초록 ▼

An emulsion is provided including: an oil component and a water component, the oil component including: fish oil triglycerides in an amount of about 60% to about 90% based on the weight of the oil component; wherein the fish oil triglycerides include omega-3 fatty acids, expressed as triglycerides,

An emulsion is provided including: an oil component and a water component, the oil component including: fish oil triglycerides in an amount of about 60% to about 90% based on the weight of the oil component; wherein the fish oil triglycerides include omega-3 fatty acids, expressed as triglycerides, in an amount of at least 60%, based on the total weight of the fatty acids of the fish oil triglycerides; wherein the fish oil triglycerides include a total amount of EPA and DHA, expressed as triglycerides, of at least 45%, based on the total weight of the fatty acids of the fish oil triglycerides; and, at least one medium-chain triglyceride, wherein a total amount of the at least one medium-chain triglyceride is from about 10% to about 40% based on the weight of the oil component.

대표청구항 ▼

1. An oil-in-water emulsion comprising: a) fish oil triglycerides consisting of glycerol which is esterified with fatty acids wherein said fatty acids comprise EPA and DHA in an amount of at least 45% by weight of said fatty acids and the total amount of omega-3 fatty acids is at least 60% by weight

1. An oil-in-water emulsion comprising: a) fish oil triglycerides consisting of glycerol which is esterified with fatty acids wherein said fatty acids comprise EPA and DHA in an amount of at least 45% by weight of said fatty acids and the total amount of omega-3 fatty acids is at least 60% by weight of said fatty acids, andb) at least one medium chain triglyceride oil, andwherein the fish oil triglycerides are present in an amount of at least 51% by weight based on the total weight of the oil component, and the medium chain triglycerides are present in an amount of 10% to 49% by weight based on the total weight of the oil component. 2. The oil-in-water emulsion of claim 1 wherein the fish oil triglycerides are present in an amount ranging from 51% to 90% by weight based on the total weight of the oil component. 3. The oil-in-water emulsion of claim 1 wherein the oil component additionally comprises a vegetable oil. 4. The oil-in-water emulsion of claim 3 wherein the vegetable oil is present in an amount of up to 10% by weight, based on the total weight of the oil component of the oil-in-water emulsion. 5. The oil-in-water emulsion of claim 3 wherein the vegetable oil is selected from the group consisting of soybean oil and safflower oil and mixtures thereof. 6. The oil-in-water emulsion of claim 1 comprising the oil component in an amount ranging from 5% to 30% by weight, based on the total weight of the emulsion. 7. The oil-in-water emulsion of claim 1 additionally comprising at least one phospholipid. 8. The oil-in-water emulsion of claim 7 wherein the phospholipid is a phosphatidyl choline. 9. The oil-in-water emulsion of claim 7 wherein the phospholipid is present in a weight ratio of phospholipid to triglycerides ranging from 0.05 to 0.07. 10. The oil-in-water emulsion of claim 1 additionally comprising an isotonic agent present in a concentration ranging from 20 to 25 g/L. 11. The oil-in-water emulsion of claim 1 comprising a pH adjusting agent. 12. The oil-in-water emulsion of claim 1 additionally comprising an antioxidant present in a concentration of up to 1 g/L. 13. The oil-in-water emulsion of claim 1 wherein the emulsion is parenterally applicable. 14. The oil-in-water emulsion of claim 1 wherein the mean droplet diameter of the oil droplets is below 250 nm at 20° C. 15. A pharmaceutical composition comprising an oil-in-water emulsion of claim 1. 16. An emulsion comprising: an oil component and a water component, the oil component comprising: fish oil triglycerides in an amount of about 60% to about 90% based on the weight of the oil component; wherein the fish oil triglycerides comprise omega-3 fatty acids, expressed as triglycerides, in an amount of at least 60%, based on the total weight of the fatty acids of the fish oil triglycerides;wherein the fish oil triglycerides comprise a total amount of EPA and DHA, expressed as triglycerides, of at least 45%, based on the total weight of the fatty acids of the fish oil triglycerides; and,at least one medium-chain triglyceride oil, wherein a total amount of the at least one medium-chain triglyceride oil is from about 10% to about 40% based on the weight of the oil component. 17. An oil composition suitable for use as an oil component of an oil-in-water emulsion, comprising: fish oil triglycerides in an amount of about 60% to about 90% based on the weight of the composition; wherein the fish oil triglycerides comprise omega-3 fatty acids, expressed as triglycerides, in an amount of at least 60%, based on the total weight of the fatty acids of the fish oil triglycerides;wherein the fish oil triglycerides comprise a total amount of EPA and DHA, expressed as triglycerides, of at least 45%, based on the total weight of the fatty acids of the fish oil triglycerides; and,at least one medium-chain triglyceride oil, wherein a total amount of the at least one medium-chain triglyceride oil is from about 10% to about 40% based on the weight of the composition. 18. The emulsion of claim 1, wherein the emulsion is an oil-in-water emulsion, and wherein the concentration of the oil component in the emulsion is 5 g/100 mL to less than 20 g/100 mL, or the concentration of the oil component in the emulsion is greater than 20 g/100 mL to 30 g/100 mL. 19. The emulsion of claim 16, wherein the emulsion is an oil-in-water emulsion, and wherein the concentration of the oil component in the emulsion is 5 g/100 mL to less than 20 g/100 mL, or the concentration of the oil component in the emulsion is greater than 20 g/100 mL to 30 g/100 mL. 20. The emulsion of claim 16, further comprising a vegetable oil. 21. The oil composition of claim 17, further comprising a vegetable oil. 22. A method of administering the emulsion of claim 1, comprising administering parenterally a dose of the emulsion to a human body. 23. A method for treating a human having a condition selected from the group consisting of a systemic inflammatory response syndrome, a respiratory distress syndrome, a nutritional and/or dietary cause of liver disease, an iatrogenic cause of liver disease, a pathological cause of liver disease, an immune modulation, head trauma, postoperative surgical stress, a myocardial infarction, cystic fibrosis and a combination thereof, said method comprising parenterally administering to said human an effective dosage amount of the emulsion according to claim 1. 24. A method of administering the emulsion of claim 16, comprising administering parenterally a dose of the emulsion to a human body. 25. A method of administering the oil composition of claim 17, comprising administering parenterally a dose of the oil composition to a human body.