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Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A01N-001/02
  • A61L-002/24
  • A61K-041/00
  • A61L-002/00
  • A61L-002/08
  • A61L-002/10
  • C07F-011/00
  • C07F-013/00
  • C07F-015/02
  • C07F-017/00
출원번호 US-0840759 (2007-08-17)
등록번호 US-9044523 (2015-06-02)
발명자 / 주소
  • Hlavinka, Dennis J.
  • Goodrich, Raymond P.
  • Reddy, Heather
출원인 / 주소
  • TERUMO BCT, INC.
대리인 / 주소
    Pereyra, René A.
인용정보 피인용 횟수 : 0  인용 특허 : 239

초록

Methods and apparatuses are provided for reduction of pathogens in fluids containing blood products. Preferred methods include the steps of adding an effective, non-toxic amount of a photosensitizer such as riboflavin to the blood product and exposing the fluid to light having a peak wavelength.

대표청구항 ▼

1. A method for reducing pathogens in a fluid containing red blood cells comprising: reducing pathogens in the fluid while reducing the formation of methemoglobin in the fluid containing red blood cells and reducing hemolysis of the red blood cells by:adding riboflavin to the fluid at a concentratio

이 특허에 인용된 특허 (239)

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  128. Dunn Joseph E. (Rancho La Costa CA) Clark R. Wayne (Del Mar CA) Asmus John F. (LaJolla CA) Pearlman Jay S. (Rancho Palos Verde CA) Boyer Keith (Los Alamos NM) Painchaud Fraincois (Charlesbourg CA CAX, Methods for aseptic packaging of medical devices.
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  131. Dunn Joseph E. (Rancho La Costa CA) Clark R. Wayne (Del Mar CA) Asmus John F. (LaJolla CA) Pearlman Jay S. (Rancho Palos Verde CA) Boyer Keith (Los Alamos NM) Painchaud Francois (Charlesbourg CA CAX), Methods for presevation of foodstuffs.
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  136. Van Dyke Knox (Morgantown WV), Multi-faceted method to repress reproduction of latent viruses in humans and animals.
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  137. Lee Kyu H. (Bryn Mawr PA) Morris Livingston B. (Devon PA), Multicomponent fluid separation and irradiation system.
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  138. Lewis David E. (Brookings SD) Utecht Ronald E. (Volga SD) Judy Millard M. (Dallas TX) Matthews J. Lester (Dallas TX), Non-azo naphthalimide dyes.
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  140. King Martin J. (Largo FL) Troutner Vernon H. (St. Petersburg FL), Patient photopheresis treatment apparatus and method.
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  144. Bieler Barrie H. (Walnut Creek CA) Morgan David C. (Magnolia TX) Stringham Robert R. (Concord CA), Photochemical reactor and method.
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  145. Horowitz Bernard (New Rochelle NY) Valinsky Jay E. (New York NY) Geacintov Nicholas E. (New York NY) Williams Bolanle (Forest Hills NY) Rywkin Shanti B. (Brooklyn NY), Photodynamic inactivation of viruses in blood cell-containing compositions.
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  146. Horowitz Bernard (New Rochelle NY) Valinsky Jay E. (New York NY) Geacintov Nicholas E. (New York NY) Williams Bolanle (New York NY) Rywkin Shanti B. (Brooklyn NY) Nunno Henrietta (New York NY), Photodynamic inactivation of viruses in cell-containing compositions.
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  147. Leone James E., Photodynamic therapy balloon catheter with microporous membrane.
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  148. Matthews J. Lester (Dallas TX) Judy Millard M. (Dallas TX) Newman Joseph T. (Dallas TX) Sogandares-Bernal Frank (Dallas TX) Sessler Jonathan L. (Austin TX) Harriman Anthony (Austin TX) Maiya Bhaskar , Photodynamic viral deactivation with sapphyrins.
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  149. Park Sang C. (Arcadia CA) Goodrich ; Jr. Raymond P. (Pasadena CA) Yerram Nagender (S. Pasadena CA) Sowemimo-Coker Samuel O. (Arcadia CA) Platz Matthew S. (Columbus OH) Aquila Brian M. (Painesville OH, Photoinactivation of viral and bacterial blood contaminants using halogenated coumarins.
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  150. Stanco Alexei (75A Angos Street Adelaide AUX 5000) Piper James A. (Macquarie Uni. ; North Ryde Sydney ; New South Wales AUX 2113), Photoradiation method and arrangement.
