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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0239719 (2008-09-26) |
등록번호 | US-8925545 (2015-01-06) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 634 |
A ventilation apparatus for treating sleep apnea is provided. A ventilator controlled by a control system may deliver ventilation gas through a ventilation gas delivery circuit to a ventilation catheter and a distal tip on the ventilation catheter. One or more sensors may detect a breathing cycle an
A ventilation apparatus for treating sleep apnea is provided. A ventilator controlled by a control system may deliver ventilation gas through a ventilation gas delivery circuit to a ventilation catheter and a distal tip on the ventilation catheter. One or more sensors may detect a breathing cycle and the control system may operate the ventilator in synchrony with the breathing cycle. The distal tip may deliver the ventilation gas superiorly from the transtracheal ventilation catheter towards an upper airway, inferiorly from the transtracheal ventilation catheter towards a lung, or a combination of both. The ventilation catheter may be a transtracheal catheter, a trans-oral catheter or a trans-nasal catheter.
1. A ventilation apparatus for treating sleep apnea, the apparatus comprising: a ventilator for delivering ventilation gas;a control system for the ventilator;a trans-tracheal ventilation catheter for insertion a trachea;a distal tip on the trans-tracheal ventilation catheter;one or more first senso
1. A ventilation apparatus for treating sleep apnea, the apparatus comprising: a ventilator for delivering ventilation gas;a control system for the ventilator;a trans-tracheal ventilation catheter for insertion a trachea;a distal tip on the trans-tracheal ventilation catheter;one or more first sensors, signals from the one or more first sensors measuring actual respiration;one or more second sensors, signals from the one or more second sensors measuring respiration effort;a ventilation gas delivery circuit connecting the ventilator to the trans-tracheal ventilation catheter;wherein a breathing cycle is determined by one or more signals from one or more of the one or more first sensors and the one or more second sensors; andwherein the control system activates the ventilator to deliver an increased volume of ventilation gas synchronized with the breathing cycle when apnea is detected by the one or more first sensors measuring a signal that is abnormally low and the one or more second sensors simultaneously measuring a signal that is not abnormally low. 2. The apparatus of claim 1, wherein the control system operates the ventilator such that ventilation gas is delivered in a manner selected from the group consisting of during an inspiration phase of the breathing cycle, during an expiration phase of the breathing cycle, during both an inspiration phase and an expiration phase of the breathing cycle, continuously during the breathing cycle, cyclically during the breathing cycle, with a flow amplitude that increases over time, with flow rates adjusted by the control system in response to measurements from the one or more first sensors and the one or more second sensors, and combinations thereof. 3. The apparatus of claim 1, wherein the ventilation gas is delivered at a low flow rate and a high pressure. 4. The apparatus of claim 1, wherein the ventilation gas is delivered at a high frequency. 5. The apparatus of claim 1, wherein the ventilation gas is delivered as a jet. 6. The apparatus of claim 1, wherein the ventilation gas is delivered in a manner selected from the group consisting of preemptively to prevent or minimize an obstruction or apneic event, while an obstruction or apneic event is developing, in reaction to an obstruction or apneic event, and combinations thereof. 7. The apparatus of claim 1, wherein the one or more first sensors and the one or more second sensors are coupled to the trans-tracheal ventilation catheter. 8. The apparatus of claim 1, wherein the one or more first sensors and the one or more second sensors are external to the trachea. 9. The apparatus of claim 1, wherein the one or more first sensors are one or more airflow sensors in the trachea and one or more pressure sensors in the trachea. 10. The apparatus of claim 9, wherein signals from the one or more airflow sensors and signals from the one or more pressure sensors are combined by the control system to activate the ventilator. 11. The apparatus of claim 1, further comprising a humidifier. 12. The apparatus of claim 1, wherein the trans-tracheal ventilation catheter is inserted through a stoma guide. 13. The apparatus of claim 1, wherein the distal tip curves superiorly towards the upper airway within the trachea. 