Method for picosecond and femtosecond laser tissue welding
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-018/20
A61B-017/00
A61B-018/00
출원번호
US-0642746
(2011-04-20)
등록번호
US-8974444
(2015-03-10)
국제출원번호
PCT/US2011/033231
(2011-04-20)
§371/§102 date
20130603
(20130603)
국제공개번호
WO2011/133660
(2011-10-27)
발명자
/ 주소
Alfano, Robert R.
Sriramoju, Vidyasagar
출원인 / 주소
Alfano, Robert R.
대리인 / 주소
Greenspan, Myron
인용정보
피인용 횟수 :
0인용 특허 :
7
초록▼
A method for welding tissue wounds in an animal. The method comprises joining edges of a tissue wound and irradiating the tissue wound and tissue surrounding the tissue wound with a pulsed laser. The pulsed laser has a laser wavelength in a range of an absorption band of water, elastin and/or collag
A method for welding tissue wounds in an animal. The method comprises joining edges of a tissue wound and irradiating the tissue wound and tissue surrounding the tissue wound with a pulsed laser. The pulsed laser has a laser wavelength in a range of an absorption band of water, elastin and/or collagen in the tissue wound and tissue surrounding the tissue wound. The pulsed laser has a pulse width of not more than picoseconds in order of magnitude to heat tissue surrounding the tissue wound and facilitate bonding of native tissue protein present in the tissue surrounding the tissue wound to achieve tissue repair. The laser wavelength is in a range of between about 800 nm to about 2,700 nm.
대표청구항▼
1. A method for welding tissue wounds in an animal/human, comprising: joining edges of a tissue wound; andirradiating the tissue wound and tissue surrounding the tissue wound with a pulsed laser, the pulsed laser having a laser wavelength in a range of an absorption band of native tissue molecules o
1. A method for welding tissue wounds in an animal/human, comprising: joining edges of a tissue wound; andirradiating the tissue wound and tissue surrounding the tissue wound with a pulsed laser, the pulsed laser having a laser wavelength in a range of an absorption band of native tissue molecules of water, elastin and/or collagen in the tissue wound and the tissue surrounding the tissue wound, said pulsed laser having a pulse width of not more than picoseconds in order of magnitude, said pulsed laser non-thermally inducing vibration modes of tissue surrounding the tissue wound and facilitates bonding of native tissue protein present in the tissue surrounding the tissue wound to achieve tissue repair. 2. The method of claim 1, wherein the laser wavelength is in a range of between about 800 nm to about 2,700 nm to photon excite vibrational modes of water, collagen or elastin from absorption. 3. The method of claim 1, wherein said pulsed laser is a picosecond laser. 4. The method of claim 1, wherein said pulsed laser is a femtosecond laser. 5. The method of claim 1, where said pulsed laser has a pulse width of less than 10 picoseconds. 6. The method of claim 1, wherein the tissue wound is to tissue selected from a group consisting of skin, mucosal tissue, bone, blood vessels, artery, neural tissue, hepatic tissue, pancreatic tissue, splenic tissue, renal tissue, bronchial tissue, tissues of the respiratory tract, tissues of the urinary tract, tissues of the gastrointestinal tract and tissues of the gynecologic tract. 7. The method of claim 6, wherein the tissue wound is a fistula of the gastrointestinal tract. 8. The method of claim 6, wherein the tissue wound is a fistula of the urinary tract. 9. The method of claim 6, wherein the tissue wound is air leak in pulmonary tissue. 10. A method for welding tissue wounds in an animal/human comprising: joining edges of a tissue wound; and irradiating the tissue wound and tissue surrounding the tissue wound with a picosecond or a femtosecond pulsed laser, said picosecond or said femtosecond pulsed laser irradiated energy being selected to be within a range of absorption of native tissue molecules for non-thermally inducing molecular crosslinking of native tissue proteins surrounding the tissue wound and facilitates bonding of native tissue proteins present in the tissue surrounding the tissue wound to achieve tissue fusion. 11. The method of claim 10, wherein said picosecond or said femtosecond pulsed laser is selected from a group consisting of picosecond or femtosecond solid state lasers, semiconductor lasers and fiber lasers, YAG glass lasers, and parametric oscillator lasers. 