초록 ▼

Provided herein are powder-free elastomeric articles exhibiting good antimicrobial and anti-blocking properties. Also provided herein are methods for the manufacture of such articles substantially free from antimicrobial interfering materials, as well as packaging means for maintaining antimicrobial

Provided herein are powder-free elastomeric articles exhibiting good antimicrobial and anti-blocking properties. Also provided herein are methods for the manufacture of such articles substantially free from antimicrobial interfering materials, as well as packaging means for maintaining antimicrobial efficacy.

대표청구항 ▼

1. A powder-free, antimicrobial glove, for use on a user's hand, comprising: an elastomeric layer having an interior surface that contacts the hand and an exterior surface;an antimicrobial gel coating comprising one or more antimicrobial agents covering the interior surface of the elastomeric layer;

1. A powder-free, antimicrobial glove, for use on a user's hand, comprising: an elastomeric layer having an interior surface that contacts the hand and an exterior surface;an antimicrobial gel coating comprising one or more antimicrobial agents covering the interior surface of the elastomeric layer; anda solid film comprising a water-soluble polymer coating disposed on the antimicrobial gel coating and over-covering the interior surface, wherein the antimicrobial gel would dispose the glove to blocking in the absence of the film, wherein the film inhibits such blocking, wherein the anti-blocking film coating dissolves upon contact with moisture to release the antimicrobial gel coating onto the user's hand. 2. The glove of claim 1, wherein the elastomeric layer comprises a cured latex selected from the group consisting of natural latex, synthetic latex, and blends of natural and synthetic latex. 3. The glove of claim 2, wherein the synthetic latex is selected from the group consisting of polychloroprene, carboxylated acrylonitrile butadiene, polyisoprene, polyurethane, styrene-butadiene, and combinations thereof. 4. The glove of claim 1, wherein the antimicrobial gel coating comprises one or more antimicrobial agents selected from the group consisting of chlorhexidine gluconate (CHG), polyhexamethylene biguanide hydrochloride (PHMB), benzalkonium chloride (BZK), benzethonium chloride (BZT), triclosan, farnesol, phenoxyethanol, octoxyglycerin, iodine compounds, silver salts, antifungal agents, antiviral agents, and combinations thereof. 5. The glove of claim 1, wherein the one or more antimicrobial agents are encapsulated. 6. The glove of claim 5, wherein the one or more antimicrobial agents are contained within microcapsules having a hydrophobic shell. 7. The glove of claim 1, wherein the antimicrobial gel coating comprises a zinc gel formulation. 8. The glove of claim 7, wherein the zinc gel formulation comprises one or more water-soluble zinc salts, panthenol, and a gelling agent. 9. The glove of claim 1, wherein the anti-blocking film coating is cellulose-based, comprising a cellulosic water-soluble polymer. 10. The glove of claim 9, wherein the cellulosic water-soluble polymer of the antiblocking film coating is selected from the group consisting of hydroxylpropylcellulose (HPC), hydroxypropylmethylcellulose (HPMC), methyl cellulose (MC), and combinations thereof. 11. The glove of claim 9, the film coating comprising a heat-cured film of the water-soluble polymer, which has a lower critical solution temperature (LCST) greater than 40° C., the greater solubility of the film below the LCST permitting dissolution of anti-blocking film coating by skin-generated moisture. 12. The glove of claim 1 having less than 2 mg of powder. 13. The glove of claim 1, wherein an antimicrobial agent from the antimicrobial gel coating is released from the glove following dissolution of the anti-blocking film coating. 14. The glove of claim 1, wherein the antimicrobial gel coating exhibits a reduction in bacterial growth of at least 3 log following a 2 minute exposure. 15. The glove of claim 1, wherein the antimicrobial gel coating exhibits substantially no loss of antimicrobial activity following aging at 50° C. for 8 weeks and 40° C. for 6 months. 16. A packaged powder-free, antimicrobial article comprising the powder-free, antimicrobial glove of claim 1 packaged in an inner wrap surrounded by and sealed within an outer pack, wherein the outer pack is sealed to contain a cushioning amount of gas to allow the inner wrap to freely move within the outer pack. 17. A powder free, antimicrobial elastomeric article, for contacting a user's skin, comprising: an elastomeric layer having an interior surface that contacts the hand and an exterior surface; an antimicrobial gel coating comprising one or more antimicrobial agents disposed on the interior surface of the elastomeric layer; and a solid film coating comprising a water-soluble polymer disposed on the antimicrobial gel coating and over-covering the interior surface, wherein the antimicrobial gel would dispose the article to blocking in the absence of the film, wherein the film inhibits such blocking, wherein the anti-blocking film coating dissolves upon contact with moisture to release the antimicrobial gel coating onto the user's skin. 18. The article of claim 17 in the form of a glove, wherein the elastomeric layer comprises a cured latex of natural rubber, the antimicrobial gel coating comprises polyquaternium 10, zinc lactate, zinc acetate, zinc gluconate, chlorhexidine gluconate (CRG), phenoxyethanol, benzethonium chloride (BZT), octoxyglycerine, farnesol, and panthenol; and the anti-blocking film coating comprises hydroxypropylcellulose. 19. A process for preparing a powder-free, antimicrobial glove comprising: providing an elastomeric layer having an interior surface and an exterior surface;providing an antimicrobial gel coating comprising one or more antimicrobial agents to the interior surface of the elastomeric layer;applying an a water-containing anti-blocking film coating composition comprising a water-soluble polymer to the dry antimicrobial gel coating; anddrying the anti-blocking film coating to remove water and form the a solid anti-blocking film covering the antimicrobial gel coating. 20. The process of claim 19, wherein the anti-blocking film coating comprises a cellulosic water-soluble polymer; and the drying step comprises: drying the anti-blocking film coating at a temperature greater than the low critical solution temperature of the cellulosic water-soluble polymer to form a liquid film, andfurther drying of the liquid film to form a solid film covering said antimicrobial gel coating. 21. The process of claim 19, further comprising forming an additional elastomeric layer, or applying an additional coating, or both between the elastomeric layer and the antimicrobial gel coating. 22. The process of claim 19, further comprising water-washing the glove prior to applying the antimicrobial gel coating. 23. The process of claim 19, wherein the antimicrobial gel coating comprises polyquaternium 10, zinc lactate, zinc acetate, zinc gluconate, chlorhexidine gluconate (CHG), phenoxyethanol, benzethonium chloride (BZT), octoxyglycerine, farnesol and panthenol. 24. The process of claim 19, further comprising packaging the powder-free, antimicrobial glove in an inner wrap surrounded by and sealed within an outer pack, wherein the outer pack is sealed to contain a sufficient amount of gas to allow the inner wrap to freely move within the outer pack. 25. The process of claim 19, wherein the step of providing an elastomeric layer having an interior surface and an exterior surface comprises dipping a pre-heated former into a powder free coagulant composition, drying the coagulant composition on the former, dipping the former into a latex solution comprising natural and/or synthetic elastomers, and leaching the gelled latex on the former in hot water. 26. The glove of claim 9, wherein the anti-blocking film further comprises a water-insoluble occlusive moisturizer. 27. The glove of claim 26, wherein the water-insoluble occlusive moisturizer is aminofunctional siloxane, polydimethylsiloxane (dimethicone), oleyl erucate, or combinations thereof.