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Systems and methods for characterizing spatial distortions in location data determined by an imaging system, for example as employed in imaged guided therapy. A three dimensional phantom is custom formed for a desired imaging space of a given imaging system. The phantom includes a large plurality of

Systems and methods for characterizing spatial distortions in location data determined by an imaging system, for example as employed in imaged guided therapy. A three dimensional phantom is custom formed for a desired imaging space of a given imaging system. The phantom includes a large plurality of control points fixed rigidly in space to a high degree of known accuracy. The phantom is fixed to a stereotactic frame defining a known calibrated reference or zero and imaged. An algorithm customized for the phantom determines the spatial locations of the control points. A comparison is made between the known and the determined spatial locations for at least a subset of the control points. The comparison results in indicia for any determined spatial distortions observed. The raw image data can be manipulated to compensate for any spatial distortion. The control points can have fixed locations known to an accuracy of 100 μm or better. The algorithm can determine an initial estimate for the detected location of a control point accurate to .+−.0.5 pixel or better.

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1. A method for characterizing spatial distortion of a medical imaging system, the method comprising: estimating a contour and dimensions of a desired target volume;determining a desired coordinate system;determining a volumetric arrangement and uniform spacing of a plurality of control points in a

1. A method for characterizing spatial distortion of a medical imaging system, the method comprising: estimating a contour and dimensions of a desired target volume;determining a desired coordinate system;determining a volumetric arrangement and uniform spacing of a plurality of control points in a three-dimensional space, wherein the desired arrangement and spacing is matched to the contour, dimensions, and coordinate system such that the control points are interspersed within and throughout the entire target volume;providing a substantially rigid three-dimensional phantom that is matched to the determined volumetric arrangement and uniform spacing of the plurality of control points in the three-dimensional space and that is also configured to rigidly fix the control points in an interspersed manner throughout its substantially rigid structure;fixing the phantom with respect to a stereotactic frame such that the plurality of control points defines a corresponding plurality of first known spatial locations;imaging the phantom;determining second measured spatial locations based on the imaging;comparing at least a selected volumetric subset of the first known spatial locations with corresponding second measured spatial locations; andcalculating indicia of any indicated volumetric spatial distortion between the first known spatial locations and the corresponding second measured spatial locations. 2. The method of claim 1, wherein the estimating the contour and dimensions of the desired target volume is performed to match a portion of a living body. 3. The method of claim 1, wherein the three dimensional phantom is fabricated at least in part via a rapid prototyping process. 4. The method of claim 3, wherein the rapid prototyping process comprises selective laser sintering. 5. The method of claim 1, further comprising operating on the second measured spatial locations so as to create a corrected set of measured spatial locations having reduced spatial distortion with respect to the first known spatial locations. 6. A system for characterizing spatial errors in a medical imaging system, the system comprising: a substantially rigid three-dimensional phantom having a plurality of control points, wherein the control points are interspersed uniformly within and throughout a three-dimensional volume and are substantially rigidly fixed with respect to each other;a fixture rigidly connectable to the phantom and connectable to a stereotactic frame of a medical imaging system such that the control points can be positioned to occupy first known spatial locations within an imaging space of the imaging system; andan analysis module in communication with the imaging system so as to obtain data indicative of second measured spatial locations of at least a volumetric subset of the plurality of control points as determined by the imaging system and wherein the analysis module compares the first known spatial locations with the corresponding second measured spatial locations and calculates an indicia of any determined variation between the first known spatial locations and the corresponding second measured spatial locations for at least the volumetric subset of the plurality of control points. 7. The system of claim 6, further comprising a chamber configured to enclose the phantom. 8. The system of claim 7, wherein the chamber is configured to enclose the phantom in a substantially fluid tight manner and wherein the chamber is further provided with contrast material. 9. The system of claim 6, wherein the analysis module further operates on the second measured spatial locations so as to create a corrected set of measured spatial locations having reduced spatial distortion with respect to the first known spatial locations. 10. The system of claim 6, wherein the plurality of control points are distributed in a substantially uniform spacing within a sub-volume of the phantom corresponding to a planned treatment volume. 11. The system of claim 6, wherein the phantom is custom matched to the imaging system. 12. The system of claim 11, wherein the phantom is custom matched to at least one specific imaging volume of the imaging system. 13. An apparatus for characterizing volumetric spatial distortion of a medical imaging system, the apparatus comprising: a substantially rigid volumetric phantom comprising: a three-dimensional volume;an outer perimeter generally enclosing the three-dimensional volume;a plurality of control points that are interspersed uniformly within the outer perimeter and throughout the three-dimensional volume and that are substantially rigidly fixed with respect to each other and with respect to the outer perimeter;a fixture configured to rigidly fix the phantom to a spatial reference point such that the control points occupy known spatial locations within an imaging space of the imaging system; andan analysis module configured to: communicate with the imaging system to obtain measured spatial locations of at least a volumetric subset of the plurality of control points as determined by the imaging system;compare the known spatial locations with the corresponding measured spatial locations as determined by the imaging system; andcalculate any determined variation between the known spatial locations and the corresponding measured spatial locations for at least the volumetric subset of the plurality of control points. 14. The apparatus of claim 13, further configured to use indicia of the determined variation to apply a correction factor, thereby correcting for volumetric spatial distortion of the imaging system. 15. The apparatus of claim 13, wherein the plurality of control points comprise intersections of elongate rigid material. 16. The apparatus of claim 13, wherein the three-dimensional volume has numerous control points volumetrically spaced and thereby configured to be imaged from any of a plurality of angles, the angles corresponding to treatment angles. 17. The apparatus of claim 16, wherein the control points are spaced and configured to allow for effective calibration of a proton beam therapy system having high resolution treatment capabilities. 18. The apparatus of claim 13, wherein the outer perimeter is generally cylindrical, the control points are interspersed in bands exhibiting cylindrical symmetry, and bands of successively wider radius have control points that are spaced farther from each other than in the previous band. 19. The apparatus of claim 13, wherein the control points have one point to point spacing in a target subvolume and a different point to point spacing outside the target subvolume but still within the three-dimensional volume and the outer perimeter thereof.