Systems and methods for detecting the presence of a selected volume of material in a sample processing device
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-021/00
B01L-003/00
출원번호
US-0474903
(2012-05-18)
등록번호
US-9168523
(2015-10-27)
발명자
/ 주소
Ludowise, Peter D.
Whitman, David A.
Armantrout, Kyle C.
Exner, Maurice
Jacky, Lucien A. E.
Tabb, Michelle
출원인 / 주소
3M Innovative Properties Company
대리인 / 주소
Mueting, Raasch & Gebhardt, P.A.
인용정보
피인용 횟수 :
12인용 특허 :
244
초록▼
Systems and methods for processing sample processing devices. The system can include a sample processing device comprising a detection chamber, a motor configured to rotate the sample processing device about an axis of rotation, and an optical module operatively positioned relative to the sample pro
Systems and methods for processing sample processing devices. The system can include a sample processing device comprising a detection chamber, a motor configured to rotate the sample processing device about an axis of rotation, and an optical module operatively positioned relative to the sample processing device and configured to determine whether a selected volume of material is present in the detection chamber of the sample processing device. The method can include rotating the sample processing device about an axis of rotation, and determining whether a selected volume of material is present in the detection chamber, while rotating the sample processing device. In some embodiments, determining whether a selected volume of material is present can be performed by optically interrogating the detection chamber for an optical property of the material.
대표청구항▼
1. A method for processing sample processing devices, the method comprising: providing a sample processing device comprising a detection chamber;rotating the sample processing device about an axis of rotation; anddetermining whether a selected volume of material is present in the detection chamber,
1. A method for processing sample processing devices, the method comprising: providing a sample processing device comprising a detection chamber;rotating the sample processing device about an axis of rotation; anddetermining whether a selected volume of material is present in the detection chamber, while rotating the sample processing device. 2. The method of claim 1, wherein determining whether a selected volume of material is present in the detection chamber includes optically interrogating the detection chamber at a selected position to determine whether the material is present at the selected position. 3. The method of claim 1, wherein determining whether a selected volume of material is present in the detection chamber includes optically interrogating the detection chamber for an optical property of a sample to determine whether the sample is present in the detection chamber. 4. The method of claim 1, wherein the detection chamber includes an inner boundary located nearest the axis of rotation, and wherein determining whether a selected volume of material is present in the detection chamber includes optically interrogating the detection chamber at a gantry position proximate the inner boundary of the detection chamber. 5. The method of claim 2, wherein optically interrogating the detection chamber includes optically interrogating the detection chamber for a meniscus. 6. The method of claim 2, wherein optically interrogating the detection chamber includes emitting an electromagnetic signal into the detection chamber, andobtaining a scan by detecting backscattered reflection of the electromagnetic signal, after emitting the electromagnetic signal into the detection chamber. 7. The method of claim 6, wherein obtaining a scan includes: obtaining a first background scan of the detection chamber,obtaining a second scan of the detection chamber after positioning a sample in the detection chamber, andcomparing the first background scan with the second scan to determine whether a selected volume of the sample is located in the detection chamber. 8. The method of claim 7, wherein comparing the first background scan with the second scan to determine whether a selected volume of the sample is located in the detection chamber includes determining whether a threshold change exists between the first background scan and the second scan. 9. The method of claim 8, further comprising providing an optical module operatively positioned relative to the sample processing device on a gantry, wherein optically interrogating the detection chamber includes optically interrogating the detection chamber with the optical module at a plurality of radial positions, relative to the axis of rotation. 10. The method of claim 9, further comprising: determining a radial position at which a threshold change is found between the first background scan and the second scan; andusing the radial position to determine the volume of the sample that is located in the detection chamber. 11. The method of claim 2, wherein optically interrogating includes emitting an electromagnetic signal into the detection chamber, andobtaining a scan by detecting fluorescence emitted by a material in the detection chamber, after emitting the electromagnetic signal into the detection chamber. 12. The method of claim 11, wherein obtaining a scan includes: obtaining a first background scan of the detection chamber,obtaining a second scan of the detection chamber after positioning a sample in the detection chamber, andcomparing the first background scan with the second scan to determine whether a selected volume of the sample is present in the detection chamber. 