IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0137385
(2011-08-10)
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등록번호 |
US-8962303
(2015-02-24)
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발명자
/ 주소 |
- Owen, Donald R.
- Kravitz, David C.
- Brassil, John
- Brockbank, Kelvin G. M.
- Burroughs, Andrew
- Isaacs, Dickon
- Schein, Douglas
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출원인 / 주소 |
- Lifeline Scientific, Inc.
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
0 인용 특허 :
99 |
초록
▼
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. In perfusion, organ perfusion pressure is preferably controlle
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.
대표청구항
▼
1. A kit comprising: a saleable package containing a portable housing, a set of tubes, and an organ supporting device, wherein the organ supporting device is configured to support an organ within said portable housing by way of an organ supporting surface, wherein the portable housing is configured
1. A kit comprising: a saleable package containing a portable housing, a set of tubes, and an organ supporting device, wherein the organ supporting device is configured to support an organ within said portable housing by way of an organ supporting surface, wherein the portable housing is configured to be received by at least one of an organ perfusion device, an organ transporter and an organ diagnostic device, and includes openings configured to allow the set of tubes to be connected to the organ by way of the openings, and wherein a bottom portion of the housing is liquid-tight, whereinthe organ supporting surface is a fixed surface relative to the organ supporting device,the organ supporting device and organ supporting surface are configured to be raised and lowered within the portable housing, andthe organ supporting device is configured to position a cannula connected to the organ. 2. A kit according to claim 1, wherein the set of tubes includes tubes for connecting the portable housing with an organ. 3. A kit according to claim 2, wherein the set of tubes further comprises tubes for connecting the portable housing to the organ perfusion apparatus. 4. An apparatus for holding an organ for at least one of perfusion, storage, diagnosis and transport of the organ, comprising: a portable housing;a tube set connectable to the portable housing;an organ supporting device configured to support an organ within said housing by way of an organ supporting surface, wherein the portable housing is configured to be received by at least one of an organ perfusion device, an organ transporter and an organ diagnostic device, and includes openings configured to allow the tube set to be connected to the organ by way of the openings, wherein the portable housing and the tube set can be removed from at least one of the organ perfusion device, organ transporter and organ diagnostic device without exposing the organ, and wherein a bottom portion of the portable housing is liquid-tight, whereinthe organ supporting surface is a fixed surface relative to the organ supporting device,the organ supporting device and organ supporting surface are configured to be raised and lowered within the portable housing, andthe organ supporting device is configured to position a cannula connected to the organ. 5. A system for holding an organ during perfusion, storage and transport of the organ, comprising: an organ cassette for holding the organ, the organ cassette including an organ supporting device configured to support an organ within the organ cassette by way of an organ supporting surface;the organ supporting device being configured to raise and lower the organ supporting surface within the cassette during perfusion of the organ; anda transporter having a compartment structured to receive and support the organ cassette, the transporter being a portable organ perfusion apparatus,wherein the organ cassette is configured (1) to hold the organ independently from the transporter, (2) to be received by the transporter for transport of the organ, (3) to be removed from the transporter without removal of the organ from the organ cassette, and (4) to allow perfusion, storage, and transport of the organ without removal of the organ from the organ cassette. 6. A system according to claim 5, further comprising: the organ supporting device including a portion extending upwardly from the organ supporting surface. 7. A system according to claim 6, wherein the organ supporting surface is configured to be raised and lowered during the perfusion of the organ by way of the portion of the organ supporting device extending upwardly from the organ supporting surface. 8. A system according to claim 5, further comprising: the organ supporting device including at least one side wall extending higher than the organ supporting surface. 9. A system according to claim 5, further comprising: the organ supporting device including at least one rear wall extending higher than the organ supporting surface. 10. A system according to claim 5, wherein the organ supporting surface is configured to maintain a fixed shape as the organ supporting surface is raised and lowered within the cassette during the perfusion of the organ. 11. A system according to claim 5, wherein an external surface of the organ supporting device opposite the organ supporting surface is configured to maintain a fixed distance from the organ supporting surface as the organ supporting surface is raised and lowered within the cassette during the perfusion of the organ. 12. A system for holding an organ during perfusion, storage and transport of the organ. comprising: an organ cassette for holding the organ. the organ cassette including an organ supporting device configured to support an organ within the organ cassette by wav of an organ supporting surface;the organ supporting device being configured to raise and lower the organ supporting surface within the cassette; anda transporter having a compartment structured to receive and support the organ cassette, the transporter being a portable organ perfusion apparatus,wherein the organ cassette is configured (1) to hold the organ independently from the transporter, (2) to be received by the transporter for transport of the organ, (3) to be removed from the transporter without removal of the organ from the organ cassette. and (4) to allow perfusion, storage, and transport of the organ without removal of the organ from the organ cassette. andwherein a portion of the organ supporting device that extends higher than the organ supporting surface is configured to substantially maintain a position of a cannula relative to the organ supported on the organ supporting surface.
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