Compositions and methods for therapeutic delivery with frozen particles
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/00
A61K-009/16
A61K-009/08
A61K-031/00
A61K-051/12
A61K-033/00
A61K-009/19
A61K-031/337
A61K-031/70
A61K-031/7088
A61K-041/00
A61K-045/06
A61K-039/00
출원번호
US-0290671
(2008-10-31)
등록번호
US-9072688
(2015-07-07)
발명자
/ 주소
Boyden, Edward S.
Hyde, Roderick A.
Leuthardt, Eric C.
Myhrvold, Nathan P.
Sweeney, Elizabeth A.
Wood, Jr., Lowell L.
출원인 / 주소
The Invention Science Fund I, LLC
인용정보
피인용 횟수 :
1인용 특허 :
173
초록▼
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particula
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
대표청구항▼
1. A therapeutic composition, comprising: one or more frozen hydrogen oxide particles less than 200 micrometers in size and coated with a specific cell receptor; the one or more frozen hydrogen oxide particles each further defining at least two cavities, the first cavity containing at least one anti
1. A therapeutic composition, comprising: one or more frozen hydrogen oxide particles less than 200 micrometers in size and coated with a specific cell receptor; the one or more frozen hydrogen oxide particles each further defining at least two cavities, the first cavity containing at least one anti-tumor agent, including at least one of an alkylating agent, antimetabolite, anthracycline, plant alkaloid, topoisomerase inhibitor, monoclonal antibody, or tyrosine kinase inhibitor;and the second cavity containing one or more of a cytokine, chemokine, anti-angiogenic factor, anti-inflammatory agent, vaccine, hormone, or radioactive agent. 2. The therapeutic composition of claim 1, wherein the one or more frozen hydrogen oxide particles are in phase ice Ic. 3. The therapeutic composition of claim 1, wherein the composition has a density greater than approximately 0.92 g/cm3. 4. The therapeutic composition of claim 1, wherein the one or more frozen hydrogen oxide particles exist at about −20° C., about −30° C., about −40° C., about −50° C., about −60° C., about −70° C., about −75° C., about −80° C., about −85° C., about −90° C., about −95° C., about −100° C., about −120° C., about −150° C., about −180° C., about −200° C., about −220° C., about −250° C., or any value less than or therebetween. 5. The therapeutic composition of claim 1, wherein the at least one major dimension includes at least one of the radius, diameter, length, width, height, or perimeter. 6. The therapeutic composition of claim 1, wherein the at least one plant alkaloid includes paclitaxel. 7. The therapeutic composition of claim 1, further including one or more of nitrogen, oxygen, air, helium, neon, argon, xenon, chlorine, bromine, or carbon dioxide, polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer's solution, lactated Ringer's solution, Hartmann's solution, acetated Ringer's solution, phosphate buffered solution, TRIS-buffered saline solution, Hank's balanced salt solution, Earle's balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, or diethyl ether. 8. The therapeutic composition of claim 1, wherein the one or more frozen hydrogen oxide particles approximate the shape of at least one of a sphere, bullet, flechette, cone, needle, arrow, spear, diamond, pyramid, cylinder, minie ball, shuttlecock, spiral, bell, pear, crystal, cube, spheroid, tetrahedron, or crescent. 9. The therapeutic composition of claim 1, wherein the one or more frozen particles include a plurality of frozen particles that are approximately uniform in size, shape, weight, or density. 10. The therapeutic composition of claim 1, wherein the therapeutic composition includes one or more of a suspension, mixture, solution, sol, clathrate, colloid, emulsion, microemulsion, aerosol, ointment, capsule, powder, tablet, suppository, cream, device, paste, liniment, lotion, ampule, elixir, spray, suspension, syrup, tincture, detection material, polymer, biopolymer, buffer, adjuvant, diluent, lubricant, disintegration agent, suspending agent, solvent, light-emitting agent, colorimetric agent, glidant, anti-adherent, anti-static agent, surfactant, plasticizer, emulsifying agent, flavor, gum, sweetener, coating, binder, filler, compression aid, encapsulation aid, preservative, granulation agent, spheronization agent, stabilizer, adhesive, pigment, sorbent, nanoparticle, or gel. 11. The therapeutic composition of claim 1, further including one or more reinforcement agents. 12. The therapeutic composition of claim 11, wherein the one or more reinforcement agents include at least one of a natural, artificial, or synthetic agent. 13. The therapeutic composition of claim 11, wherein the one or more reinforcement agents include at least one of a plate, fiber, or spheroid. 14. The therapeutic composition of claim 11, wherein the one or more reinforcement agents include one or more of polyaramid, vinylester matrix, metal, ceramic, fiberglass, cellulose, broad carbide, aromatic polyamide, nylon, silk, rayon, acetate, modacrylic, olefin, acrylic, polyester, aromatic polyester, poly-lactic acid, vinyon, saran, spandex, vinalon, aromatic nylon, vinylidene chloride, modal, polybenzimidazole, sulfur, lyocell, orlon, zylon, high-performance polyethylene, polypyridobenzimidazole, vectran, acrylonitrile rubber, glass, copper, iron, steel, sodium, potassium, calcium, zinc, manganese, carbon, magnesium, silicon, silica, plant matter, animal matter, or mineral matter. 