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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0725894 (2012-12-21) |
| 등록번호 | US-9028472 (2015-05-12) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 7 인용 특허 : 1038 |
Medical devices and methods for making and using the same are disclosed. An example method may include renal-denervation treatment method. The method may include delivering an RF energy treatment to a tissue proximate a renal artery using a catheter assembly of a renal denervation catheter system. T
Medical devices and methods for making and using the same are disclosed. An example method may include renal-denervation treatment method. The method may include delivering an RF energy treatment to a tissue proximate a renal artery using a catheter assembly of a renal denervation catheter system. The denervation system may include an RF energy generator coupled with the catheter assembly by a controller. The method may also include applying neural activity stimulation to the tissue proximate the renal artery using the catheter assembly, assessing stimulated neural activity response of the tissue using the catheter assembly, and determining a parameter of the RF energy treatment based on the assessed neural activity.
1. A renal-denervation treatment method, comprising: (a) delivering an RF energy treatment to a tissue proximate a renal artery using a catheter assembly of a renal denervation catheter system, wherein the denervation system includes an RF energy generator coupled with the catheter assembly by a con
1. A renal-denervation treatment method, comprising: (a) delivering an RF energy treatment to a tissue proximate a renal artery using a catheter assembly of a renal denervation catheter system, wherein the denervation system includes an RF energy generator coupled with the catheter assembly by a controller;(b) applying neural activity stimulation to the tissue proximate the renal artery using the catheter assembly;(c) assessing stimulated neural activity response of the tissue using the catheter assembly; and(d) determining a parameter of the RF energy treatment based on the assessed neural activity. 2. The method of claim 1, further comprising outputting data relating to the assessed neural activity. 3. The method of claim 2, wherein outputting data comprises outputting whether a sufficient decrease in neural activity has occurred. 4. The method of claim 1, wherein assessing the neural activity comprises taking at least a first neural activity measurement and a second neural activity measurement. 5. The method of claim 4, wherein taking the first neural activity measurement comprises taking the first neural activity measurement before beginning the delivery of the RF energy treatment to establish a base line neural activity measurement; wherein taking the second neural activity measurement comprises taking the second neural activity measurement after beginning the delivery of the RF energy treatment; and wherein the method further comprises determining whether neural activity has changed from the base line. 6. The method of claim 5, wherein determining whether neural activity has changed from the base line comprises determining whether the change in neural activity is at, above or below a threshold. 7. The method of claim 6, further comprising terminating the RF energy treatment once the change in neural activity is at or above the threshold. 8. The method of claim 1, wherein assessing stimulated neural activity response comprises periodically measuring for stimulated neural activity response during the RF energy treatment. 9. The method of claim 1, wherein applying neural activity stimulation comprises energizing at least one electrode of the catheter assembly; and wherein assessing stimulated neural activity response comprises using a second electrode of the catheter assembly to monitor for the nerve response signal. 10. The method of claim 9, wherein delivering the RF energy treatment comprises using the at least one electrode and the second electrode to deliver RF energy to the tissue. 11. The method of claim 9, wherein monitoring for the nerve response signal comprises at least one of measuring an amplitude of the nerve response signal, measuring a time delay between the nerve stimulation signal and the nerve response signal, and measuring a fractionated amplitude of the nerve response signal. 12. The method of claim 9, further comprising measuring at least one of an amplitude of the nerve response signal, a pulse width of the nerve response signal, a slope or change in slope of the nerve response signal, a velocity of the nerve response signal, or a time delay of the nerve response signal. 13. The method of claim 12, further comprising comparing the measurement to a base line measurement of an earlier nerve response signal. 14. The method of claim 1, wherein determining the at least one parameter of the RF energy treatment comprises adjusting the at least one parameter based on the assessed neural activity. 15. The method of claim 14, wherein adjusting the at least one parameter comprises adjusting a temperature profile of the RF energy treatment. 16. The method of claim 15, wherein adjusting the at least one parameter comprises adjusting a length of time at a target temperature of the target temperature profile. 17. A renal-denervation method, comprising: (a) applying a first neural activity stimulation to a tissue proximate a catheter assembly of a renal denervation system;(b) measuring a first stimulated neural activity response of the tissue using the catheter assembly; and(c) delivering an energy treatment to the tissue proximate the renal artery using the catheter assembly;(d) measuring a second neural activity response of the neural tissue using the catheter assembly; and(e) determining a parameter of the energy treatment by comparing the first and second measured neural activities. 18. A renal-denervation treatment system, comprising: (a) an elongate catheter including an expandable structure at or near a distal end of the catheter, the expandable structure including a plurality of electrodes;(b) a power source electrically coupled to the plurality of electrodes; and(c) a processor configured to (1) energize at least a subset of the electrodes at a renal-denervation energy level; (2) energize one or more of the electrodes at a neural activity stimulation level; and (3) monitor for, using one or more of the electrodes, a neural activity response. 19. The system of claim 18, wherein the neural activity stimulation level is a voltage in the range of about 0.1 V to about 5 V applied for about 1 second or less. 20. The method of claim 19, wherein the neural activity stimulation level is about 0.5 V applied for about 0.5 milliseconds.
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