13. The method of claim 12, wherein comparing the first background scan with the second scan to determine whether a selected volume of the sample is located in the detection chamber includes determining whether a threshold change in fluorescence exists between the first background scan and the second scan. 14. The method of claim 13, further comprising providing an optical module operatively positioned relative to the sample processing device on a gantry, wherein interrogating the detection chamber includes optically interrogating the detection chamber with the optical module at a plurality of radial positions, relative to the axis of rotation. 15. The method of claim 14, further comprising: determining a radial position at which a threshold change in fluorescence is found between the first background scan and the second scan; andusing the radial position to determine the volume of the sample that is present in the detection chamber. 16. The method of claim 15, further comprising: heating the detection chamber,wherein determining whether a selected volume of material is present in the detection chamber occurs while heating the detection chamber. 17. The method of claim 2, wherein optically interrogating includes emitting an electromagnetic signal into the detection chamber at a first wavelength, anddetecting electromagnetic signals emitted from the detection chamber at a second wavelength, after emitting the electromagnetic into the detection chamber at a first wavelength. 18. The method of claim 2, wherein material includes a sample to be analyzed and reagent media, and wherein optically interrogating the detection chamber includes optically interrogating the detection chamber for an optical property of at least one of the sample and the reagent media in the detection chamber. 19. The method of claim 2, further comprising providing an optical module operatively positioned relative to the sample processing device on a gantry, and wherein optically interrogating the detection chamber includes optically interrogating the detection chamber with the optical module located at a predetermined gantry position. 20. The method of claim 2, further comprising providing an optical module operatively positioned relative to the sample processing device on a gantry, and wherein optically interrogating the detection chamber includes optically interrogating the detection chamber with the optical module at a plurality of gantry positions. 21. The method of claim 20, wherein each of the plurality of gantry positions is associated with an amount of material, and further comprising: detecting a threshold signal at a gantry position; andcorrelating the gantry position to an amount of material that is present in the detection chamber. 22. The method of claim 20, wherein the plurality of gantry positions includes different radial positions in the detection chamber, relative to the axis of rotation. 23. The method of claim 1, wherein rotating the sample processing device while determining whether a selected volume of material is present in the detection chamber forces any material present in the detection chamber to a position in the detection chamber that is located furthest from the axis of rotation. 24. The method of claim 1, wherein the detection chamber includes an outer boundary positioned furthest from the axis of rotation, and wherein rotating the sample processing device while determining whether a selected volume of material is present in the detection chamber forces any material present in the detection chamber toward the outer boundary of the detection chamber. 25. A method for processing sample processing devices, the method comprising: providing a sample processing device comprising a detection chamber;rotating the sample processing device about an axis of rotation; andoptically interrogating the detection chamber for an optical property of a material to determine whether the material is present in the detection chamber, wherein optically interrogating occurs while rotating the sample processing device. 26. The method of claim 25, wherein rotating the sample processing device about an axis of rotation causes the sample to move to the detection chamber. 27. A method for processing sample processing devices, the method comprising: providing a sample processing device comprising a processing array, the processing array comprising: an input chamber,a detection chamber, anda channel positioned to fluidly couple the input chamber and the detection chamber;positioning a sample in the input chamber of the processing array of the sample processing device;rotating the sample processing device about an axis of rotation to move the sample to the detection chamber;after rotating the sample processing device to move the sample to the detection chamber, optically interrogating the detection chamber for an optical property of the sample to determine whether the sample has moved to the detection chamber; androtating the sample processing device while optically interrogating the detection chamber.
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이 특허에 인용된 특허 (244)
Cox,David M.; Bryning,Zbigniew T., Actuator for deformable valves in a microfluidic device, and method.
Sheppard ; Jr. Norman F. ; Mian Alec ; Kellogg Gregory ; Kieffer-Higgins Stephen G. ; Carvalho Bruce L., Affinity binding-based system for detecting particulates in a fluid.