14. The apparatus of claim 1, wherein the trans-tracheal ventilation catheter comprises multiple lumens with a function selected from the group consisting of delivering gas toward the lung, delivering gas toward the upper airway and away from the lung, monitoring pressure of the trachea, containing breath sensor wiring, or combinations thereof. 15. The apparatus of claim 1, wherein the distal tip comprises two ventilation gas exit ports, wherein a first gas exit port directs ventilation gas toward the lung and a second gas exit port directs gas superiorly away from the lung toward the upper airway. 16. The apparatus of claim 1, wherein the distal tip comprises a bifurcation, wherein a first part of the bifurcation is curved or angled inferiorly toward the lung and a second part of the bifurcation is curved or angled superiorly away from the lung toward the upper airway. 17. The apparatus of claim 1, wherein the ventilation apparatus operates in a first mode during daytime use for respiratory insufficiency using a first set of parameters and in a second mode during nocturnal used during sleep using a second set of parameters. 18. The apparatus of claim 1, wherein the ventilator is activated to deliver a first volume of ventilation gas synchronized with the breathing cycle when apnea is not detected and a second volume of ventilation gas synchronized with the breathing cycle when apnea is detected. 19. The apparatus of claim 18, wherein 10 ml to 200 ml of ventilation gas is delivered per ventilation cycle when apnea is not detected, and 200 ml to 500 ml of ventilation gas is delivered per ventilation cycle when apnea is detected. 20. The apparatus of claim 1, wherein the ventilator is activated to deliver a first composition of ventilation gas when apnea is not detected and a second composition of ventilation gas when apnea is detected. 21. The apparatus of claim 20, wherein the second composition of ventilation gas has a greater oxygen concentration than the first composition of ventilation gas. 22. The apparatus of claim 21, wherein the first composition of ventilation gas comprises 21 to 35% oxygen and the second composition of ventilation gas comprises 35 to 75% oxygen. 23. The apparatus of claim 1, wherein the ventilation gas is delivered at a low volume and a high frequency. 24. The apparatus of claim 23, wherein the low volume comprises a range of about 5 to 100 ml and the high frequency comprises a range of about 12 to 120 cycles per minute. 25. The apparatus of claim 23, wherein the low volume comprises a range of about 10 to 20 ml and the high frequency comprises a range of about 30 to 60 cycles per minute. 26. A method of treating sleep apnea, the method comprising: inserting a trans-tracheal ventilation catheter with a distal tip into a trachea; measuring an actual patient respiration cycle with one or more first sensors and one or more second sensors, the one or more second sensors measuring patient respiratory effort;controlling a ventilator with a control system based upon signals from the one or more of the one or more first sensors and the one or more second sensors;selectively delivering ventilation gas from the ventilator to the trans-tracheal ventilation catheter through a ventilation gas delivery circuit in synchrony with the breathing cycle as measured by the one or more first sensors, an increased volume of ventilation gas being delivered when signals of the one or more first sensors is abnormally low and simultaneously when signals of the one or more second sensors is not abnormally low; andwherein the distal tip of the trans-tracheal ventilation catheter directs the ventilation gas in a direction selected from the group consisting of superiorly from the trans-tracheal ventilation catheter towards an upper airway, inferiorly from the trans-tracheal ventilation catheter towards a lung, and combinations thereof. 27. The method of claim 26, wherein the control system operates the ventilator such that ventilation gas is delivered in a manner selected from the group consisting of during an inspiration phase of the breathing cycle, during an expiration phase of the breathing cycle, during both an inspiration phase and an expiration phase of the breathing cycle, continuously during the breathing cycle, cyclically during the breathing cycle, with a flow amplitude that increases over time, with flow rates adjusted by the control system in response to measurements from the one or more first sensors and the one or more second sensors, and combinations thereof thereof. 28. The method of claim 26, wherein the ventilation gas is delivered at a low flow rate and a high pressure. 29. The method of claim 26, wherein the ventilation gas is delivered at a high frequency. 