A laboratory animal pharmaceutical testing device comprising a substantially closed animal holding cell, having a dry powder generator communicating through a wall of the cell, and one or more filtered inlets for permitting exchange of fresh air into the cell.
대표청구항▼
1. A laboratory animal pharmaceutical testing device comprising a substantially closed animal holding cell sized to accommodate more than one animal at the same time; a vibratory dry powder generator communicating through an opening in a wall of the cell for introduction of a medication into the cel
1. A laboratory animal pharmaceutical testing device comprising a substantially closed animal holding cell sized to accommodate more than one animal at the same time; a vibratory dry powder generator communicating through an opening in a wall of the cell for introduction of a medication into the cell;one or more filtered inlets for permitting exchange of fresh air into the cell; anda conduit including a fan through which air and medication in the cell is recirculated out of the cell and returned to the cell;wherein the opening in the wall of the cell through which the medication is introduced into the cell is located in an upper part of the cell so that the bulk of the medication will be inhaled by the animals before the medication settles in the bottom of the cell, andwherein said cell and conduit are sealed such that air and nebulized medication inside the cell or conduit are not able to exit from the cell and conduit to the atmosphere outside of the cell and conduit. 2. The device of claim 1, wherein the vibratory dry powder generator comprises a piezo vibrator. 3. The device of claim 1, further comprising a microprocessor and control for the nebulizer. 4. The device of claim 1, further comprising a timer for controlling the nebulizer. 5. The device of claim 1, further comprising an electronic controller for controlling airflow equipment connected to the animal holding cell. 6. The device of claim 1, wherein a dose delivered amount is determined by the number of timed or pulsed activations of the nebulizer. 7. The device of claim 1, further comprising visual, audible or tactile feedbacks to the equipment operator indicating a status of the device and of dosing. 8. A device for delivering dry powder medication to laboratory animals, comprising an aerosol chamber into which an aerosolized medication may be introduced; an animal holding cell including a mask portion, wherein said animal holding cell is sized to restrain an animal's mouth and nose in position within the cell and wherein the mask portion includes a mouthpiece or nasal cannula;an outlet for said chamber in communication with said animal holding cell, wherein said outlet is at least partially surrounded by said mask portion;a nebulizer for aerosolizing a medication and introducing the medication into the chamber;a sensor for sensing an inhalation and/or exhalation cycle of the animal, and a controller for turning the nebulizer on and off synchronized to tidal breathing of the animal, andan exhaust fan, a filter, a scrubber and a dryer in communication with the aerosol chamber and also in communication with atmospheric air outside the device, wherein air carrying the aerosolized medication passes through the exhaust fan, filter, scrubber and dryer before being vented into the outside atmospheric air so that loss of medication from the device is minimized; and a conduit including the fan through which air and medication in the cell is recirculated out of the cell and returned to the cell. 9. The device of claim 8, further comprising a microprocessor and control for the nebulizer. 10. The device of claim 8, further comprising a timer for controlling the nebulizer. 11. The device of claim 8, further comprising an electronic controller for controlling airflow equipment connected to the chamber. 12. The device of claim 8, wherein a dose delivered amount is determined by the number of timed or pulsed activations of the nebulizer. 13. The device of claim 8, further comprising visual, audible or tactile feedbacks to the equipment operator indicating the status of the device and of dosing. 14. The device of claim 8, wherein inhalation and/or exhalation is sensed using sensors selected from the group consisting of flow sensors, pressure sensors, temperature sensors, gas sensors and chest straps. 15. A laboratory animal pharmaceutical testing device comprising at least one animal holding chamber sized to restrain a laboratory animal with its mouth and nose held in position; a first chamber and a second chamber, wherein said first chamber and said second chamber are each in communication with said holding chamber;a pharmaceutical nebulizer communicating through said first chamber to said holding chamber;a controller for controlling the nebulizer;a sensor for sensing an inhalation and/or exhalation cycle of the animal, and a controller for turning the nebulizer on and off synchronized to tidal breathing of the animal;a pressurized air source in communication with the nebulizer and capable of producing a positive pressure air stream to deliver a medication from the nebulizer to the mask or nasal cannula section; andan exhaust fan, a filter, a scrubber and a dryer in communication with an outlet in said second chamber and also in communication with atmospheric air outside the device, wherein air carrying the medication passes through the exhaust fan, filter, scrubber and dryer before being vented into the outside atmospheric air so that loss of medication from the device is minimized; and a conduit including the fan through which air and medication in the cell is recirculated out of the at least one animal holding chamber and returned to the cell. 16. The device of claim 15, wherein the nebulizer comprises a vibratory dry powder inhaler. 17. The device of claim 16, wherein the vibratory dry powder inhaler comprises a piezo vibrator. 18. The device of claim 15, further comprising a microprocessor and control for the nebulizer. 19. The device of claim 15, wherein the controller comprises a microprocessor. 20. The device of claim 15, further comprising an electronic controller for controlling airflow equipment connected to the nebulizer. 21. The device of claim 15, wherein a dose delivered amount is determined by the number of timed or pulsed activations of the nebulizer. 22. The device of claim 15, further comprising visual, audible or tactile feedbacks to the equipment operator indicating the status of the device and of dosing. 23. The device of claim 15, wherein inhalation and/or exhalation is sensed using sensors selected from the group consisting of flow sensors, pressure sensors, temperature sensors, gas sensors and chest straps.
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