초록 ▼

This invention relates to methods for producing a composite bone graft material that can regenerate bony defects in the body. The invention further relates to methods that allow for the production of bioactive glass particles used in the composite that have been surface treated to allow for the prod

This invention relates to methods for producing a composite bone graft material that can regenerate bony defects in the body. The invention further relates to methods that allow for the production of bioactive glass particles used in the composite that have been surface treated to allow for the production of a highly porous composite that can hold significant amounts of body fluid or other molecules that will aid in the regenerative process. The method of surface treatment allows for the manufacture of a suitable implantable composite while retaining the unique osteostimulative properties that are associated with bioactive glass particles.

대표청구항 ▼

1. A bone regenerative composition including 2-20% collagen and 80-98% bioactive glass, wherein the composition is free from calcium phosphate. 2. The bone regenerative composition of claim 1, wherein the bioactive glass has a porosity of up to 90%. 3. The bone regenerative composition of claim 1, w

1. A bone regenerative composition including 2-20% collagen and 80-98% bioactive glass, wherein the composition is free from calcium phosphate. 2. The bone regenerative composition of claim 1, wherein the bioactive glass has a porosity of up to 90%. 3. The bone regenerative composition of claim 1, wherein the bioactive glass has pores ranging from about 10 to about 5100 microns. 4. The bone regenerative composition of claim 1, wherein the bioactive glass has average pore size of 100 microns plus or minus 50 microns. 5. The bone regenerative composition of claim 1, wherein the bioactive glass has average pore size of 200 microns plus or minus 50 microns. 6. The bone regenerative composition of claim 1, wherein the bioactive glass has average pore size of 300 microns plus or minus 50 microns. 7. The bone regenerative composition of claim 1, wherein the bioactive glass has average pore size of 400 microns plus or minus 50 microns. 8. The bone regenerative composition of claim 1, wherein the bioactive glass has average pore size of 500 microns plus or minus 50 microns. 9. The bone regenerative composition of claim 1, wherein the bioactive glass has average pore size of 600 microns plus or minus 50 microns. 10. The bone regenerative composition of claim 1, wherein the bioactive glass has average pore size of 700 microns plus or minus 50 microns. 11. The bone regenerative composition of claim 1, including 3-10% collagen and 90-97% bioactive glass. 12. The bone regenerative composition of claim 1, further comprising an extracellular matrix molecule selected from the group consisting of integrins, fibronectin, vitronectin, osteopontin, bone sialoprotein thrombospondin, and fibrinogen, or a homo or copolymer of glycolides, acrylates, lactic acids, and caprolactone. 13. The bone regenerative composition of claim 1, wherein said composition is crosslinked. 14. The bone regenerative composition of claim 1, wherein said composition is freeze-dried. 15. The bone regenerative composition of claim 1, including 3% collagen and 97% bioactive glass. 16. The bone regenerative composition of claim 15, wherein said composition is crosslinked. 17. The bone regenerative composition of claim 15, wherein said composition is freeze-dried.