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Compositions and methods of delivery of pharmacological agents 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-047/42
  • A61K-009/14
  • A61K-009/51
  • C07K-014/76
  • A61P-035/00
  • A61K-009/00
  • A61K-009/107
  • A61K-009/19
  • A61K-031/05
  • A61K-031/16
  • A61K-031/337
  • A61K-047/18
  • B82Y-005/00
  • A61K-031/164
  • A61K-031/165
  • A61K-031/198
  • A61K-031/343
  • A61K-031/355
  • A61K-031/427
  • A61K-031/436
  • A61K-031/4745
  • A61K-031/7048
  • A61K-038/13
출원번호 US-0777980 (2013-02-26)
등록번호 US-9012518 (2015-04-21)
발명자 / 주소
  • Desai, Neil P.
  • Soon-Shiong, Patrick
  • Trieu, Vuong
출원인 / 주소
  • Abraxis BioScience, LLC
대리인 / 주소
    Morrison & Foerster LLP
인용정보 피인용 횟수 : 20  인용 특허 : 78

초록

The present invention relates to a pharmaceutical composition comprising a pharmaceutical agent and a pharmaceutically acceptable carrier, which carrier comprises a protein, for example, human serum albumin and/or deferoxamine. The human serum albumin is present in an amount effective to reduce one

대표청구항

1. A method of treating cancer in a human individual, comprising injecting into the individual an effective amount of a pharmaceutical composition comprising paclitaxel and a pharmaceutically acceptable carrier, wherein the pharmaceutically acceptable carrier comprises albumin, wherein the albumin a

이 특허에 인용된 특허 (78)

