comprise gamma-tocotrienol. 11. The composition of claim 8, wherein the additional phenolic antioxidants comprise apple polyphenols. 12. The composition of claim 8, further comprising allicin in an amount of about 25 to about 100 mg. 13. The composition of claim 8, wherein the additional phenolic antioxidants comprises tocotrienol. 14. The composition of claim 8, wherein the composition further comprises nucleotide precursors, nucleotide derivatives, ribonucleosides or deoxyribonucleosides. 15. A composition for oral administration to a human subject comprising: trans-resveratrol in an amount of about 0.2 to about 2 mg per kg of body weight of the subject,a metal chelating agent in an amount of about 0.5 to about 3 mg per kg of body weight of the subject,one or more nucleotides in an amount of about 0.5 to about 2 mg per kg of body weight of the subject, andone or more additional phenolic antioxidants in a total amount of about 0.05 to about 2 mg per kg of body weight of the subject,wherein said composition is effective to modulate a biological activity in the human subject as compared to administration of resveratrol alone. 16. The composition of claim 15, wherein the metal chelating agent comprises phytic acid. 17. The composition of claim 15, wherein the one or more additional phenolic antioxidants are selected from the group consisting of apigenin, caffeic acid, epigallocatechin 3-gallate (EGCG), ferulic acid, and quercetin. 18. The composition of claim 15, wherein the one or more additional phenolic antioxidants comprise apple polyphenols. 19. The composition of claim 15, wherein the composition further comprises allicin in an amount of about 0.5 to about 2 mg per kg of body weight of the subject.