Optical capsule and spectroscopic method for treating and diagnosing the intestinal tract
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-005/00
A61B-005/06
A61B-001/04
A61B-005/07
A61B-005/03
A61B-005/11
A61B-005/145
A61M-005/172
A61B-001/00
A61N-001/36
A61N-001/372
출원번호
US-0139336
(2013-12-23)
등록번호
US-9167990
(2015-10-27)
발명자
/ 주소
Imran, Mir A.
출원인 / 주소
Entrack, Inc.
대리인 / 주소
Mahamedi Paradice LLP
인용정보
피인용 횟수 :
0인용 특허 :
62
초록▼
A device and method for mapping, diagnosing and treating disorders or other diseases, disorders or conditions (e.g., bleeding, ischemic or necrotic tissue, and presence of certain chemicals or substances) of the intestinal tract is provided using a capsule passing through the intestinal tract and se
A device and method for mapping, diagnosing and treating disorders or other diseases, disorders or conditions (e.g., bleeding, ischemic or necrotic tissue, and presence of certain chemicals or substances) of the intestinal tract is provided using a capsule passing through the intestinal tract and sensing optical characteristics as the capsule passes through. Further, a capsule tracking system is provided for tracking a capsule's location along the length of an intestinal tract as various treatment and/or sensing modalities are employed. In one variation, an acoustic signal is used to determine the location of the capsule. A map of optical characteristics may be derived from the pass of a capsule to diagnose the disorder or disease. The capsule or subsequently passed capsules may treat, further diagnose or mark the intestinal tract at a determined location along its length.
대표청구항▼
1. A diagnostic system comprising: an autonomous capsule sized to pass through an intestinal tract of a patient, the capsule comprising: a light source configured to emit light from the capsule so that the emitted light is reflected from intestinal tract tissue when the capsule is moving through the
1. A diagnostic system comprising: an autonomous capsule sized to pass through an intestinal tract of a patient, the capsule comprising: a light source configured to emit light from the capsule so that the emitted light is reflected from intestinal tract tissue when the capsule is moving through the intestinal tract; and a sensor configured to sense reflected light for at least one predetermined wavelength at a first location within the intestinal tract and to output a signal representative of light sensed by the sensor at the at least one predetermined wavelength, each at least one predetermined wavelength associated with a corresponding condition of intestinal tract tissue;a processor coupled to the sensor and configured to receive a signal representative of light sensed by the sensor, the processor further configured to associate each of the at least one predetermined wavelength with the corresponding condition of intestinal tract tissue, to select a gastrointestinal condition of intestinal tract tissue for detection, to control the emission of light from the light source for detecting the selected condition, to control wavelengths of light sensed by the sensor, and to determine the presence of the condition of intestinal tract tissue based at least in part on the received signal, the condition being at least one of a presence of a substance, an absence of a substance, or a condition of tissue of the intestinal tract;a capsule tracking system configured to track a location of the capsule within the intestinal tract independent of capsule orientation, via calculating a transmission time of an acoustic tracking signal transmitted from one of (a) the autonomous capsule or (b) a location external a patient's body, to the other of the autonomous capsule or the location external to the patient's body, anda battery disposed within the capsule for powering the light source, the sensor, and portions of the capsule tracking system as the capsule is moving through the intestinal tract, the battery configured to allow the capsule to emit and sense light along a length of the intestinal tract when the acoustic tracking signal is transmitted without receiving external power, so as to develop a map of sensed optical characteristics along the length of the intestinal tract. 2. The system of claim 1, wherein the light source emits light at the at least one predetermined wavelength. 3. The system of claim 1, wherein the capsule further comprises a filter coupled to the sensor, wherein the filter is configured to filter light of the at least one predetermined wavelength into the sensor. 4. The system of claim 1, wherein the capsule tracking system is configured to track the location of the capsule within a three-dimensional coordinate system. 5. The system of claim 4, wherein the processor is coupled to the capsule tracking system to receive information on the location of the capsule within the intestinal tract, and wherein the processor is arranged to identify a location of the selected gastrointestinal condition of intestinal tract tissue within the portion of the intestinal tract. 6. The system of claim 1, wherein the capsule tracking system is configured to track a location of the capsule along a length of a portion of the intestinal tract. 7. The system of claim 6, wherein the processor is coupled to the capsule tracking system to receive information on the location of the capsule within the intestinal tract, and wherein the processor is configured to identify a location of a sensed condition along the length of the portion of the intestinal tract. 8. The system of claim 6, further comprising a mapping element configured to map locations of the capsule along the length of the portion of the intestinal tract with respect to conditions sensed by the sensor at corresponding locations along the length of the portion of the intestinal tract. 9. The system of claim 8, further comprising: a display coupled to the processor, the display being configured to display a diagnostic map of sensed conditions of the intestinal tract along the length of the portion of the intestinal tract. 