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  151. Floyd Robert A. (Oklahoma City OK), Phototherapy using methylene blue.
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  152. Sekine Makoto (Yokohama JPX) Okano Haruo (Tokyo JPX) Horiike Yasuhiro (Tokyo JPX), Phototreating apparatus.
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  153. Kenney Malcolm E. (Cleveland Heights OH) Oleinick Nancy L. (University Heights OH) Rihter Boris D. (Wauwatosa WI) Li Ying-Syi (Cleveland Heights OH), Phthalocyanine photosensitizers for photodynamic therapy and methods for their use.
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  154. Murphy Scott (Ardmore PA), Plasma-based platelet concentrate preparations.
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  155. Murphy Scott (Ardmore PA), Plasma-based platelet concentrate preparations with additive.
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  156. Rock Gail A. (270 Sandridge Rd. Rockcliffe Park CAX K1L 5A2) Adams George A. (543 Broadview Ave. Ottawa CAX K2A 2L3), Plasma-free medium for platelet storage.
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  158. Shang Shaye-wen (Vernon Hills IL) Ling Michael Tung-Kiung (Vernon Hills IL) Woo Lecon (Libertyville IL) Cometa Christopher C. (Mundelein IL), Plastic formulations for platelet storage containers and the like.
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  159. Surgenor Douglas M. (Carlisle MA), Platelet concentrates.
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  160. Murphy Scott (Ardmore PA) Shimizu Tetsuo (Takamoridai JPX), Platelet storage medium containing acetate and phosphate.
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  161. Murphy Scott (Ardmore PA) Shimizu Tetsuo (Kasugai JPX), Platelet storage method in a medium containing acetate and phosphate.
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  162. Carmen Raleigh A. (Concord CA) Nelson Edward J. (San Rafael CA), Platelets concentrate with low white blood cells content.
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  165. Grimmer Johannes (Ludwigshafen DEX) Kiefer Hans (Wachenheim DEX), Preparation of riboflavin 5′-phosphate (FMN) and its sodium salt in a lactone.
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  170. Mullis Kary B. (Kensington CA) Erlich Henry A. (Oakland CA) Arnheim Norman (Woodland Hills CA) Horn Glenn T. (Emeryville CA) Saiki Randall K. (Richmond CA) Scharf Stephen J. (Berkeley CA), Process for amplifying, detecting, and/or-cloning nucleic acid sequences.
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  172. Dorner Friedrich,ATX ; Barrett Noel,ATX ; Eibl Johann,ATX, Process for disintegrating nucleic acids and preparing biological products of guaranteed quality.
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  173. Harald Mohr DE; Bernd Lambrecht DE, Process for inactivating viruses in blood and blood products.
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  174. Matsunaga Tadashi (Fuchu JPX), Process for killing cells.
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  175. Lee Eric Kin-Lam (Acton MA) Fouron Yves (Marlborough MA) Castino Franco (Sudbury MA) Zepp Charles Melvyn (Hardwick MA) Azad Abdul R. M. (Northborough MA), Process for simultaneously removing leukocytes and methylene blue from plasma.
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  179. Margolis-Nunno Henrietta ; Ben-Hur Ehud ; Horowitz Bernard, Process for the sterilization of biological compositions and the product produced thereby.
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  182. Horowitz Bernard ; Williams Bolanle ; Margolis-Nunno Henrietta ; Chin Sing N., Process for transfusing cell containing fractions sterilized with radiation and a quencher of type I and type II photod.
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  194. Blake ; II Robert C. (Elkhart IN), Purification of flavin adenine dinucleotide synthetase.
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  203. Dichtelmuller Herbert (Sulzbach/Ts. DDX) Stephan Wolfgang (Dreieich DDX), Sterilization of blood and its derivatives with vitamins.
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  205. Levy Guy (49 ; rue Croix de Regnier F-13004 Marseille FRX), Surgical treatment method and instrument.