  1. Hunter William L.,CAX ; Machan Lindsay S.,CAX ; Arsenault A. Larry,CAX, Anti-angiogenic Compositions and methods for the treatment of arthritis.
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  5. De Tommaso Vincenzo,ITX, Clear, injectable formulation of an anesthetic compound.
  6. Desai, Neil P.; Soon-Shiong, Patrick, Combinations and modes of administration of therapeutic agents and combination therapy.
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  8. Desai, Neil P.; Soon-Shiong, Patrick, Combinations and modes of administration of therapeutic agents and combination therapy.
  9. Desai, Neil P.; Soon-Shiong, Patrick, Combinations and modes of administration of therapeutic agents and combination therapy.
  10. Grinstaff Mark W. (Pasadena CA) Soon-Shiong Patrick (Los Angeles CA) Wong Michael (Champaign IL) Sandford Paul A. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Desai Neil P. (Los Angeles CA), Composition useful for in vivo delivery of biologics and methods employing same.
  11. Desai, Neil P.; Soon-Shiong, Patrick, Compositions and methods for administration of pharmacologically active compounds.
  12. De, Tapas; Desai, Neil P.; Yang, Andrew; Yim, Zachary; Soon-Shiong, Patrick, Compositions and methods for preparation of poorly water soluble drugs with increased stability.
  13. De, Tapas; Desai, Neil P.; Yang, Andrew; Yim, Zachary; Soon-Shiong, Patrick, Compositions and methods for preparation of poorly water soluble drugs with increased stability.
  14. Hunter, William L.; Machan, Lindsay S., Compositions and methods for treating or preventing diseases of body passageways.
  15. Desai, Neil P.; Soon-Shiong, Patrick; Trieu, Vuong, Compositions and methods of delivery of pharmacological agents.
  16. Desai, Neil P.; Soon-Shiong, Patrick; Trieu, Vuong, Compositions and methods of delivery of pharmacological agents.
  17. Desai, Neil P.; Soon-Shiong, Patrick; Trieu, Vuong, Compositions and methods of delivery of pharmacological agents.
  18. Desai, Neil P.; Soon-Shiong, Patrick; Trieu, Vuong, Compositions and methods of delivery of pharmacological agents.
  19. Desai, Neil P.; Soon-Shiong, Patrick; Trieu, Vuong, Compositions and methods of delivery of pharmacological agents.
  20. Desai, Neil P.; Selvaraj, Raj; Yang, Andrew; Soon-Shiong, Patrick, Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents.
  21. Brem Henry (Lutherville MD) Langer Robert S. (Newton MA) Domb Abraham J. (Efrat ILX), Controlled local delivery of chemotherapeutic agents for treating solid tumors.
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  23. Sojomihardjo, Soebianto A.; Desai, Neil P.; Sandford, Paul A.; Soon-Shiong, Patrick; Nagrani, Shubhi, Crosslinkable polypeptide compositions.
  24. Karel J. Lambert ; Panayiotis P. Constantinides ; Steven C. Quay, Emulsion vehicle for poorly soluble drugs.
  25. Trissel Lawrence A. (Houston TX), Extended stability formulations for paclitaxel.
  26. Desai, Neil P.; Tao, Chunlin; Yang, Andrew; Louie, Leslie; Soon-Shiong, Patrick, Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof.
  27. Takahashi Keietsu (Itami JPX) Ueda Nobuo (Kawanishi JPX) Hazue Masaaki (Amagasaki JPX) Yokoyama Akira (Otsu JPX) Ohmomo Yoshiro (Kyoto JPX), Increasing labeling efficiency by forming diagnostic agent in the presence of ascorbic acid or the like.
  28. Desai Neil P. (Los Angeles CA) Soon-Shiong Patrick (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Grinstaff Mark W. (Pasadena CA) Suslick Kenneth S. (Champaign IL), Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell.
  29. Rothbard Jonathan B. ; Wender Paul A., Method and composition for enhancing transport across biological membranes.
  30. Yen Richard C. K., Method for making non-crosslinked protein particles for therapeutic and diagnostic use.
  31. Grinstaff Mark W. (Pasadena CA) Desai Neil P. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Soon-Shiong Patrick (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Merideth Noma R. (Pacific Palis, Method for the preparation of fluorocarbon-containing polymeric shells for medical imaging.
  32. Falciani, Marco, Method for the treatment of solid tumors by albumin microparticles incorporating paclitaxel.
  33. Desai, Neil P.; Soon-Shiong, Patrick; De, Tapas, Methods and compositions for treating proliferative diseases.
  34. Desai, Neil P.; Soon-Shiong, Patrick; De, Tapas K., Methods and compositions for treating proliferative diseases.
  35. Desai Neil P. ; Soon-Shiong Patrick, Methods and compositions useful for administration of chemotherapeutic agents.
  36. Desai, Neil P.; Soon-Shiong, Patrick, Methods and formulations of cremophor-free taxanes.
  37. Unger Evan C., Methods for delivering bioactive agents to regions of elevated temperatures.
  38. Grinstaff Mark W. (Pasadena CA) Soon-Shiong Patrick (Los Angeles CA) Wong Michael (Champagne IL) Sandford Paul A. (Los Angeles CA) Suslick Kenneth S. (Champagne IL) Desai Neil P. (Los Angeles CA), Methods for in vivo delivery of nutriceuticals and compositions useful therefor.
  39. Desai Neil P. (Los Angeles CA) Soon-Shiong Patrick (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Grinstaff Mark W. (Pasadena CA) Suslick Kenneth S. (Champaign IL), Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful th.
  40. Soon-Shiong Patrick (Los Angeles CA) Desai Neil P. (Los Angeles CA) Grinstaff Mark W. (Pasadena CA) Sandford Paul A. (Los Angeles CA) Suslick Kenneth S. (Champaign IL), Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful th.
  41. Grinstaff Mark W. (Pasadena CA) Soon-Shiong Patrick (Los Angeles CA) Wong Michael (Champaign IL) Sandford Paul A. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Desai Neil P. (Los Angeles CA), Methods for the preparation of blood substitutes for in vivo delivery.