Zaun Peter (Libertyville IL) Bouma Stanley R. (Grayslake IL) Gordon Julian (Lake Bluff IL) Kotlarik John J. (Vernon Hills IL), Apparatus and method for amplifying and detecting target nucleic acids.
Woudenberg Timothy M. ; Bodner Kevin S. ; Connell Charles R. ; Shigeura John ; Tracy David H. ; Young Eugene F., Apparatus and method for detecting nucleic acid amplification products.
Gjerde Douglas T. ; Hanna Christopher P. ; Taylor Paul D. ; Legendre ; Jr. Benjamin L. ; Haefele Robert M., Apparatus and method for separating and purifying polynucleotides.
Harrison, D. Jed; Oleschuk, Richard; Shultz-Lockyear, Loranelle; Skinner, Cameron; Li, Paul, Apparatus and method for trapping bead based reagents within microfluidic analysis systems.
Harrison,D. Jed; Oleschuk,Richard; Shultz Lockyear,Loranelle; Skinner,Cameron; Li,Paul, Apparatus and method for trapping bead based reagents within microfluidic analysis systems.
Richards William ; Lemme Charles D. ; Christensen Kimberly ; Macrea Ethel R., Automated molecular pathology apparatus having independent slide heaters.
Tseung Ken (Fremont CA) Wong Wai Bun (Fremont CA) Takayama Glenn K. (Danville CA) Jones Christopher M. (Walnut Creek CA) Kalra Krishan L. (Danville CA), Automated staining apparatus.
Parthasarathy, Ranjani V.; Rajagopal, Raj; Bedingham, William; Dirksen, Michael D.; Larson, Christopher J.; Menon, Vinod P., Biological sample processing methods and compositions that include surfactants.
Roger Hammer ; William O. Reid, Jr. ; David Storvick ; Richard A. Riedel ; James S. Hutchison ; Daniel Kennedy ; John W. Stoughton ; James J. Ramey ; Glen T. Mathews, Cartridge-based analytical instrument with rotor balance and cartridge lock/eject system.
Kellogg,Gregory J.; Carvalho,Bruce L.; Sheppard, Jr.,Norman F.; Noonan,Kevin E., Centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids.
Curtis Huntington W. (Chelsea NY) Kellogg Robert M. (Washington Crossing PA) Kissinger Kerry W. (Pennington NJ) Mappes Robert P. (Cranbury NJ) Stephans Emery J. (Plainsboro NJ), Chemical analysis system including a test package and rotor combination.
Heidt Thomas (Long Valley NJ) Will Henry (Dover NJ) Rhodes Greydon (Chester NJ) Plasensia Armand (Hopatcong NJ) Clampitt Roger (Hemel Hempstead GBX), Chemical analyzer.
Schnipelsky Paul N. (Rochester NY) Seaberg Leonard J. (Penfield NY) Hinckley Charles C. (Pittsford NY) Wellman Jeffrey A. (Rochester NY) Donish William H. (Rochester NY) Findlay John B. (Rochester NY, Containment cuvette for PCR and method of use.
Schnipelsky, Paul Nicholas; Seaberg, Leonard Joseph; Hinckley, Charles Cullis; Wellman, Jeffrey Allen; Donish, William Harold; Findlay, John Bruce, Containment cuvette for PCR and method of use.
Uffenheimer Kenneth F. (Mahopac NY) Svenjak Dario (Fairview NJ) Diebler Herman G. (Redding CT) McCandless William J. C. (Ringwood NJ) Herron Rand E. (Wilton CT) Saros Stephen (Wantagh NY), Cuvette tray.
Kellogg Gregory ; Kieffer-Higgins Stephen G. ; Carvalho Bruce L. ; Davis Gene A. ; Willis John P. ; Minior Ted ; Chapman Laura L. ; Kob Mikayla ; Oeltjen Sarah D. ; Ommert Shari ; Mian Alec, Device and method for using centripetal acceleration to device fluid movement on a microfluidics system.
Fisk, Raymond P.; Iraneta, Pamela Carmen; Tuvim, Yuri; Bouvier, Edouard S. P.; Belanger, Jonathan; Gilar, Martin, Device for solid phase extraction and method for purifying samples prior to analysis.