12. The method of claim 10, wherein said picosecond or said femtosecond pulsed laser is tuned to a spectral range which corresponds to an absorption band of water in the tissue wounds and tissue proteins surrounding the wounds at wavelengths about 1064+1−30 nm, 1450+/−30rn n, 1560+/−30nm, 1950+/−30nm and 2400+/−30nm. 13. The method of claim 12, wherein in said irradiating, said water in the tissue wound and the tissue proteins surrounding the tissue wound absorbs energy from said picosecond or femtosecond pulsed laser by vibrational overtones and combinations of primary modes (v1, v2, v3) and non-thermally excites water mediated hydrogen bonds in collagen and elastin molecules due to energy transfer and wherein said picosecond or said femtosecond pulsed laser have wavelengths of about 1560+/−30 nm and energy at these wavelength excites a combination mode (1, 0, 1) of water and wavelengths of about 1064+/−30 nm excites a combination mode(1, 1, 1). 14. The method of claim 10, wherein said picosecond or said femtosecond pulsed laser is tuned to a spectral range which corresponds to an absorption band of collagen in the tissue wounds and tissue proteins surrounding the tissue wounds at wavelengths about 1750+/−30nm, 2050+/−30nm, 2200+/−30nm, and 2300+/−30nm. 15. The method of claim 14, wherein in said irradiating, said tissue proteins absorb energy from said picosecond or said femtosecond pulsed laser by vibrational overtones and combinations modes(v1, v2, v3) and non-thermally excites collagen molecules by direct energy transfer and wherein energy of said picoseconds or said femtosecond pulsed laser at these wavelengths excites combination modes, and overtone vibrational modes of the collagen. 16. The method of claim 10, where said picosecond or said femtosecond pulsed laser is tuned a spectral range which corresponds to an absorption band of elastin in the tissue wound and tissue proteins surrounding the tissue wound at wavelengths about 1700+/−30nm, 2050+/−30nm, 2200+/−30nm, and 2300+/−30nm. 17. The method of claim 16, wherein in said irradiating, said tissue proteins absorb energy from said picosecond or said femtosecond pulsed laser by vibrational overtones and combinations rnodes(v1, v2, v3) and non-thermally excites elastin molecules by direct energy transfer and wherein energy of said picosecond or said femtosecond pulsed laser at these wavelengths excites combination modes, and overtone vibrational modes of the elastin. 18. The method of claim 10, wherein average power of said picosecond or said femtosecond pulsed laser is in a range of about 40 milliwatts to about 5400 milliwatts to induce non-thermal mechanisms of reversible dissociation of intramolecular, inteituolecular hydrogen bonds, electrostatic interactions in tissue proteins surrounding said tissue wound. 19. The method of claim 10, wherein average power of said picosecond and said femtosecond pulsed lasers is in a range of about 100 milliwatts to about 1600 milliwatts to induce non-thermal vibrations of intramolecular, intermolecular hydrogen bonds, electrostatic interactions in tissue proteins surrounding said tissue wound. 20. The method of claim 10, wherein said tissue wound is to tissue selected from a group consisting of skin, mucosal tissue, bone, blood vessels, artery, neural tissue, hepatic tissue, pancreatic tissue, splenic tissue, renal tissue, bronchial tissue, tissues of the respiratory tract, tissues of the urinary tract, tissues of the gastrointestinal tract and tissues of the gynecologic tract, tissues of male reproductive system. 21. The method of claim 10, wherein said picosecond or femtosecond pulsed laser has a pulse width of less than 10 ps for tissue welding using a wavelength in a range of about 900 nm to about 2700 nm. 22. The method of claim 10, wherein both picosecond and femtosecond pulses are emitted from said picosecond or femtosecond pulsed laser. 23. The method of claim 10, wherein a plurality of picosecond or femtosecond pulsed lasers irradiate the tissue wound and tissue surrounding the tissue wound. 24. A method for welding tissue wounds in animals comprising the steps of: joining edges of a tissue wound; and irradiating the tissue wound and tissue surrounding the tissue wound with a picosecond or a femtosecond pulsed laser, said picosecond or said femtosecond pulsed laser irradiated energy being selected to be within a range of absorption of native tissue molecules inducing molecular crosslinking of native tissue proteins surrounding the tissue wound and facilitates bonding of native tissue proteins present in the tissue surrounding the tissue wound to achieve tissue fusion, said picosecond or said femtosecond pulsed laser being tuned to a spectral range which corresponds to an absorption band of collagen in the tissue wound and tissue proteins surrounding the tissue wounds causing said tissue proteins to absorb energy from said picosecond or said femtosecond pulsed laser by vibrational overtones and combination modes and non-thermally excites collagen molecules by direct energy transfer and wherein energy of said picoseconds or said femtosecond pulsed laser at these wavelengths excites combination modes, and overtone vibrational modes of the collagen.
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