30. The method of claim 26, wherein the ventilation gas is delivered as a jet. 31. The method of claim 26, wherein the ventilation gas is delivered in a manner selected from the group consisting of preemptively to prevent or minimize an obstruction or apneic event, while an obstruction or apneic event is developing, in reaction to an obstruction or apneic event, and combinations thereof. 32. The method of claim 26, wherein the one or more first sensors and the one or more second sensors are coupled to the trans-tracheal ventilation catheter. 33. The method of claim 26, wherein the one or more first sensors and the one or more second sensors are external to the trachea. 34. The method of claim 26, wherein the one or more first sensors are one or more airflow sensors in the trachea and one or more pressure sensors in the trachea. 35. The method of claim 26, further comprising a humidifier. 36. The method of claim 26, wherein the trans-tracheal ventilation catheter is inserted through a stoma guide. 37. The method of claim 26, wherein distal tip curves superiorly towards the upper airway within the trachea. 38. The method of claim 26, wherein the trans-tracheal ventilation catheter comprises multiple lumens with a function selected from the group consisting of delivering gas toward the lung, delivering gas toward the upper airway and away from the lung, monitoring pressure of the trachea, containing breath sensor wiring, or combinations thereof. 39. The method of claim 26, wherein the distal tip comprises two ventilation gas exit ports, wherein a first gas exit port directs ventilation gas toward the lung and a second gas exit port directs gas superiorly away from the lung toward the upper airway. 40. The method of claim 26, wherein the distal tip comprises a bifurcation, wherein a first part of the bifurcation is curved or angled inferiorly toward the lung and a second part of the bifurcation is curved or angled superiorly away from the lung toward the upper airway. 41. The method of claim 26, wherein the ventilation apparatus operates in a first mode during daytime use for respiratory insufficiency using a first set of parameters and in a second mode during nocturnal used during sleep using a second set of parameters. 42. A ventilation apparatus for treating sleep apnea, the apparatus comprising: a ventilator for delivering ventilation gas;a control system for the ventilator;a ventilation catheter for placement into fluid communication with a patient airway;a distal tip on the ventilation catheter;one or more first sensors, signals from the one or more first sensors measuring actual respiration;one or more second sensors, signals from the one or more second sensors measuring respiration effort;wherein signals from the one or more first sensors and the one or more second sensors are combined to determine a breathing cycle;a ventilation gas delivery circuit connecting the ventilator to the ventilation catheter;wherein the control system operates the ventilator to deliver an increased volume of ventilation gas synchronized with the breathing cycle when apnea is detected by the one or more first sensors measuring a signal that is abnormally low and the one or more second sensors simultaneously measuring a signal that is not abnormally low; andwherein the distal tip delivers the ventilation gas in a direction towards a lung. 43. The apparatus of claim 42, wherein the control system operates the ventilator such that ventilation gas is delivered in a manner selected from during an inspiration phase of the breathing cycle, during an expiration phase of the breathing cycle, during both an inspiration phase and an expiration phase of the breathing cycle, and combinations thereof. 44. The apparatus of claim 42, wherein the one or more first sensors measure actual respiration air movement, and the one or more second sensors directly or indirectly measure respiratory muscle effort, and wherein the control system processes the signals from the one or more first sensors and the one or more second sensors to distinguish conditions selected from the group consisting of light breathing, an obstruction, a reduced respiratory drive, and combinations thereof. 45. A method of treating sleep apnea, the method comprising; placing a ventilation catheter with a distal tip into fluid communication with a patient's airway;measuring a breathing cycle with one or more first sensors and one or more second sensors measuring patient respiratory effort;controlling a ventilator with a control system based upon signals from the one or more first sensors and the one or more second sensors;selectively delivering ventilation gas from the ventilator to the ventilation catheter through a ventilation gas delivery circuit in synchrony with the breathing cycle as measured by the one or more first sensors, an increased volume of ventilation gas being delivered when signals of the one or more first sensors is abnormally low and simultaneously when signals of the one or more second sensors is not abnormally low, low; andwherein the distal tip of the ventilation catheter directs the ventilation gas in a direction towards a lung. 46. The method of claim 45, wherein the control system operates the ventilator such that ventilation gas is delivered in a manner selected from during an inspiration phase of the breathing cycle, during an expiration phase of the breathing cycle, during both an inspiration phase and an expiration phase of the breathing cycle, and combinations thereof. 