  42. Grinstaff Mark W. (Pasadena CA) Soon-Shiong Patrick (Los Angeles CA) Wong Michael (Champagne IL) Sandford Paul A. (Los Angeles CA) Suslick Kenneth S. (Champagne IL) Desai Neil P. (Los Angeles CA), Methods for the preparation of immunostimulating agents for in vivo delivery.
  43. Grinstaff Mark W. (Pasadena CA) Soon-Shiong Patrick (Los Angeles CA) Wong Michael (Champaign IL) Sandford Paul A. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Desai Neil P. (Los Angeles CA), Methods for the preparation of nucleic acids for in vivo delivery.
  44. Grinstaff Mark W. (Pasadena CA) Soon-Shiong Patrick (Los Angeles CA) Wong Michael (Champaign IL) Sandford Paul A. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Desai Neil P. (Los Angeles CA), Methods for the preparation of pharmaceutically active agents for in vivo delivery.
  45. Spenlehauer Gilles,FRX ; Veillard Michel,FRX ; Verrechia Thierry,FRX, Microspheres, process for their preparation and their use.
  46. Grinstaff Mark W. (Pasadena CA) Desai Neil P. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Soon-Shiong Patrick (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Merideth Noma R. (Pacific Palis, Non-fluorinated polymeric shells for medical imaging.
  47. Desai, Neil P.; Soon-Shiong, Patrick, Paclitaxel-containing formulations.
  48. Westesen Kirsten,DEX ; Siekmann Britta,SEX, Particles with modified physicochemical properties, their preparation and uses.
  49. Hegedus, Lajos; Krempels, Krisztina; Paal, Krisztina; Petho, Gabor, Pharmaceutical compositions containing plasma protein.
  50. Hegedus,Lajos; Krempels,Krisztina; Paal,Krisztina; Petho,Gabor, Pharmaceutical compositions containing plasma protein.
  51. Jones Christopher Buchan,GBX ; Platt John Henry,GBX, Pharmaceutical compositions of propofol and edetate.
  52. Jones Christopher Buchan,GBX ; Platt John Henry,GBX, Pharmaceutical compositions of propofol and edetate.
  53. Ueda Yasutsugu (Clinton CT) Wong Henry (Durham CT) Farina Vittorio (West Hartford CT) Mikkilineni Amarendra (Easton PA) Vyas Dolatrai M. (Madison CT) Doyle Terrence (Killingworth CT), Phosphonooxy and carbonate derivatives of taxol.
  54. Zhong Sheng-Ping, Polycarbonate-polyurethane dispersions for thromobo-resistant coatings.
  55. Grinstaff Mark W. (Pasadena CA) Desai Neil P. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Soon-Shiong Patrick (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Merideth Noma R. (Pacific Palis, Polymeric shells for medical imaging prepared from synthetic polymers, and methods for the use thereof.
  56. Fessi Curt (Paris FRX) Devissaguet Jean-Philippe (Neuilly S/Seine FRX) Puisieux Francis (Maisons Alfort MO FRX) Thies Curt (St. Louis MO), Process for the preparation of dispersible colloidal systems of a substance in the form of nanoparticles.
  57. Stainmesse Serge (Choisy Le Roi FRX) Fessi Hatem (Paris FRX) Devissaguet Jean-Phillppe (Neuilly S/Seine FRX) Puisieux Francis (Maisons Alfort MO FRX) Theis Curt (Saint Louis MO), Process for the preparation of dispersible colloidal systems of a substance in the form of nanoparticles.
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  61. Jones Christopher Buchan,GBX ; Platt John Henry,GBX, Propofol compostion containing edetate.
  62. George Mary Mathew ; Yuen Pui-Ho ; Joyce Martin A., Propofol formulation containing TRIS.
  63. Pejaver Satish K. ; Motheram Rajeshwar ; Rabinow Barrett E. ; dela Rosa Josben C., Propofol formulation with enhanced microbial characteristics.
  64. Jack Yongfeng Zhang ; Jie Fei Ding ; Mary Zi-ping Luo, Propofol formulation with enhanced microbial inhibition.
  65. Carpenter John R., Propofol-based anesthetic and method of making same.
  66. Desai Neil P. ; Tao Chunlin ; Yang Andrew ; Louie Leslie ; Zheng Tianli ; Yao Zhiwen ; Soon-Shiong Patrick ; Magdassi Shlomo,ILX, Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof.
  67. Desai, Neil P.; Tao, Chunlin; Yang, Andrew; Louie, Leslie; Yao, Zhiwen; Soon-Shiong, Patrick; Magdassi, Shlomo, Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof.
  68. Trieu,Vuong; Desai,Neil P.; Soon Shiong,Patrick, Q3 SPARC deletion mutant and uses thereof.
  69. Yokoyama Akira (Otsu JPX) Omomo Yoshiro (Kyoto JPX) Tanaka Hisashi (Ashiya JPX) Saji Hideo (Kyoto JPX), Radioactive diagnostic agent and non-radioactive carrier therefor.
  70. Kaufman Robert J. (University City MO) Richard Thomas J. (University City MO) Fuhrhop Ralph W. (St. Louis MO), Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same.
  71. Liversidge Gary G. (West Chester PA) Liversidge Elaine (West Chester PA) Sarpotdar Pramod P. (Malvern PA), Surface modified anticancer nanoparticles.
  72. Magdassi Shlomo,ILX ; Yang Andrew ; Tao Chunlin ; Desai Neil P. ; Yao Zhiwen ; Soon-Shiong Patrick, Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof.
  73. Magdassi, Shlomo; Yang, Andrew; Tao, Chunlin; Desai, Neil P.; Yao, Zhiwen; Soon-Shiong, Patrick, Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof.
  74. Sutton Andrew Derek,GBX ; Malik Asrar Bari ; Tiruppathi Chinnaswamy ; Johnson Richard Alan,GBX, Transcytosis vehicles and enchancers for drug delivery.
  75. Wood John G. ; Samson Frederick E., Ultrasonicated .alpha.-lipoic acid solutions for attenuating microvascular injury.
  76. Chun Li ; Sidney Wallace ; Dong-Fang Yu ; David J. Yang, Water soluble paclitaxel derivatives.
  77. Li Chun ; Wallace Sidney ; Yu Dong-Fang ; Yang David J., Water soluble paclitaxel prodrugs.
  78. Sheldon S. Hendler, Water-soluble prodrugs of propofol for treatment of migrane.

