Therapeutic dental composition and related methods
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-008/41
A61K-008/42
A61K-008/85
A61K-008/89
A61Q-011/00
C07C-215/10
C07C-233/18
출원번호
US-0594994
(2008-07-10)
등록번호
US-8968709
(2015-03-03)
국제출원번호
PCT/US2008/069651
(2008-07-10)
§371/§102 date
20091007
(20091007)
국제공개번호
WO2009/014907
(2009-01-29)
발명자
/ 주소
Yang, Jie
Velamakanni, Bhaskar V.
Mitra, Sumita B
Pocius, Alphonsus V.
Stofko, Jr., John J.
Yarwood, Jeremy M.
출원인 / 주소
3M Innovative Properties Company
대리인 / 주소
Einerson, Nicole J.
인용정보
피인용 횟수 :
2인용 특허 :
20
초록
Dental compositions are provided comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof: wherein n is an integer from about 2 to about 5.
대표청구항▼
1. A composition comprising a compound of Formula I and a binder, wherein R1 and R2 are independently selected from the group consisting of a hydrogen atom, an alkyl group, and C(O)R3, wherein at least one of R1 and R2 is C(O)R3;R3 is selected from the group consisting of an alkyl group having seve
1. A composition comprising a compound of Formula I and a binder, wherein R1 and R2 are independently selected from the group consisting of a hydrogen atom, an alkyl group, and C(O)R3, wherein at least one of R1 and R2 is C(O)R3;R3 is selected from the group consisting of an alkyl group having seven carbon atoms, an alkyl group having eight carbon atoms, and an alkyl group having nine carbon atoms;n is an integer from about 2 to about 5;the binder comprises a film forming polymer;the binder is soluble in a pharmaceutically acceptable carrier or solvent selected from the group consisting of water, alcohol, glycerol, or a combination thereof; andthe composition is a film forming dental composition. 2. The dental composition of claim 1 wherein R1 comprises a methyl group and R2 is C(O)R3. 3. The dental composition of claim 1 wherein R3 is selected from the group consisting of an alkyl group having seven carbon atoms, and an alkyl group having eight carbon atoms. 4. The dental composition of claim 2 wherein R3 is selected from the group consisting of an alkyl group having seven carbon atoms, and an alkyl group having eight carbon atoms. 5. The dental composition of claim 1 wherein R1 is selected from the group consisting of a hydrogen atom and an alkyl group having about one to about ten carbon atoms, and wherein R2 is C(O)R3. 6. The dental composition of claim 1 wherein the binder comprises at least one of an addition polymer or a condensation polymer. 7. The dental composition of claim 1 wherein the binder is selected from the group consisting of an acrylic polymer, a vinyl polymer, an epoxy polymer, a polyurea, a polyester, a polyanhydride, a polysiloxane, a polyurethane, and combinations thereof. 8. The dental composition of claim 1 wherein the binder comprises an acrylic polymer. 9. The dental composition of claim 1 further comprising a pharmaceutically acceptable carrier or solvent selected from the group consisting of water, alcohol, glycerol, or a combination thereof. 10. The dental composition of claim 9 wherein the carrier comprises ethanol. 11. The dental composition of claim 1 further comprising a flavoring agent, a coloring agent, or a combination thereof. 12. The dental composition of claim 1 wherein the dental composition is a therapeutic dental composition. 13. The dental composition of claim 1 wherein the dental composition is a biofilm inhibiting composition. 14. The dental composition of claim 1 wherein the composition is in a form selected from the group consisting of a solution, a dispersion, a suspension, an emulsion, a solid, a paste, a foam, and a gel. 15. The dental composition of claim 1 further comprising an additive with antimicrobial activity. 16. The dental composition of claim 15 wherein the additive with antimicrobial activity is selected from the group consisting of glycerol esters of fatty acids, salts of chlorhexidine, long chain alkyl ammonium salts, long chain alkyl pyridinium salts, hydrogen peroxide, stannous fluoride and triclosan. 17. The dental composition of claim 15 wherein the additive with antimicrobial activity is selected from the group consisting of glyceryl monolaurate, chlorhexidine gluconate and cetylpyridinium chloride. 18. The dental composition of claim 1, wherein: R1 comprises an alkyl group selected from the group consisting of methyl, ethyl, 1-propyl, iso-propyl, butyl, iso-butyl, sec-butyl, pentyl, iso-pentyl, and neo-pentyl; andR2 comprises C(O)R3. 19. The dental composition of claim 1, wherein R1 comprises methyl, wherein R2 comprises C(O)R3, and wherein R3 comprises an alkyl group having eight carbon atoms. 20. A method of inhibiting biofilm formation on a surface in the oral cavity of a subject, the method comprising: 1) providing the dental composition of claims 1; and2) applying the dental composition to a surface in the oral cavity of a subject. 21. The method of claim 20 wherein the step of applying comprises immersing, inserting, rinsing, spraying, brushing, swabbing, or combinations thereof. 22. The method of claim 20 wherein the surface is a hard surface. 23. A kit comprising: 1) the dental composition of claims 1; and2) at least one applicator selected from the group consisting of a container, a sprayer, a brush, a swab, a tray, and combinations thereof.
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