[특허]Method of treatment of renal dysfunctions with chimeric natriuretic peptides

[미국특허] Method of treatment of renal dysfunctions with chimeric natriuretic peptides 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-038/22 A61K-038/16 A61K-038/12 C07K-014/58 A61K-038/00
출원번호	US-0683291 (2012-11-21)
등록번호	US-9132166 (2015-09-15)
발명자 / 주소	Simari, Robert D. Pan, Shuchong Burnett, Jr., John C. Chen, Horng H.
출원인 / 주소	Mayo Foundation for Medical Education and Research
대리인 / 주소	Fish & Ricahrdson P.C.
인용정보	피인용 횟수 : 1 인용 특허 : 37

초록 ▼

This document provides diuretic and natriuretic polypeptides. For example, this document provides polypeptides having diuretic and/or natriuretic activities. In some cases, a polypeptide provided herein can have diuretic and natriuretic activities, while lacking the ability to lower blood pressure.

대표청구항 ▼

1. A method for treating a mammal having a renal dysfunction, wherein said method comprises administering to said mammal a polypeptide between 37 and 47 amino acid residues in length, wherein said polypeptide comprises an amino acid sequence that aligns to the sequence set forth in SEQ ID NO:1 with five, four, three, two, or one amino acid addition(s), deletion(s), substitution(s), or combinations thereof, and wherein said polypeptide is administered in an amount effective to reduce the severity of a symptom of said renal dysfunction. 2. The method of claim 1, wherein said mammal is a human. 3. The method of claim 1, wherein said renal dysfunction comprises renal failure. 4. The method of claim 1, wherein said renal dysfunction comprises renal failure accompanied with congestive heart failure. 5. The method of claim 1, wherein said polypeptide is between 40 and 44 amino acid residues in length and comprises an amino acid sequence that aligns to the sequence set forth in SEQ ID NO:1 with one or two amino acid additions, deletions, substitutions, or combinations thereof. 6. The method of claim 1, wherein said symptom comprises an abnormal serum creatinine level, urine flow, renin level, glomerular filtration rate, urinary cGMP excretion rate, urinary ANP excretion rate, urinary BNP excretion rate, cardiac output, systemic vascular resistance, or aldosterone level.