15. The therapeutic composition of claim 11, wherein the one or more reinforcement agents are located at least on the surface or beneath the surface of the particle. 16. The therapeutic composition of claim 11, wherein the one or more reinforcement agents are located within the particle. 17. The therapeutic composition of claim 1, further including at least one of a polymer, biopolymer, nanoparticle, or detection material. 18. The therapeutic composition of claim 17, wherein the detection material includes at least one electronic identification device. 19. The therapeutic composition of claim 18, wherein the at least one electronic identification device includes at least one radio frequency identification device. 20. The therapeutic composition of claim 17, wherein the detection material includes at least one radioactive element. 21. The therapeutic composition of claim 20, wherein the at least one radioactive element includes one or more of 32P, 35S, 13C, 131I, 191Ir, 192Ir, 193Ir, 201Tl, or 3H. 22. The therapeutic composition of claim 17, wherein the detection material includes at least one colorimetric substance. 23. The therapeutic composition of claim 22, wherein the at least one colorimetric substance includes one or more of an inorganic, organic, biological, natural, artificial, or synthetic substance. 24. The therapeutic composition of claim 22, wherein the at least one colorimetric substance includes one or more of a dye, pigment, or light-emitting substance. 25. The therapeutic composition of claim 24, wherein the light-emitting substance includes at least one of a fluorescent substance, phosphorescent substance, or quantum dot. 26. The therapeutic composition of claim 22, wherein the at least one colorimetric substance is biocompatible. 27. The therapeutic composition of claim 17, wherein the detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic contrast agent, or other magnetic particle. 28. The therapeutic composition of claim 1, formulated to be administered by one or more of topical delivery, oral delivery, enteral delivery, mucosal delivery, percutaneous delivery, or parenteral delivery. 29. The therapeutic composition of claim 28, wherein parenteral delivery includes at least one of intravenous delivery, intra-arterial delivery, intracardiac delivery, subcutaneous delivery, intraperitoneal delivery, or intramuscular delivery. 30. The therapeutic composition of claim 1, formulated to be administered by high velocity impact. 31. The therapeutic composition of claim 1, formulated to be administered by one or more devices. 32. The therapeutic composition of claim 1, further including at least one pharmaceutically-acceptable carrier or excipient. 33. The therapeutic composition of claim 1, further including one or more explosive materials.
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Topalian Harry H. (Dover DE) Wyss Clement R. (Lewes DE) Kenyon Ralph E. (Dover DE) Dec Anthony F. (Dover DE), Frozen aerated ready-to-eat gelatin composition.
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Brinegar Chris (587 Locksley Rd. Boulder Creek CA 95006) Gilmore James (6385 Camino Verde Dr. San Jose CA 95119) Johnson Michael (6385 Camino Verde Dr. San Jose CA 95119) Walker Nigel (5385 Broadway , Ice-mediated introduction of substances into biological material.
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Weaver, James C.; Anderson, R. Rox; Herndon, Terry O; Gowrishankar, T. R.; Gift, Elizabeth A.; Gonzalez, Salvador, Localized molecular and ionic transport to and from tissues.
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Power Wendy ; Reed Michael A. ; Frustaci Dominick J. ; Larocque Gerald ; Marchetti Brenda, Method and apparatus for determining quantity of liquid in a container and/or lack of motion thereof.
Westergaard Knud E. (Rolighedsvej 16 9560 Hadsund DKX), Method and apparatus for particle blasting using particles of a material that changes its state.
Frohlich, Hans; Gebhardt, Sabine; Trampusch, Berthold, Method and device for generating a two-phase gas-particle jet, in particular containing CO2 dry ice particles.
Cates Michael C. (Solana Beach CA) Hamm Richard R. (San Diego CA) Lewis Michael W. (Wichita KS) Schmitz Wayne N. (St. Louis MO), Method and system for removing a coating from a substrate using radiant energy and a particle stream.
Sanford John C. (Geneva NY) Wolf Edward D. (Ithaca NY) Allen Nelson K. (Newfield NY), Method for transporting substances into living cells and tissues and apparatus therefor.
Bellhouse Brian J. (Islip GB2) Sarphie David F. (Witney GB2) Greenford John C. (Abingdon GB2), Method of delivering powder transdermally with needless injector.
Costantino Henry R. ; Jaworowicz Warren E. ; Tracy Mark A. ; Beganski Christopher P., Method of producing sub-micron particles of biologically active agents and uses thereof.
Cummins Thomas J. (Rochester NY) Ekeze Tobias D. (Rochester NY), Methods of extracting nucleic acids and PCR amplification without using a proteolytic enzyme.
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Shih, Hong; Leonte, Oana M.; Daugherty, John E.; Huang, Tuochuan; Goldspring, Gregory J.; May, Michael C., On-line chamber cleaning using dry ice blasting.
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Dean ; Jr. Robert C. (Norwich VT) Silver Frederick H. (Long Valley NJ) Berg Richard A. (Lambertville NJ) Phillips Philip G. (Norwich VT) Runstadler ; Jr. Peter W. (Hanover NH), Weighted collagen microsponge for immobilizing bioactive material.
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