Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A01N-063/00
C12N-005/073
A61L-027/38
A61M-001/02
C12N-005/00
A61K-035/12
출원번호
US-0863308
(2013-04-15)
등록번호
US-9139813
(2015-09-22)
발명자
/ 주소
Hariri, Robert J.
출원인 / 주소
Anthrogenesis Corporation
대리인 / 주소
Day, Jones
인용정보
피인용 횟수 :
1인용 특허 :
100
초록▼
A method of manufacturing a tissue matrix for implantation into a patient is disclosed. The method sets forth collecting embryonic stem cells from a placenta which has been treated to remove residual cord blood and seeding the collected stem cells onto or into a tissue matrix. The seeded tissue matr
A method of manufacturing a tissue matrix for implantation into a patient is disclosed. The method sets forth collecting embryonic stem cells from a placenta which has been treated to remove residual cord blood and seeding the collected stem cells onto or into a tissue matrix. The seeded tissue matrix is then implanted on or into a patient. The seeded tissue matrix made by the method of the present invention is also disclosed.
대표청구항▼
1. A method of treating an individual in need of repair of traumatic injury of the skin comprising administering to the individual isolated placental stem cells, wherein said isolated placental stem cells have been seeded onto a decellularized or synthetic tissue matrix, wherein said placental stem
1. A method of treating an individual in need of repair of traumatic injury of the skin comprising administering to the individual isolated placental stem cells, wherein said isolated placental stem cells have been seeded onto a decellularized or synthetic tissue matrix, wherein said placental stem cells are obtained from a mammalian placenta that has been drained of cord blood, and wherein said placental stem cells (a) express antigens recognized by SH2, SH3 and SH4 antibodies;(b) do not express MHC Class 2 antigens;(c) are CD34−, SSEA3−, SSEA4−, and OCT-4+;(d) are SSEA3−, SSEA4−, OCT-4+ and ABC-p+; or(e) are CD10+, CD29+, CD34−, CD44+, CD45−, CD54+, CD90+, SH2+, SH3+, SH4+, SSEA3−, SSEA4−, OCT-4+ and ABC-p+. 2. The method of claim 1, wherein said placental stem cells express antigens recognized by SH2, SH3 and SH4 antibodies. 3. The method of claim 1, wherein said placental stem cells do not express MHC Class 2 antigens. 4. The method of claim 1, wherein said placental stem cells are CD34−, SSEA3−, SSEA4−, and OCT-4+. 5. The method of claim 1, wherein said placental stem cells are SSEA3−, SSEA4−, OCT-4+ and ABC-p+. 6. The method of claim 1, wherein said placental stem cells are CD10+, CD29+, CD34−, CD44+, CD45−, CD54+, CD90+, SH2+, SH3+, SH4+, SSEA3−, SSEA4−, OCT-4+, and ABC-p+.
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이 특허에 인용된 특허 (100)
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Palsson Bernhard O. (Ann Arbor MI) Armstrong R. Douglas (Ann Arbor MI) Clarke Michael F. (Ann Arbor MI) Emerson Stephen G. (Ann Arbor MI), Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture.
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Yannas Ioannis V. (Newton Center MA) Burke John F. (Belmont MA) Gordon Philip L. (Lexington MA) Huang Chor (Avon Lake OH), Multilayer membrane useful as synthetic skin.
McIntosh, Kevin; Klyushnenkova, Elena, Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation.
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