10. The system of claim 7, wherein the capsule tracking system is configured to determine capsule location along the length the portion of the intestinal tract, from a determination of a plurality of locations of the capsule as the capsule passes through the portion of the intestinal tract. 11. The system of claim 1, wherein the capsule tracking system comprises: an acoustic transducer transmitter located at the one of the autonomous capsule or the location external to the patient's body, and an acoustic transducer receiver located at the other of the autonomous capsule or the location external to the patient's body, and wherein the acoustic tracking signal is transmitted from the acoustic transmitter to the acoustic receiver. 12. The system of claim 1, wherein: the capsule tracking system comprises:a plurality of acoustic transducers at the capsule, each of the plurality of acoustic transducers being arranged to emit an acoustic signal detectable externally of a patient's body as the capsule passes through at least a portion of the intestinal tract; andat least one external acoustic receiver configured to sense the acoustic signal transmitted by the capsule,wherein the acoustic signal of each of the plurality of acoustic transducers provides information from which the location of the capsule may be derived. 13. The system of claim 1, wherein the capsule further comprises: a telemetry device arranged to transmit a telemetry signal corresponding to the light sensed by the sensor, and a telemetry receiver for receiving the telemetry signal. 14. The system of claim 13, wherein the processor is located in an external device coupled to the telemetry receiver. 15. The system of claim 1, wherein the capsule further comprises a marking mechanism configured to mark an identified location of a condition within the intestinal tract. 16. The system of claim 15, wherein the marking mechanism comprises a substance release mechanism. 17. The system of claim 16, wherein the substance release mechanism comprises a dye release mechanism. 18. The system of claim 15, wherein the marking mechanism comprises a position anchoring mechanism. 19. The system of claim 1, wherein the presence of the condition comprises a presence of blood on a surface of the intestinal tract. 20. The system of claim 1, wherein the presence of the condition comprises an absence of blood in tissue. 21. The system of claim 1, wherein the presence of the condition comprises a presence of ischemic tissue. 22. The system of claim 1, wherein the presence of the condition comprises a presence of necrotic tissue. 23. The system of claim 1, wherein the presence of the condition comprises a presence of hemoglobin or an absence of hemoglobin. 24. The system of claim 23, wherein at least one of the at least one predetermined wavelength is within a range between about 540 nanometers and about 620 nanometers. 25. The system of claim 1, further comprising a treatment capsule configured to treat the condition determined to be present. 26. The system of claim 25, wherein the treatment capsule comprises a treatment capsule tracking system configured to track the location of the capsule and identify the location of the condition determined by the capsule. 27. The system of claim 26, wherein the treatment capsule tracking system is configured to track the location of the treatment along the length of at least a portion of the intestinal tract. 28. A diagnostic system comprising: an autonomous capsule sized to pass through an intestinal tract of a patient, the capsule comprising: a light source configured to emit light from the capsule so that the emitted light is reflected from intestinal tract tissue when the capsule is moving through the intestinal tract; and a sensor configured to sense light for at least one predetermined wavelength and to output a signal representative of light sensed by the sensor at the at least one predetermined wavelength, each at least one predetermined wavelength associated with a presence of blood within the intestinal tract at a first location;a processor coupled to the sensor and configured to receive a signal representative of light sensed by the sensor, the processor further configured to select the presence of blood as a condition to be detected, associate each of the at least one predetermined wavelength with the presence of blood within the intestinal tract, to control the emission of light from the light source for detecting presence of blood in the intestinal tract, to control wavelengths of light sensed by the sensor, and to detect bleeding in the gastrointestinal tract by determining the presence of blood at the first location within the intestinal tract based at least in part on the received signal;a capsule tracking system configured to track a location of the capsule within the intestinal tract independent of capsule orientation, via calculating a transmission time of an acoustic tracking signal transmitted from one of (a) the autonomous capsule or (b) a location external a patient's body, to the other of the autonomous capsule or the location external to the patient's body; anda battery disposed within the capsule for powering the light source, the sensor, and portions of the capsule tracking system as the capsule is moving through the intestinal tract, the battery configured to allow the capsule to emit and sense light along a length of the intestinal tract when the acoustic tracking signal is transmitted without receiving external power so as to develop a map of a sensed optical characteristics along the length of the intestinal tract. 29. The system of claim 28, wherein at least one of the at least one predetermined wavelength is within a range between about 540 nanometers and about 620 nanometers.
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