이 특허에 인용된 특허 (37) 인용/피인용 타임라인 분석

Ronald P. Mischak ; Garrett A. Lim ; Jan Marian Scardina, Assay and reagents for quantifying hBNp.
상세보기
Lewicki John A. (Sunnyvale CA) Scarborough ; Jr. Robert M. (Hayward CA), Atrial Natriuretic/vasodilator peptide compounds.
상세보기
Needleman Philip (Olivette MO), Atrial Peptides.
상세보기
Chan, Lily; Chung, Maxey Ching Ming; Lim, Renee Lay Hong, Bacterial-derived molecules and therapeutic and diagnostic uses therefor.
상세보기
Seilhamer,J. Jeffrey; Lewicki,John A.; Scarborough,Robert M.; Porter,J. Gordon, Brain natriuretic peptide.
상세보기
Cojocaru,Gad S.; Diber,Alexander; Novik,Amit; Pollock,Sarah; Levine,Zurit; Cohen,Yossi; Ayalon Soffer,Michal, Brain natriuretic peptide spliced variant.
상세보기
LaMotte ; III George B. (Larkspur CA), Bridge immunoassay.
상세보기
Tanaka Shoji (4-24-204 ; Nishiokamoto 6-chome Hyogo JPX) Minamitake Yoshiharu (4-24-204 ; Nishiokamoto 6-chome Kanagawa JPX) Kitajima Yasuo (4-24-204 ; Nishiokamoto 6-chome Osaka JPX) Furuya Mayumi (, CNP analog peptides and their use.
상세보기
Burnett, Jr., John C.; Lisy, Ondrej, Chimeric natriuretic peptides.
상세보기
Felgner Philip L. (Rancho Santa Fe CA) Wolff Jon A. (Madison WI) Rhodes Gary H. (Leucadia CA) Malone Robert W. (Chicago IL) Carson Dennis A. (Del Mar CA), Delivery of exogenous DNA sequences in a mammal.
상세보기
Simari, Robert D.; Pan, Shuchong; Burnett, Jr., John C.; Chen, Horng H., Diuretic and natriuretic polypeptides lacking the blood pressure lowering property.
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Heller Michael J. (Poway CA) Jablonski Edward J. (San Diego CA), Fluorescent stokes shift probes for polynucleotide hybridization.
상세보기
Mischak Ronald P. ; Lim Garrett A. ; Scardina Jan Marian, Human brain natriuretic peptides.
상세보기
Heller Michael J. (Encinitas CA), Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to donor energy transfe.
상세보기
Heller Michael J., Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transf.
상세보기
Heller Michael J., Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system.
상세보기
Asada, Hidehisa; Shimizu, Hiroyuki; Endou, Kazuaki, Immunoassay method for BNP.
상세보기
Seilhamer, J. Jeffrey; Lewicki, John; Scarborough, Robert M.; Porter, J. Gordon, Immunoassays for human brain natriuretic peptide.
상세보기
Felgner Philip L. (Rancho Santa Fe CA) Wolff Jon A. (Madison WI) Rhodes Gary H. (Leucadia CA) Malone Robert W. (Chicago IL) Carson Dennis A. (Del Mar CA), Induction of a protective immune response in a mammal by injecting a DNA sequence.
상세보기
Pan, Shuchong; Simari, Robert D., Isoforms of brain natriuretic peptide.
상세보기
Simari, Robert D.; Pan, Shuchong; Burnett, Jr., John C.; Chen, Horng H.; Potter, Lincoln R., Natriuretic peptide receptor-C agonists.
상세보기
Rubenfield, Marc J.; Nolling, Jork; Deloughery, Craig; Bush, David, Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics.
상세보기
Kovalic,David K.; Andersen,Scott E.; Byrum,Joseph R.; Conner,Timothy W.; Masucci,James D.; Zhou,Yihua, Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement.
상세보기
Seilhamer, J. Jeffrey; Lewicki, John; Scarborough, Robert M.; Porter, J. Gordon, Pharmaceutical compositions and methods using natriuretic peptides.
상세보기
Venter, J. Craig; Zhang, Jinghui N.; Liu, Xiangjun; Rowe, William; Cravchik, Anibal; Kalush, Francis; Naik, Ashwinikumar; Subramanian, Gangadharan; Woodage, Trevor, Polymorphisms in known genes associated with human disease, methods of detection and uses thereof.
상세보기
Bridon, Dominique P.; Ezrin, Alan M.; Milner, Peter G.; Holmes, Darren L.; Thibaudeau, Karen, Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components.
상세보기
Bridon, Dominique P.; Ezrin, Alan M.; Milner, Peter G.; Holmes, Darren L.; Thibaudeau, Karen, Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components.
상세보기
Maggio Edward T. (Redwood City CA) Wife Richard L. (Sittingbourne CA GB2) Ullman Edwin F. (Atherton CA), Reagents and method employing channeling.
상세보기
Lowe David (Brisbane CA) Cunningham Brian C. (Piedmont CA) Oare David (Belmont CA) McDowell Robert S. (San Francisco CA) Burnier John (Pacifica CA), Receptor specific atrial natriuretic peptides.
상세보기
Lowe David G. ; Cunningham Brian C. ; Oare David ; McDowell Robert S. ; Burnier John P., Receptor specific atrial natriuretic peptides.
상세보기
Seilhamer J. Jeffrey ; Lewicki John ; Scarborough Robert M. ; Porter J. Gordon, Recombinant canine brain natriuretic peptide.
상세보기
Seilhamer J. Jeffrey (Milpitas CA) Lewicki John (San Jose CA) Scarborough Robert M. (Hayward CA) Porter J. Gordon (Newark CA), Recombinant techniques for production of human brain natriuretic peptide.
상세보기
Seilhamer Jeffrey J. (Milpitas CA) Lewicki John A. (Los Gatos CA) Scarborough Robert M. (Belmont CA) Porter J. Gordon (Newark CA), Recombinant techniques for production of novel natriuretic and vasodilator peptides.
상세보기
Piasio ; Roger N. ; Ryan ; James W. ; Woiszwillo ; James E., Reverse sandwich immunoassay.
상세보기
Seilhamer, J. Jeffrey; Lewicki, John; Scarborough, Robert M.; Porter, J. Gordon, Subcutaneous administration of natriuretic peptide.
상세보기
Miles Laughton E. M. (Stanford CA), Universal reagent 2-site immunoradiometric assay using labelled anti (IgG).
상세보기
Wei Chi-Ming (Rochester MN) Burnett John C. (Rochester MN), Vasonatrin peptide and analogs thereof.
상세보기

이 특허를 인용한 특허 (1) 인용/피인용 타임라인 분석

Simari, Robert D.; Pan, Shuchong; Burnett, Jr., John C.; Chen, Horng H., Methods of treatment of heart dysfunctions using diuretic and natriuretic polypeptides.
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A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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[미국특허] Method of treatment of renal dysfunctions with chimeric natriuretic peptides 원문보기