초록 ▼

The present invention provides a sensor apparatus based on 2D films or 3D assemblies of cubic nanoparticles capped with an organic coating. The apparatus is used to determine the composition and preferably measure the concentration of volatile and non-volatile compounds in a sample, with very high s

The present invention provides a sensor apparatus based on 2D films or 3D assemblies of cubic nanoparticles capped with an organic coating. The apparatus is used to determine the composition and preferably measure the concentration of volatile and non-volatile compounds in a sample, with very high sensitivity. Methods for use of the apparatus in applications such as diagnosis of disease, food quality and environmental control are disclosed.

대표청구항 ▼

1. A system having: (i) an apparatus comprising an array of chemically sensitive sensors comprising a plurality of cubic nanoparticle conductive cores, comprising six facets and capped with an organic coating, wherein the cubic nanoparticle conductive cores capped with an organic coating are ordered

1. A system having: (i) an apparatus comprising an array of chemically sensitive sensors comprising a plurality of cubic nanoparticle conductive cores, comprising six facets and capped with an organic coating, wherein the cubic nanoparticle conductive cores capped with an organic coating are ordered in a configuration selected from 1D wires, 2D films and 3D assemblies having minimized voids and essentially full interface contacts between adjacent facets of the cubic nanoparticle conductive cores capped with an organic coating, wherein the chemically sensitive sensors detect volatile and non-volatile compounds through swelling or aggregation of the cubic nanoparticles upon analyte adsorption thereon; and(ii) a learning and pattern recognition analyzer, wherein said learning and pattern recognition analyzer receives sensor output signals and compares them to stored data. 2. The system according to claim 1, wherein the cubic nanoparticle conductive cores are capped with an organic coating comprising a monolayer or multilayers of organic compounds, wherein the organic compounds are selected from small molecules, monomers, oligomers and polymers. 3. The system according to claim 1, wherein the cubic nanoparticle conductive cores are selected from the group consisting of Au, Ag, Ni, Co, Pt, Pd, Cu, Al, Au/Ag, Au/Cu, Au/Ag/Cu, Au/Pt, Au/Pd, Au/Ag/Cu/Pd, Pt/Rh, Ni/Co, and Pt/Ni/Fe. 4. The system according to claim 1, wherein the organic coating is selected from the group consisting of alkylthiols with C3-C24 chains, ω-functionalized alkanethiolates, arenethiolate, (γ-mercaptopropyl)tri-methyloxysilane, dialkyl disulfides, xanthates, oligonucleotides, polynucleotides, peptides, proteins, enzymes, polysaccharides, phospholipids, and combinations thereof. 5. The system according to claim 1, further comprising at least one of a chemiresistor, chemicapacitor, quartz crystal microbalance, bulk acoustic wave (BAW) and surface acoustic wave (SAW) resonator, electrochemical cell, surface plasmon resonance (SPR), and optical spectroscope. 6. The system according to claim 1, wherein the learning and pattern recognition analyzer comprises at least one algorithm selected from the group consisting of artificial neural network algorithms, principal component analysis (PCA), multi-layer perception (MLP), generalized regression neural network (GRNN), fuzzy inference systems (FIS), self-organizing map (SOM), radial bias function (RBF), genetic algorithms (GAS), neuro-fuzzy systems (NFS), adaptive resonance theory (ART), partial least squares (PLS), multiple linear regression (MLR), principal component regression (PCR), discriminant function analysis (DFA), linear discriminant analysis (LDA), cluster analysis, and nearest neighbor. 7. A method for determining at least one of the composition and concentration of selected volatile and non-volatile compounds in a sample, comprising the steps of: (i) providing a system comprising an apparatus comprising an array of chemically sensitive sensors comprising a plurality of cubic nanoparticle conductive cores, comprising six facets and capped with an organic coating, wherein the cubic nanoparticle conductive cores capped with an organic coating are ordered in a configuration selected from 1D wires, 2D films and 3D assemblies having minimized voids and essentially full interface contacts between adjacent facets of the cubic nanoparticle conductive cores capped with an organic coating, wherein the chemically sensitive sensors detect volatile and non-volatile compounds through swelling or aggregation of the cubic nanoparticles upon analyte adsorption thereon, and a learning and pattern recognition analyzer, wherein the learning and pattern recognition analyzer receives sensor output signals and compares them to stored data;(ii) exposing the sensor array of the apparatus to the sample; and(iii) using pattern recognition algorithms to detect the presence of volatile and non-volatile compounds in the sample. 8. The method according to claim 7, for detecting volatile and non-volatile compounds indicative of a disease in a subject. 9. The method according to claim 8, wherein the disease is selected from the group consisting of cancer, acute asthma, hepatic encephalopathy, rheumatoid arthritis, renal failure, schizophrenia, ketosis, cardiopulmonary disease, uremia, diabetes mellitus, dysgeusia/dysosmia, cystinuria, cirrhosis, histidinemia, tyrosinemia, halitosis and phenylketonuria. 10. The method according to claim 8, for differentiating between different types of cancer. 11. The method according to claim 8, wherein the sample comprises at least one bodily fluid or secretion selected from the group consisting of serum, urine, feces, sweat, vaginal discharge, saliva, and sperm. 12. The method according to claim 7, for detecting volatile and non-volatile compounds indicative of spoilage in food products. 13. The method according to claim 7, for detecting volatile and non-volatile compounds indicative of environmental pollution. 14. The method according to claim 7 comprising measuring a response selected from an electronic response and optical response. 15. An apparatus comprising: an array of chemically sensitive sensors comprising a plurality of cubic nanoparticle conductive cores, comprising six facets and capped with an organic coating, wherein the cubic nanoparticle conductive cores capped with an organic coating are ordered in a configuration selected from 1D wires, 2D films and 3D assemblies having minimized voids and essentially full interface contacts between adjacent facets of the cubic nanoparticle conductive cores capped with an organic coating, wherein the chemically sensitive sensors detect volatile and non-volatile compounds with sensitivity of less than one part per million (ppm) through swelling or aggregation of the cubic nanoparticles upon analyte adsorption thereon. 16. The apparatus according to claim 15, wherein the cubic nanoparticle conductive cores are capped with an organic coating comprising a monolayer or multilayers of organic compounds, wherein the organic compounds are selected from small molecules, monomers, oligomers and polymers. 17. The apparatus according to claim 15, wherein the cubic nanoparticle conductive cores are selected from the group consisting of Au, Ag, Ni, Co, Pt, Pd, Cu, Al, Au/Ag, Au/Cu, Au/Ag/Cu, Au/Pt, Au/Pd, Au/Ag/Cu/Pd, Pt/Rh, Ni/Co, and Pt/Ni/Fe. 18. The apparatus according to claim 15, wherein the organic coating is selected from the group consisting of alkylthiols with C3-C24 chains, ω-functionalized alkanethiolates, arenethiolate, (γ-mercaptopropyl)tri-methyloxysilane, dialkyl disulfides, xanthates, oligonucleotides, polynucleotides, peptides, proteins, enzymes, polysaccharides, phospholipids, and combinations thereof. 19. The apparatus according to claim 15, further comprising at least one of a chemiresistor, chemicapacitor, quartz crystal microbalance, bulk acoustic wave (BAW) and surface acoustic wave (SAW) resonator, electrochemical cell, surface plasmon resonance (SPR), and optical spectroscope.