(−)-Epigallocatechin gallate derivatives for inhibiting proteasome
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C07D-311/00
A61K-031/25
C07D-311/62
출원번호
US-0229315
(2014-03-28)
등록번호
US-9169230
(2015-10-27)
발명자
/ 주소
Chan, Tak-Hang
Lam, Wai-Har
Chow, Larry Ming-Cheung
Dou, Qing Ping
Kuhn, Deborah Joyce
Kazi, Aslamuzzaman
Wan, Sheng Biao
Landis-Piwowar, Kristin R.
출원인 / 주소
THE HONG KONG POLYTECHNIC UNIVERSITY
대리인 / 주소
Buchanan Ingersoll & Rooney PC
인용정보
피인용 횟수 :
0인용 특허 :
3
초록
A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:
대표청구항▼
1. A method for treating a cancer, the method comprising administering an effective amount of a compound having the formula: wherein R5 is —H; andwherein the formula satisfies one of the following conditions (1) or (2):(1) each of R11, R12, R13, R21, R22, and R2 is an acetate group, and each of R3
1. A method for treating a cancer, the method comprising administering an effective amount of a compound having the formula: wherein R5 is —H; andwherein the formula satisfies one of the following conditions (1) or (2):(1) each of R11, R12, R13, R21, R22, and R2 is an acetate group, and each of R3 and R4 is —H;(2) each of R11, R12, R13, R21, and R22 is an acetate group, each of R2 and R4 is an acetate group, and R3 is —H. 2. The method of claim 1, wherein each of R11, R12, R13, R21, and R22 is an acetate group, R2 is an acetate group, and each of R3 and R4 is —H. 3. The method of claim 1, wherein each of R11, R12, R13, R21, and R22 is an acetate group, each of R2 and R4 is an acetate group, and R3 is —H. 4. A compound having the formula: wherein R5 is —H; andwherein the formula satisfies one of the following conditions (1) or (2):(1) each of R11, R12, R13, R21, R22, and R2 is an acetate group, and each of R3 and R4 is —H;(2) each of R11, R12, R13, R21, R22 is an acetate group, each of R2 and R4 is an acetate group, and R3 is —H. 5. The compound of claim 4, wherein each of R11, R12, R13, R21, and R22 is an acetate group, R2 is an acetate group, and each of R3 and R4 is —H. 6. The compound of claim 4, wherein each of R11, R12, R13, R21, and R22 is an acetate group, each of R2 and R4 is an acetate group, and R3 is —H. 7. The method of claim 1, wherein the cancer is a hematological cancer. 8. The method of claim 2, wherein the cancer is a hematological cancer. 9. The method of claim 3, wherein the cancer is a hematological cancer.
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이 특허에 인용된 특허 (3)
Chan, Tak Hang; Lam, Wai Har; Chow, Larry Ming Cheung; Dou, Qing Ping; Kuhn, Deborah Joyce; Kazi, Aslamuzzaman, (-)-Epigallocatechin gallate derivatives for inhibiting proteasome.
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