Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61L-015/32
A61K-031/385
A61K-033/18
A61K-033/38
A61K-038/17
A61K-045/06
A61M-001/00
A61L-015/44
A61L-026/00
출원번호
US-0068961
(2013-10-31)
등록번호
US-9186431
(2015-11-17)
발명자
/ 주소
Zimnitsky, Dmitry
Finkbiner, Jenny
Sanders, Blane
출원인 / 주소
KCI Licensing, Inc.
인용정보
피인용 횟수 :
0인용 특허 :
87
초록▼
According to an illustrative embodiment a method to promote healing of a wound is provided comprising contacting the wound with a biologically active composition comprising a lipoic acid derivative and gelatin. In another embodiment a topical composition is provided, which can be formulated as a hom
According to an illustrative embodiment a method to promote healing of a wound is provided comprising contacting the wound with a biologically active composition comprising a lipoic acid derivative and gelatin. In another embodiment a topical composition is provided, which can be formulated as a homogenous mixture, such as a spray, mist, aerosol, lotion, cream, solution, oil, gel, ointment, paste, emulsion or suspension or applied on a carrier material, such as a bandage, gauze, foam, sponge, hydrogel, hydrocolloid, hydrofiber, occlusive dressing, adhesive composition or scaffold. Methods for producing such a topical composition and carrier material with the topical composition applied thereto are also disclosed.
대표청구항▼
1. A method for promoting wound healing comprising contacting a wound site with a topical composition comprising an effective amount of a lipoic acid derivative and an effective amount of a sacrificial proteolytic enzyme substrate, wherein the topical composition is applied to a wound dressing capab
1. A method for promoting wound healing comprising contacting a wound site with a topical composition comprising an effective amount of a lipoic acid derivative and an effective amount of a sacrificial proteolytic enzyme substrate, wherein the topical composition is applied to a wound dressing capable of distributing reduced pressure to the wound site. 2. The method of claim 1, wherein the effective amount of a lipoic acid derivative and the effective amount of a sacrificial proteolytic enzyme substrate function to reduce inflammation and promote wound healing. 3. The method of claim 1, wherein the lipoic acid derivative and the sacrificial proteolytic enzyme substrate form a homogenous mixture. 4. The method of claim 1, wherein the sacrificial proteolytic enzyme substrate comprises gelatin. 5. The method of claim 1, wherein the lipoic acid derivative comprises the structure: wherein n1 and n2 are, independently, C1-C10 alkyl; andR1 is H, C1-C10 alkyl, C6-C14 aryl, an alkyl ammonium or a protonated amino acid. 6. The method of claim 1, wherein the lipoic acid derivative is a dihydrolipoic acid comprising the structure: wherein n1 and n2 are, independently, C1-C10 alkyl;R1 is H, C1-C10 alkyl, C6-C14 aryl, an alkyl ammonium or a protonated amino acid; andR2 is H, C1-C10 alkyl or C6-C14 aryl. 7. The method of claim 1, wherein the lipoic acid derivative is provided as a pharmaceutically acceptable salt. 8. The method of claim 1, wherein the lipoic acid derivative is alpha-lipoic acid or sodium lipoate. 9. The method of claim 1, wherein the topical composition comprises 0.1% to 5% or 0.01% to 10% w/w lipoic acid derivative. 10. The method of claim 1, wherein the topical composition comprises 0.1% to 25% w/w of a sacrificial proteolytic enzyme substrate. 11. The method of claim 1, wherein the topical composition further comprises one or more of an antimicrobial agent, a growth factor, a proteinase inhibitor, a chelating agent or a preservative. 12. The method of claim 11, wherein the antimicrobial agent is at least one of non-ionic silver, polyhexamethylene biguanide, chlorhexidine, benzalconium chloride or triclosan. 13. The method of claim 11, wherein the chelating agent is ethylenediaminetetraacetic acid. 14. The method of claim 1, wherein the topical composition is in the form of a spray, mist, aerosol, lotion, cream, solution, oil, gel, ointment, paste, emulsion or suspension.
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이 특허에 인용된 특허 (87)
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