Reaction vessel comprising conductive layer and inner non-metallic layer
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C12P-019/34
C12M-001/00
B01L-007/00
B01L-003/00
G01N-021/03
출원번호
US-0671272
(2008-08-01)
등록번호
US-9138748
(2015-09-22)
우선권정보
GB-0715170.7 (2007-08-03)
국제출원번호
PCT/GB2008/002631
(2008-08-01)
§371/§102 date
20100729
(20100729)
국제공개번호
WO2009/019454
(2009-02-12)
발명자
/ 주소
Lee, Martin Alan
Squirrell, David James
Jones, Ross Peter
Williamson, Roger James
Gregory, George Richard
Gutsell, Graham
출원인 / 주소
ENIGMA DIAGNOSTICS LIMITED
인용정보
피인용 횟수 :
0인용 특허 :
33
초록▼
A reaction vessel for conducting a chemical or biochemical reaction, such as a polymerase chain reaction wherein at least one wall of said vessel comprises a metallic layer and an inner non-metallic layer. Reaction systems comprising combinations of vessels of the invention and apparatus for heating
A reaction vessel for conducting a chemical or biochemical reaction, such as a polymerase chain reaction wherein at least one wall of said vessel comprises a metallic layer and an inner non-metallic layer. Reaction systems comprising combinations of vessels of the invention and apparatus for heating them, as well as particular reactions vessels are also described and claimed.
대표청구항▼
1. A reaction vessel for conducting a chemical or biochemical reaction, said reaction vessel comprising a capillary vessel or a flattened capillary vessel; and at least one wall of said reaction vessel comprising a thermally conducting layer, an inner non-metallic layer and an integral resistive hea
1. A reaction vessel for conducting a chemical or biochemical reaction, said reaction vessel comprising a capillary vessel or a flattened capillary vessel; and at least one wall of said reaction vessel comprising a thermally conducting layer, an inner non-metallic layer and an integral resistive heating element which is arranged outside the thermally conducting layer; the thermally conducting layer comprising a metallic layer with a passivated outer surface, and wherein the integral resistive heating element is electrically insulated from the metallic layer by the passivated outer surface of the metallic layer. 2. The reaction vessel according to claim 1, wherein said reaction vessel comprises long walls, wherein the one wall forms at least one of the long walls. 3. The reaction vessel according to claim 2 wherein a base of the capillary vessel or the flattened capillary vessel is of a transparent material. 4. The reaction vessel according to claim 3 wherein a seal is provided between the transparent material and the capillary vessel or the flattened capillary vessel. 5. The reaction vessel according to claim 1 wherein an entire side wall of the reaction vessel comprises a metallic layer and an inner non-metallic layer. 6. The reaction vessel according to claim 1 wherein the metallic layer comprises aluminum. 7. The reaction vessel according to claim 1 wherein the inner non-metallic layer is a polymeric material, glass, a passivated metal or a combination of these. 8. The reaction vessel according to claim 7 wherein the polymeric layer comprises a compound of formula (I) where R is a substituent group selected from R1, OR1, SR1, OC(O)R1, C(O)OR1, hydroxyl, halogen, nitro, nitrile, amine, carboxy or mercapto and where R1 is any hydrocarbon group and where R1 may be optionally substituted by one or more groups selected from hydroxyl, halogen, nitro, nitrile, amine or mercapto; and where m is 0 or an integer of from 1 to 3; and n is sufficient for the compound to be a polymer. 9. The reaction vessel according to claim 1 which is adapted for use in a block heater. 10. The reaction vessel according to claim 1 wherein the integral resistive heating element comprises electrically conducting polymer. 11. The reaction vessel according to claim 10 which further comprises a barbed electrical contact which pierces a surface of the electrically conducting polymer and is connectable to a control system which allows controllable heating of the electrically conducting polymer. 12. The reaction vessel according to claim 10 wherein a radial thickness of the electrically conducting polymer varies along the reaction vessel so as to reduce thermal gradients therealong. 13. The reaction vessel according to claim 1 wherein the passivated outer surface of the metallic layer comprises a layer of anodized aluminum. 14. The reaction vessel according to claim 1 wherein the passivated outer surface of the metallic layer comprises a polymer layer. 15. The reaction vessel according to claim 14 wherein the polymer layer a compound of formula (I) where R is a substituent group selected from R1, OR1, SR1, OC(O)R1, C(O)OR1, hydroxyl, halogen, nitro, nitrile, amine, carboxy or mercapto and where R1 is any hydrocarbon group and where R1 may be optionally substituted by one or more groups selected from hydroxyl, halogen, nitro, nitrile, amine or mercapto; and where m is 0 or an integer of from 1 to 3; and n is sufficient for the compound to be a polymer. 16. A reaction system comprising a reaction vessel according to claim 1, and an apparatus which accommodates said reaction vessel, and the apparatus comprises a heating system adapted to controllably heat and cool said reaction vessel. 17. The reaction system according to claim 16 wherein the heating system is an induction heating system, able to interact with the metallic layer of the reaction vessel so as to heat it by induction. 18. The reaction system according to claim 16 wherein the heating system supplies heated fluid to the reaction vessel or a vicinity thereof, so as to effect heating, and is also able to supply non-heated fluid to the reaction vessel or the vicinity thereof, so as to effect cooling. 19. The reaction system according to claim 18 wherein the heated fluid is air. 20. The reaction system according to claim 16 wherein the heating system is connected to the integral resistive heating element. 21. The reaction system according to claim 20 wherein the apparatus comprises a solid foam material arranged in direct contact with at least one electrical connector of the integral resistive heating element. 22. The reaction system according to claim 21 wherein the foam material is a honeycomb or reticulated foam. 23. The reaction system according to claim 21 wherein the foam material forms a pillared or corrugated mount for the electrical connector. 24. The reaction system according to claim 16 wherein the apparatus is able to accommodate multiple reaction vessels. 25. A method for carrying out a chemical or biochemical reaction which requires at least one heating step, said method comprising placing chemical or biochemical reagents into said reaction vessel according to claim 1 and heating said reagents so as to bring about said chemical or biochemical reaction. 26. The method according to claim 25 wherein the reaction requires thermal cycling. 27. The method according to claim 26 wherein the reaction is a polymerase chain reaction. 28. A method for carrying out a chemical or biochemical reaction which requires at least one heating step, said method comprising placing chemical or biochemical regiments into the reaction vessel of the reaction system according to claim 16 and heating said reagent so as to bring about said chemical or biochemical reaction.
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