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  207. Lin Lily (Berkeley CA) Corash Laurence (San Francisco CA), Synthetic media compositions for inactivating bacteria and viruses in blood preparations with 8-methoxypsoralen.
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  208. Lin Lily ; Corash Laurence ; Payrat Jean Marc,BEX, Synthetic media for blood components.
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  209. Holme Stein (Virginia Beach VA), Synthetic, plasma-free, transfusible platelet storage medium.
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  210. Holme Stein (Virginia Beach VA) Heaton William A. L. (Norfolk VA), Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets.
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  211. Holme Stein (Virginia Beach VA) Heaton William A. L. (Norfolk VA), Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets.
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  212. Holme Stein (Virginia Beach VA) Heaton William A. L. (Norfolk VA), Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets.
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  213. Murphy Scott (Ardmore PA), Synthetic-based platelet storage media.
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  215. D'Silva Edmund D., System to identify the status of bags that have been subjected to viral inactivation.
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  216. Brown Richard I. (Northbrook IL), Systems and methods for deriving recommended storage parameters for collected blood components.
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  219. Brown Richard I. (Northbrook IL), Systems and methods for on line collecting and resuspending cellular-rich blood products like platelet concentrate.
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  220. Sun Chong-Son ; Chapman John ; Bischof Daniel F. ; Herman Robert E., Systems and methods for removing free and entrained contaminants in plasma.
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  224. Wolf ; Jr. Ludwig (Inverness IL) Foley John T. (Wheeling IL) Bratten William R. (Lake Villa IL), Systems for eradicating contaminants using photoactive materials in fluids like blood.
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  225. Chapman John R. ; Mathias Jean M.,BEX, Systems for quantifying the illumination characteristics of vessels such as blood processing containers with respect to.
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  226. Floyd Robert A. (Oklahoma City OK) Schinazi Raymond F. (Decatur GA), Thiazine dyes used to inactivate HIV in biological fluids.
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  227. Floyd Robert A. ; Schinazi Raymond F., Thiazine dyes used to inactivate HIV in biological fluids.
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  228. Goss Jack (Clearwater FL), Three phase irradiation treatment process.
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  230. Klainer Albert S. (315 W. 70th St. New York NY 10023) Bisaccia Emil (4 Sunnybrook Rd. Basking Ridge NJ 07920), Treatment methods and vaccines for stimulating an immunological response against retroviruses.
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  232. Furumoto Horace W. (Wellesley MA) Ceccon Harry L. (Boston MA) Rizzo Antonio G. (Nashua NH), Ultra-long flashlamp-excited pulse dye laser for therapy and method therefor.
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  234. Koerner ; Jr. Theodore A. W. (Iowa City IA), Use of 2,5-anhydromannitol for control of pH during blood storage.
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  236. Swartz Mitchell R. (Malden MA), Virus inactivation applicator and the like.
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  237. Ben-Hur Ehud ; Rywkin Shanti ; Horowitz Bernard, Vitamin E and derivatives thereof prevent potassium ion leakage and other types of damage in red cells that are virus sterilized by phthalocyanines and light.
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  238. Levy Guy (Tustin CA), Water purification and sterilization process.
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  239. Graf Gregor (Basel CHX) Hlzle Gerd (Liestal CHX) Reinert Gerhard (Allschwil CHX), Water-soluble phthalocyanine compounds.
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