Pourahmadi, Farzad; McMillan, William A.; Ching, Jesus; Chang, Ronald; Christel, Lee A.; Kovacs, Gregory T. A.; Northrup, M. Allen; Petersen, Kurt E., Device incorporating a microfluidic chip for separating analyte from a sample.
Kellogg, Gregory J.; Able, Charles; Arnold, Todd; Carvalho, Bruce L.; Lin, Hsin-Chiang; Kieffer-Higgins, Stephen; Sheppard, Norman F.; Kob, Mikayla; Ommert, Shari, Devices and methods for the performance of miniaturized in vitro amplification assays.
Kellogg, Gregory; Kieffer-Higgins, Stephen G.; Carvalho, Bruce L.; Davis, Gene A.; Willis, John P.; Minior, Ted; Chapman, Laura L.; Kob, Mikayla; Oeltjen, Sarah D.; Ommert, Shari; Mian, Alec, Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system.
Mian Alec ; Kieffer-Higgins Stephen G. ; Corey George D., Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system.
Mian, Alec; Kieffer-Higgins, Stephen G.; Corey, George D., Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system.
Kellogg, Gregory; Kieffer-Higgins, Stephen G.; Jensen, Mona D.; Ommert, Shari; Kob, Mikayla; Pierce, Andrea; Morneau, Keith; Lin, Hsin Chiang, Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system for performing biological fluid assays.
Kellogg Gregory ; Kieffer-Higgins Stephen G. ; Carvalho Bruce L. ; Davis Gene A. ; Willis John P. ; Minior Ted ; Chapman Laura L. ; Kob Mikayla ; Oeltjen Sarah D. ; Ommert Shari ; Mian Alec, Devices and methods for using centripetal acceleration to drive fluid movement on a microfluidics system.
English Kenneth P. (Bolingbrook IL) Micek ; III Stanley E. (Grayslake IL) O\Connell Michael B. (Waukegan IL) Tripp Edward S. (Park City IL), Diagnostic testing device.
Kellogg, Gregory; Kieffer-Higgins, Stephen G.; Carvalho, Bruce L.; Davis, Gene A.; Willis, John P.; Minior, Ted; Chapman, Laura L.; Kob, Mikayla; Oeltjen, Sarah D.; Ommert, Shari; Mian, Alec, Electronic spindle for using centripetal acceleration to drive fluid movement in a microfluidics system.
Swedberg Sally A. (Los Altos CA) Kaltenbach Patrick (Bischweier DEX) Witt Klaus E. (Keltern DEX) Bek Fritz (Waldbronn DEX) Mittelstadt Laurie S. (Belmont CA), Fully integrated miniaturized planar liquid sample handling and analysis device.
Farzad Pourahmadi ; William A. McMillan ; Jesus Ching ; Ronald Chang ; Lee A. Christel ; Gregory T. A. Kovacs ; M. Allen Northrup ; Kurt E. Petersen, Integrated fluid manipulation cartridge.
Kelton Arden A. (Westminster CA) Waters William P. (Newport Beach CA) Shrunk David G. (Poway CA) Bell Michael L. (Hacienda Heights CA), Integrated fluid manipulator.
Burdon, Jeremy W.; Huang, Rong-Fong; Wilcox, David; Naclerio, Nicholas J.; Briscoe, Cynthia Ann Gorsuch; Grodzinski, Piotr; Yu, Huinan; Marrero, Robert; Gallagher, Sean Ross; Chan, Yuk-Tong; Foley, B, Integrated multilayered microfludic devices and methods for making the same.
Zanzucchi Peter John ; Cherukuri Satyam Choudary ; McBride Sterling Edward ; Demers Robert R. ; Levine Aaron W. ; Thaler Barry Jay ; Quinn Robert Leon ; Braun Paul Leonard ; Chiang William ; Fan Zhon, Liquid distribution system.
Meador James W. (Houston TX) Miller Thomas G. (Houston TX) Nikirk Christopher T. (Houston TX) Waters ; Jr. Louis A. (Bellaire TX) Donnelly Sean M. (Houston TX), Liquid specimen transfer apparatus and method.
