Dry powder inhalers with multi-facet surface deagglomeration chambers and related devices and methods
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-015/00
B05D-007/14
B65D-083/06
출원번호
US-0054808
(2009-09-25)
등록번호
US-9050427
(2015-06-09)
국제출원번호
PCT/US2009/005336
(2009-09-25)
§371/§102 date
20110309
(20110309)
국제공개번호
WO2010/039201
(2010-04-08)
발명자
/ 주소
Harris, David
Perkins, George McGee
Hainsworth, John Kenneth
Buckner, III, Charles A.
출원인 / 주소
Oriel Therapeutics, Inc.
대리인 / 주소
Myers Bigel Sibley & Sajovec
인용정보
피인용 횟수 :
12인용 특허 :
55
초록▼
Dry powder inhalers and methods are provided that facilitate deagglomeration of powdered medicament during inspiration. A dry powder inhaler includes a dry powder medicament container assembly, and an elongated dry powder delivery tube having an inlet at one end that communicates with a dose contain
Dry powder inhalers and methods are provided that facilitate deagglomeration of powdered medicament during inspiration. A dry powder inhaler includes a dry powder medicament container assembly, and an elongated dry powder delivery tube having an inlet at one end that communicates with a dose container, and an outlet or inhalation port that extends from the inhaler housing at an opposite end. The delivery tube includes one or more apertures adjacent the inlet that cause cyclonic or turbulent airflow through the delivery tube. The inner surface of the delivery tube has a polygonal configuration and the cyclonic air stream bounces off the polygonal inner surface numerous times as the air stream flows through the delivery tube. Another dry powder inhaler includes a deagglomeration chamber with a polygonal inner surface. An air stream containing dry powder medicament is directed into the deagglomeration chamber and impacts the polygonal inner surface numerous times.
대표청구항▼
1. A dry powder inhaler, comprising: a dry powder container assembly; andan elongated dry powder delivery tube having a first end with an inlet that has an orientation defined by a first central longitudinal axis and that is configured to communicate with a dose container in the container assembly,
1. A dry powder inhaler, comprising: a dry powder container assembly; andan elongated dry powder delivery tube having a first end with an inlet that has an orientation defined by a first central longitudinal axis and that is configured to communicate with a dose container in the container assembly, a second end that is opposite the first end and that has an outlet that has an orientation defined by a second central longitudinal axis, and a tube wall having a portion with substantially cylindrical outer surface, and wherein at least a longitudinally extending portion of an inner surface of the tube wall has a substantially polygonal cross-section configuration, wherein a plurality of circumferentially spaced-apart air inlet apertures are formed through the tube wall portion adjacent the delivery tube inlet to provide airflow into the tube, and wherein the plurality of air inlet apertures are oriented such that airflow therethrough enters the tube in a direction that is substantially transverse to a longitudinal axis of the tube;wherein dry powder is drawn through the tube from a dose container in the container assembly upon user inhalation through the tube outlet, and wherein the orientation of the first central longitudinal axis relative to the second central longitudinal axis defines an obtuse angle therebetween. 2. The inhaler of claim 1, wherein the at least one air inlet aperture is oriented to cause airflow through the tube to impact the portion of the tube wall inner surface having the polygonal configuration so as to facilitate deagglomeration of dry powder entrained therein. 3. The inhaler of claim 1, wherein the tube outlet comprises an inhalation port. 4. The inhaler of claim 1, wherein a cross-sectional area of the delivery tube inlet is less than or equal to a cross-sectional area of the delivery tube outlet. 5. The inhaler of claim 1, wherein the polygonal cross-section is hexagonal. 6. The inhaler of claim 1, wherein the portion of the tube wall inner surface having the polygonal configuration comprises a plurality of elongated planar surfaces oriented substantially parallel with a longitudinal axis of the tube, and wherein an angle between adjacent elongated planar surfaces is greater than or equal to about one-hundred five degrees (105°). 7. The inhaler of claim 1, wherein the portion of the tube wall inner surface having the polygonal configuration comprises a plurality of elongated planar surfaces oriented substantially parallel with a longitudinal axis of the tube, and wherein an angle between adjacent elongated planar surfaces is greater than or equal to about one-hundred twenty degrees (120°). 8. The inhaler of claim 1, wherein the portion of the tube wall inner surface having the polygonal configuration comprises a plurality of elongated planar surfaces oriented substantially parallel with a longitudinal axis of the tube, and wherein an angle between adjacent elongated planar surfaces is greater than or equal to about one-hundred thirty-five degrees (135°). 9. The inhaler of claim 1, wherein the portion of the tube wall inner surface having the polygonal configuration extends greater than ten millimeters (10 mm). 10. A dry powder inhaler, comprising: a dry powder container assembly; anda dry powder delivery tube, wherein the dry powder delivery tube comprises: a first conduit having an inlet configured to communicate with a dose container in the container assembly, and an outlet, wherein the first conduit has an arcuate configuration; anda second conduit having a deagglomeration chamber and an outlet, wherein the deagglomeration chamber has a polygonal cross-section, and wherein the first conduit outlet is in communication with the deagglomeration chamber such that airflow entering the deagglomeration chamber from the first conduit outlet is directed along a direction that extends away from the second conduit outlet and defines an obtuse angle relative to an axial direction of the second conduit outlet;wherein dry powder is drawn from a dose container in the dry powder container assembly and through the first and second conduits upon user inhalation through the second conduit outlet. 11. The inhaler of claim 10, wherein the first conduit outlet defines an axial direction that is substantially transverse to an axial direction of the second conduit. 12. The inhaler of claim 10, wherein the first conduit outlet is in communication with the second conduit deagglomeration chamber such that airflow into the deagglomeration chamber impacts the polygonal inner surface so as to facilitate deagglomeration of dry powder entrained therein. 13. The inhaler of claim 10, wherein the second conduit outlet has a substantially straight configuration. 14. The inhaler of claim 10, wherein the first conduit has an arcuate configuration such that large dry powder particles from the first conduit inlet impact an inner surface of the first conduit and are reflected directly into the second conduit. 15. A method of deagglomerating dry powder in a dry powder inhaler, comprising: entraining dry powder within an air stream; andimpacting the air stream against a polygonal inner surface of a conduit to thereby facilitate deagglomeration of the dry powder, wherein the conduit includes an outlet, and wherein the air stream enters the conduit in a direction that extends away from the conduit outlet and defines an obtuse angle relative to an axial direction of the conduit outlet;wherein the polygonal inner surface comprises a plurality of elongated planar surfaces oriented substantially parallel with a longitudinal axis of the conduit, and wherein an angle between adjacent elongated planar surfaces is greater than or equal to about one-hundred five degrees (105°), greater than or equal to about one-hundred twenty degrees (120°), or greater than or equal to about one-hundred thirty-five degrees (135°).
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