47. The method of claim 45, wherein the one or more first sensors measure actual respiration air movement, and the one or more second sensors directly or indirectly measure respiratory muscle effort, and wherein the control system processes the signals from the one or more first sensors and the one or more second sensors to distinguish conditions selected from the group consisting of light breathing, an obstruction, a reduced respiratory drive, and combinations thereof. 48. The method of claim 47, wherein the control system activates the ventilator to delivery ventilation gas if the one or more first sensors measure a signal that is abnormally low in amplitude, and the one or more second sensors simultaneously measure a signal that is not abnormally low in amplitude. 49. A ventilation apparatus for treating sleep apnea, the apparatus comprising: a ventilator for delivering ventilation gas;a control system for the ventilator;a trans-tracheal ventilation catheter for insertion into a trachea;one or more first sensors, signals from the one or more first sensors measuring actual respiration;one or more second sensors, signals from the one or more second sensors measuring respiration effort;wherein signals from the one or more first sensors and the one or more second sensors are combined to determine a breathing cycle; anda ventilation gas delivery circuit connecting the ventilator to the trans-tracheal ventilation catheter;wherein the control system operates the ventilator to deliver an increased volume of ventilation gas synchronized with the breathing cycle when apnea is detected by the one or more first sensors measuring a signal that is abnormally low and the one or more second sensors simultaneously measuring a signal that is not abnormally low. 50. The apparatus of claim 49, wherein the control system operates the ventilator such that ventilation gas is delivered in a manner selected from during an inspiration phase of the breathing cycle, during an expiration phase of the breathing cycle, during both an inspiration phase and an expiration phase of the breathing cycle and combinations thereof. 51. The apparatus of claim 49, wherein the one or more first sensors measure actual respiration air movement, and the one or more second sensors directly or indirectly measure respiratory muscle effort, and wherein the control system processes the signals from the one or more first sensors and the one or more second sensors to distinguish conditions selected from the group consisting of light breathing, an obstruction, a reduced respiratory drive, and combinations thereof. 52. A method of treating sleep apnea, the method comprising: inserting a trans-tracheal ventilation catheter into a trachea;measuring a breathing cycle with one or more first sensors and one or more second sensors measuring patient respiratory effort;controlling a ventilator with a control system based upon signals from the one or more first sensors and the one or more second sensors; andselectively delivering ventilation gas from the ventilator to the trans-tracheal ventilation catheter through a ventilation gas delivery circuit in synchrony with the breathing cycle as measured by the one or more first sensors and the one or more second sensors, an increased volume of ventilation gas being delivered when signals of the one or more first sensors is abnormally low and simultaneously when signals of the one or more second sensors is not abnormally low. 53. The method of claim 52, wherein the control system operates the ventilator such that ventilation gas is delivered in a manner selected from during an inspiration phase of the breathing cycle, during an expiration phase of the breathing cycle, during both an inspiration phase and an expiration phase of the breathing cycle, and combinations thereof. 54. The method of claim 52, wherein the one or more first sensors measure actual respiration air movement, and the one or more second sensors directly or indirectly measure respiratory muscle effort, and wherein the control system processes the signals from the one or more first sensors and the one or more second sensors to distinguish conditions selected from the group consisting of light breathing, an obstruction, a reduced respiratory drive, and combinations thereof.
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