Mehta, Tammy Burd; Kopf-Sill, Anne R.; Parce, J. Wallace; Chow, Andrea W.; Bousse, Luc J.; Knapp, Michael R.; Nikiforov, Theo T.; Gallagher, Steve, Manipulation of microparticles in microfluidic systems.
Potter Derek Henry,GBX ; Potter Colin Gerald,GBX ; Old John Michael,GBX ; Bell John Irving,GBX, Method and apparatus for temperature control of multiple samples.
Arnquist David C. ; Barnes ; III Grady ; Button Richard D. ; Dunn Chadwick M. ; East ; Jr. Richard C. ; Fritchie Patrick P. ; Galitz Charles M. ; Gardner Gregory E. ; Grandone Cass J. ; Gray Robert C, Method for determination of item of interest in a sample.
Nieuwkerk Yolanda (La Jolla CA) Barry Robert J. (Kittery ME) Pluskal Malcolm G. (Acton MA) Hamilton Richard A. (Beverly MA), Method for rapid purifiction of nucleic acids using layered ion-exchange membranes.
Wilding Peter (Paoli PA) Kricka Larry J. (Berwyn PA) Zemel Jay N. (Jenkintown PA), Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems.
Parthasarathy,Ranjani V.; Rajagopal,Raj; Morris,Vicky L.; Bedingham,William; Robole,Barry W., Methods and devices for removal of organic molecules from biological mixtures using a hydrophilic solid support in a hydrophobic matrix.
Parthasarathy, Ranjani V; Rasmussen, Rusty A., Methods and devices for removal of organic molecules from biological mixtures using an anion exchange material that includes a polyoxyalkylene.
Parthasarathy, Ranjani V.; Rajagopal, Raj; Olson, Erin E.; Beissel, IV, Frank J.; Bedingham, William; Robole, Barry W., Methods and devices for removal of organic molecules from biological mixtures using anion exchange.
Parthasarathy,Ranjani V.; Rajagopal,Raj; Olson,Erin E.; Beissel, IV,Frank J.; Bedingham,William; Robole,Barry W., Methods and devices for removal of organic molecules from biological mixtures using anion exchange.
Nelson, Robert J.; Hooper, Herbert H.; Hauser, Alan K.; Singh, Sharat; Williams, Stephen J.; Sassi, Alexander P., Microfluidic apparatus and method for purification and processing.
Nelson Robert J. ; Hooper Herbert H. ; Hauser Alan K. ; Singh Sharat ; Williams Stephen J. ; Sassi Alexander P., Microfluidic method for nucleic acid purification and processing.
Robert J. Nelson ; Herbert H. Hooper ; Alan K. Hauser ; Sharat Singh ; Stephen J. Williams ; Alexander P. Sassi, Microfluidic method for nucleic acid purification and processing.
Brickus Romas A. (Brookline MA) Forbush Donald R. (Wollaston MA), Multicuvette centrifugal analyzer rotor with annular recessed optical window channel.
Bedingham, William; Ludowise, Peter D.; Robole, Barry W., Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector.
Haff Lawrence A. ; Picozza Enrico ; Bloch Will ; Ragusa Robert ; DiCesare Joseph ; Tracy David ; Saviano Paul ; Woudenberg Timothy M., Nucleic acid amplification reaction apparatus.
Chen Paul H.-D. (Boston MA) Findlay John B. (Rochester NY) Atwood Susan M. (Newark NY) Bergmeyer Lynn (Rochester NY), Nucleic acid material amplification and detection without washing.
Zanzucchi Peter J. (West Windsor Township NJ) Cherukuri Satyam C. (Cranbury NJ) McBride Sterling E. (Lawrence Township NJ) Judd Amrit K. (Belmont CA), Partitioned microelectronic device array.
DeVaney ; Jr. Mark J. (Rochester NY) Lercher John S. (Rochester NY) Wellman Jeffrey A. (Rochester NY), Processing apparatus for a chemical reaction pack.
