초록

The present invention relates to synergistic compositions for protection against oxidative damage, consisting essentially of antacids in conjunction with antioxidants. The invention further relates to method for preventing oxidative damage using the compositions of the invention.

대표청구항 ▼

1. A composition for potentiating antioxidative activities, consisting essentially of: (a) at least one classical antacid in a dose capable of neutralizing 100 ml of 0.009 M HCl, such that the composition is capable of elevating the pH in a stomach by at least one pH unit, said elevating the pH bein

1. A composition for potentiating antioxidative activities, consisting essentially of: (a) at least one classical antacid in a dose capable of neutralizing 100 ml of 0.009 M HCl, such that the composition is capable of elevating the pH in a stomach by at least one pH unit, said elevating the pH being from a pH of 2 to a pH of at least 3;(b) at least one antioxidant which is a polyphenol, wherein the relative amount of the at least one antioxidant in the composition is from 30 to 95% w/w of the composition; and, optionally,(c) at least one pharmaceutically acceptable carrier,said at least one classical antacid being selected from a group consisting of: sodium bicarbonate, potassium hydroxide, aluminum carbonate, aluminum hydroxide, aluminum phosphate, aluminum hydroxy carbonate, dihydroxy aluminum sodium carbonate, aluminum magnesium glycinate, dihydroxy aluminum aminoacetate, dihydroxyaluminum aminoacetic acid, calcium carbonate, calcium phosphate, hydrated magnesium aluminate activated sulfate, magnesium aluminate, magnesium aluminosilicates, magnesium carbonate, magnesium glycinate, magnesium hydroxide, magnesium oxide and magnesium trisilicate. 2. The composition according to claim 1, wherein the composition is capable of decreasing generation of free radicals and peroxides in the stomach or esophagus more than the same dose of antioxidant in an absence of antacid. 3. The composition according to claim 2, wherein the composition has an ability to decrease at least two fold concentration of free radicals and peroxides in the stomach or esophagus. 4. The composition according to claim 1, comprising at least two distinct antioxidants. 5. The composition according to claim 1, comprising at least two distinct antacids from said at least one classical antacid. 6. The composition according to claim 1, wherein the antioxidant is a polyphenol selected from a group consisting of: anthocyanins; flavonols; flavanols; flavanones; flavanonols; hydrolyzed tannins; proanthocyanidins; lignine; and stilbenes. 7. The composition according to claim 1, wherein the relative amount of the at least one antioxidant in the composition is from 30 to 65% w/w of the composition. 8. The composition according to claim 7, wherein the relative amount of the at least one antioxidant in the composition is from 40 to 60% w/w of the total antacid and antioxidant weight. 9. The composition according to claim 1, wherein the composition is provided in any physical form suitable for oral administration. 10. The composition according to claim 9, the composition having a physical form selected from a group consisting of: tablet, compressed tablet, spheroid, capsule, powder and suspension and liquid. 11. The composition according to claim 10, further comprising at least one ingredient selected from a group consisting of: filler, disintegrant, anticaking agent, film coating, coating solution, binder, stabilizer for solution or for solid forms, entericoating polymer, sweetening agent, glidant, flavor, color, lubricant and plasticizer. 12. The composition according to claim 1, wherein the antioxidant is a polyphenol selected from a group consisting of: chalcones; phenolic acids; anthocyanins; flavonols; flavanols; flavanones; flavanonols; hydrolyzed tannins; proanthocyanidins; phenolamines; lignans; lignine; betalains; stilbenes; cyclic diterpenes; monoterpenes and sesquiterpenes; sesamolin and isoflavones. 13. The composition according to claim 1, wherein said elevating the pH comprises elevating the pH to a pH of up to 9. 14. A composition for potentiating antioxidative activities, consisting essentially of: (a) at least one classical antacid in a dose capable of neutralizing 100 ml of 0.009 M HCl, such that the composition is capable of elevating the pH in a stomach by at least one pH unit, said elevating the pH being from a pH of 2 to a pH of at least 3;(b) at least one antioxidant which is a polyphenol, wherein the relative amount of the at least one antioxidant in the composition is from 30 to 95% w/w of the composition; and, optionally,(c) at least one pharmaceutically acceptable carrier,said at least one classical antacid being selected from a group consisting of: sodium bicarbonate, potassium hydroxide, calcium carbonate, calcium phosphate, magnesium carbonate, magnesium glycinate, magnesium hydroxide, magnesium oxide and magnesium trisilicate.