이 특허를 인용한 특허 (20)

  1. Desai, Neil P.; Soon-Shiong, Patrick, Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane.
  2. Desai, Neil P.; Soon-Shiong, Patrick, Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane.
  3. Desai, Neil P.; Soon-Shiong, Patrick, Combinations and modes of administration of therapeutic agents and combination therapy.
  4. De, Tapas; Desai, Neil P; Yang, Andrew; Yim, Zachary; Soon-Shiong, Patrick, Compositions and methods for preparation of poorly water soluble drugs with increased stability.
  5. Trieu, Vuong; De, Tapas K., Immediate release phospholipid-coated therapeutic agent nanoparticles and related methods.
  6. Seward, Kirk; Desai, Neil P., Intravascular delivery of nanoparticle compositions and uses thereof.
  7. Seward, Kirk; Desai, Neil P., Intravascular delivery of nanoparticle compositions and uses thereof.
  8. Yeo, Winnie; Wong, Nathalie, Methods for treating hepatocellular carcinoma.
  9. Desai, Neil P., Methods of treating bladder cancer.
  10. Desai, Neil P.; Soon-Shiong, Patrick, Methods of treating cancer.
  11. Desai, Neil P.; Soon-Shiong, Patrick, Methods of treating cancer.
  12. Desai, Neil P.; Renschler, Markus, Methods of treating pancreatic cancer.
  13. Desai, Neil P.; Renschler, Markus, Methods of treating pancreatic cancer.
  14. Desai, Neil P.; Soon-Shiong, Patrick, Methods of treatment of pancreatic cancer.
  15. Desai, Neil P.; Soon-Shiong, Patrick, Methods of treatment of pancreatic cancer.
  16. Desai, Neil P.; Soon-Shiong, Patrick, Methods of treatment of pancreatic cancer.
  17. Desai, Neil P.; Peykov, Viktor; Soon-Shiong, Patrick, Prion free nanoparticle compositions and methods of making thereof.
  18. Desai, Neil P.; Peykov, Viktor; Soon-Shiong, Patrick, Prion free nanoparticle compositions and methods of making thereof.
  19. Foss, Willard; Shinde, Rajesh, Use of polymeric excipients for lyophilization or freezing of particles.
  20. Foss, Willard; Shinde, Rajesh, Use of polymeric excipients for lyophilization or freezing of particles.
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