Gomm, Cordell Kay; Luoma, II, Robert Paul; Arnquist, David Charles; Johnson, Ryan Patrick, Reagent and sample handling device for automatic testing system.
Warner Brian D. (Martinez CA) Nordell Benjamin T. (Belmont CA) Richardson Bruce J. (Los Gatos CA) El-Hage Amer (Menlo Park CA), Releasable multiwell plate cover.
Douglas A. Spicer ; Karin A. Hughes ; Robert J. Kaiser ; James E. Mahoney ; Amy L. Springer ; Mark L. Stolowitz ; Carl H. D. Weissman, Removal of dye-labeled dideoxy terminators from DNA sequencing reactions.
Spicer, Douglas A.; Hughes, Karin A.; Kaiser, Robert J.; Mahoney, James E.; Springer, Amy L.; Stolowitz, Mark L.; Weissman, Carl H. D., Removal of dye-labeled dideoxy terminators from DNA sequencing reactions.
Kelton Arden A. (13561 Paysen Dr. Westminster CA 92683) Bell Michael L. (1357 Granada Way Corona CA 91720) Chung Roy A. (10094 Ellis Fountain Valley CA 92708), Rotary fluid manipulator.
Clark Frederick L. ; Moore Larry W. ; Walker Donny Ray ; Clemens John M ; Kanewske ; III William J. ; Smith B. Jane, Sample container segment assembly.
Bedingham, William; Carter, Chad J.; Harkins, Robert A.; Harms, Michael R.; Kokaisel, Christopher R.; North, Diane; Wood, Kenneth B., Sample processing devices and carriers.
Barker Stephen F. (La Mirada CA) Ricchio Samuel G. (Fullerton CA) Benton Glenn A. (Hesperia CA) Jackson Delbert D. (Placentia CA), Sample wheel for chemistry analyzers.
Smethers Rick T. (Milpitas CA) Leytes Lev J. (Palo Alto CA) Warner Brian D. (Martinez CA) Shadel Robert R. (San Francisco CA) Urdea Michael S. (Alamo CA), Self-contained assay assembly and apparatus.
Sellers,James M.; Taylor,Haydn B.; Kuba,Lawrence M., Slide cartridge and reagent test slides for use with a chemical analyzer, and chemical analyzer for same.
Reichler Allen S. (Owing Mills MD) Antol David J. (Baldwin MD) Lamos Michael L. (Westminster MD) Bourdelle Peter A. (Glen Rock PA) Hildebrand Scott D. (Red Lion PA), System for nucleic acid based diagnostic assay.
Devaney ; Jr. Mark J. (Eastman Kodak Co. Rochester NY 14650-2201) Wellman Jeffrey A. (Eastman Kodak Co. Rochester NY 14650-2201) Lercher John S. (Eastman Kodak Co. Rochester NY 14650-2201), Temperature control device and reaction vessel.
Krause Manfred (Viernheim DEX) Klein Bernd (Ludwigshafen DEX) Schindler Gerhard (Grndstadt DEX) Schfer Peter (Ludwigshafen DEX) Ntzel Siegfried (Wilhelmsfeld DEX), Test carrier for analysis of fluids.
Atwood John G. (West Redding CT) Mossa Albert C. (Trumbull CT) Goven Lisa M. (Bridgeport CT) Williams Fenton (Brookfield CT) Woudenberg Timothy M. (Bethel CT) Margoulies Marcel (Scarsdale NY) Ragusa , Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control.
Atwood John G. (West Redding CT) Mossa Albert C. (Trumbull CT) Goven Lisa M. (Bridgeport CT) Williams Fenton (Brookfield CT) Woudenberg Timothy M. (Bethel CT) Margulies Marcel (Scarsdale NY) Ragusa R, Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control.
Wasson, James; Frankovich, John Kent; Holmes, Elizabeth A.; Smith, Timothy; Chen, Michael; Young, Daniel, Systems and methods for fluid and component handling.
Holmes, Elizabeth A.; Pangarkar, Chinmay; Anekal, Samartha; Frankovich, John K.; Chen, Michael; Smith, Timothy, Systems and methods for multi-analysis.
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