[특허]Medical implant including a 3D mesh of oxidized cellulose and a collagen sponge

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61F-002/02 A61L-027/24 A61L-027/20 A61L-027/56
출원번호	US-0125595 (2009-11-06)
등록번호	US-9119898 (2015-09-01)
국제출원번호	PCT/IB2009/007742 (2009-11-06)
§371/§102 date	20110715 (20110715)
국제공개번호	WO2010/052587 (2010-05-14)
발명자 / 주소	Bayon, Yves Ladet, Sébastien Lefranc, Olivier Gravagna, Philippe
출원인 / 주소	Sofradim Production
인용정보	피인용 횟수 : 44 인용 특허 : 2

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The present invention relates to A bioresorbable implant comprising: a bioresorbable porous layer including a biopolymer foam and defining first pores, a bioresorbable porous three-dimensional mesh made from a microbial cellulose and defining second pores, wherein the bioresorbable porous layer is d

The present invention relates to A bioresorbable implant comprising: a bioresorbable porous layer including a biopolymer foam and defining first pores, a bioresorbable porous three-dimensional mesh made from a microbial cellulose and defining second pores, wherein the bioresorbable porous layer is disposed in the bioresorbable porous three-dimensional mesh. The invention also relates to a method of making a bioresorbable implant.

대표청구항 ▼

1. A bioresorbable implant comprising: a bioresorbable porous layer including a biopolymer foam defining first pores, and a three-dimensional density from about 30 mg collagen/cm3 to about 150 mg collagen cm3,a bioresorbable porous three-dimensional mesh made from a microbial cellulose having a thic

1. A bioresorbable implant comprising: a bioresorbable porous layer including a biopolymer foam defining first pores, and a three-dimensional density from about 30 mg collagen/cm3 to about 150 mg collagen cm3,a bioresorbable porous three-dimensional mesh made from a microbial cellulose having a thickness of about 0.1 cm to about 3 cm, and defining second pores from about 0.5 mm to about 5 mm, wherein the bioresorbable porous layer is disposed in the bioresorbable porous three-dimensional mesh, anda non-porous film applied to the bioresorbable porous three-dimensional mesh including the bioresorbable porous layer. 2. The bioresorbable implant of claim 1, wherein the first and second pores are at least partially interconnected with one another. 3. The bioresorbable implant of claim 1, wherein the microbial cellulose is derived from Acetobacter xylinum as wet pellicles or films. 4. The bioresorbable implant of claim 1, wherein the microbial cellulose is oxidized. 5. The bioresorbable implant of claim 1, wherein the biopolymer foam comprises pores having a size of from about 10 μm to about 500 μm. 6. The bioresorbable implant of claim 1, wherein the biopolymer foam is from about 0.2 to about 1.5 cm thick. 7. The bioresorbable implant of claim 1, further comprising a bioactive agent. 8. The bioresorbable implant of claim 1, wherein the microbial cellulose mesh displays a minimal elongation at break in at least one direction of about 50 N. 9. The bioresorbable implant of claim 1, wherein the microbial cellulose has a thickness of about 0.2 cm to about 1 cm. 10. The bioresorbable implant of claim 1, wherein the non-porous film is positioned on a first side of the implant to reduce postsurgical adhesions and the porous layer is positioned on a second side opposite the first side of the implant to allow for cell colonization. 11. The bioresorbable implant of claim 1, wherein the non-porous layer is from about 30 μms to about 75 μms thick and the porous layer is from about 0.3 cms to about 1.2 cms thick. 12. A method of making a bioresorbable implant, comprising: adding an aqueous acid solution or suspension of collagen to a bioresorbable porous three-dimensional mesh made from a microbial cellulose having a thickness of about 0.1 cm to about 3 cm, and defining second pores from about 0.5 mm to about 5 mm,lyophilizing the solution to create a bioresorbable foam layer in the bioresorbable porous three-dimensional mesh, wherein the bioresorbable foam layer includes a three-dimensional density from about 30 mg collagen/cm3 to about 150 mg collagen/cm3, andapplying a non porous layer to the bioresorbable porous three-dimensional mesh that has been filled with the bioresorbable foam layer. 13. The method of claim 12, wherein the biopolymer foam layer is cross-linked. 14. The method of claim 12, wherein the non porous layer comprises a collagenic constituent. 15. The method of claim 12, wherein the microbial cellulose has a thickness of about 0.2 cm to about 1 cm. 16. The method of claim 12, wherein the non-porous film is positioned on a first side of the implant to reduce postsurgical adhesions and the porous layer is positioned on a second side opposite the first side of the implant to allow for cell colonization. 17. The method of claim 12, wherein the non-porous layer is from about 30 μmsto about 75 μms thick and the porous layer is from about 0.3 cms to about 1.2 cms thick.

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이 특허에 인용된 특허 (2) 인용/피인용 타임라인 분석

Fran.cedilla.ois Regis Ory FR; Michel Therin FR; Philippe Gravagna FR; Jean-Louis Tayot FR, Composite prosthesis for preventing post-surgical adhesions and method for obtaining same.
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Bell Eugene ; Fofonoff Timothy W., Methods for preparing biopolymer foams.
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[미국특허] Medical implant including a 3D mesh of oxidized cellulose and a collagen sponge 원문보기

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