System and kit for delivering collagen bioglass composite bone grafting materials for regenerating hard tissues
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-005/145
A61K-033/42
A61K-038/39
A61K-045/06
A61L-027/10
A61L-027/24
A61L-027/46
A61L-027/56
A61L-027/44
출원번호
US-0572349
(2014-12-16)
등록번호
US-9199032
(2015-12-01)
발명자
/ 주소
McBride, Dennis
Clark, Joshua P.
Davis, Richard
Pomrink, Gregory J.
Tosun, Zehra
Greenspan, David C.
출원인 / 주소
NOVABONE PRODUCTS, LLC
대리인 / 주소
Brinks Gilson & Lione
인용정보
피인용 횟수 :
1인용 특허 :
40
초록▼
Methods for producing a composite bone graft material that can regenerate bony defects in the body are provided. Also, methods, kits and delivery systems for a minimally invasive delivery of a composition for regenerating bone at or near the site of a bony defect that include, the composition for re
Methods for producing a composite bone graft material that can regenerate bony defects in the body are provided. Also, methods, kits and delivery systems for a minimally invasive delivery of a composition for regenerating bone at or near the site of a bony defect that include, the composition for regenerating bone comprising collagen and bioactive glass are provided.
대표청구항▼
1. A kit for a minimally invasive delivery of a composition for regenerating bone at or near the site of a bony defect, the kit comprising: i. at least one tube comprising the composition for regenerating bone comprising about 2-60% collagen and about 40-98% bioactive glass, wherein the composition
1. A kit for a minimally invasive delivery of a composition for regenerating bone at or near the site of a bony defect, the kit comprising: i. at least one tube comprising the composition for regenerating bone comprising about 2-60% collagen and about 40-98% bioactive glass, wherein the composition is free from calcium phosphate, and wherein the tube is capped or sealed when not in use;ii. a dispensing gun;iii. an adapter;iv. a plunger; andv. optionally, a dispensing tip. 2. The kit of claim 1, wherein the components of the kit are snap fit into a tray and a retainer is placed to maintain position of the components in the tray. 3. The kit of claim 2, wherein the tray holds up to four tubes comprising the composition. 4. The kit of claim 1, further comprising a syringe. 5. The kit of claim 1, further comprising a “Y” connector, tube connector, or an aspiration needle, or a combination thereof. 6. The kit of claim 1, wherein the bioactive glass has a porosity of up to 90%. 7. The kit of claim 1, wherein the bioactive glass has pores ranging from about 1 to about 5100 microns. 8. The kit of claim 1, wherein the bioactive glass has average pore size of <50 microns. 9. The kit of claim 1, wherein the bioactive glass has average pore size of 100 microns plus or minus 50 microns. 10. The kit of claim 1, wherein the bioactive glass has average pore size of 200 microns plus or minus 50 microns. 11. The kit of claim 1, wherein the bioactive glass has average pore size of 300 microns plus or minus 50 microns. 12. The kit of claim 1, wherein the bioactive glass has average pore size of 400 microns plus or minus 50 microns. 13. The kit of claim 1, wherein the bioactive glass has average pore size of 500 microns plus or minus 50 microns. 14. The kit of claim 1, wherein the bioactive glass has average pore size of 600 microns plus or minus 50 microns. 15. The kit of claim 1, wherein the bioactive glass has average pore size of 700 microns plus or minus 50 microns. 16. The kit of claim 1, wherein the composition comprises about 3-60% collagen and about 40-97% bioactive glass. 17. The kit of claim 1, wherein the composition comprises about 3-50% collagen and about 50-90% bioactive glass. 18. The kit of claim 1, wherein the composition further comprises an extracellular matrix molecule selected from the group consisting of integrins, fibronectin, vitronectin, osteopontin, bone sialoprotein thrombospondin, and fibrinogen, or a homo or copolymer of glycolides, acrylates, lactic acids, and caprolactone, and a combination thereof. 19. The kit of claim 1, wherein the composition is un-crosslinked. 20. The kit of claim 1, wherein the composition is crosslinked. 21. The kit of claim 1, wherein the composition is freeze-dried. 22. The kit of claim 1, wherein the bioactive glass have been pre-reacted in water, saline or a buffer. 23. The kit of claim 1, wherein the bioactive glass is not pre-reacted with a buffer. 24. The kit of claim 1, wherein the bioactive glass comprises 55-65% 1000-2000 um bioactive glass, 10-20% 90-710 um bioactive glass, and 10-20% 32-125 um bioactive glass. 25. The kit of claim 1, wherein the bioactive glass comprises 60% 1000-2000 um bioactive glass, 12.5% 90-710 um bioactive glass, and 12.5% 32-125 um bioactive glass. 26. The kit of claim 24, wherein the 1000-2000 um bioactive glass is porous. 27. The kit of claim 1, wherein the composition is in a form of a collagen bioactive glass composite. 28. The kit of claim 27, wherein the collagen bioactive glass composite is lyophilized. 29. The kit of claim 27, wherein the collagen and bioactive glass composite is lyophilized and crosslinked. 30. The kit of claim 1, wherein the composition is in a form of a mixture of: collagen in a granular, particulate, sphere or bead form, or a combination thereof, andbioactive glass in a granular, particulate, sphere or bead form, or a combination thereof. 31. The kit of claim 1, wherein the composition is in a granular, particulate, sphere or bead form, or a combination thereof, and comprises collagen and bioactive glass. 32. The kit of claim 1, wherein the composition further comprises at least one therapeutic agent, a signaling protein, glycosaminoglycan, or a combination thereof. 33. The kit of claim 1, wherein the bioactive glass is in a granular form, particulate form, matt form, fiber form, hemostatic sponge form, foam form, paste or putty form, or sphere or bead form, or a combination thereof. 34. The kit of claim 1, wherein the composition is pre-treated with water, saline, blood, bone marrow, a combination thereof, or other biocompatible substance to form a paste. 35. The kit of claim 1, wherein the bioactive glass comprises silicate based glasses. 36. The kit of claim 1, wherein the bioactive glass comprises borate based glasses. 37. A method for repairing or regenerating a bony defect comprising dispensing the composition for regenerating bone comprising about 2-60% collagen and about 40-98% bioactive glass at or near the site of the bony defect using the components of the kit of claim 1. 38. The method of claim 37, wherein the composition is moldable upon mixing with saline, blood, bone marrow, or other biocompatible fluid. 39. The method of claim 37, wherein the composition is pre-treated with water, saline, blood, bone marrow, a combination thereof, or other biocompatible substance to form a paste. 40. The method of claim 37, wherein the composition is in a form of a collagen bioactive glass composite. 41. The method of claim 40, wherein the collagen bioactive glass composite is lyophilized. 42. The method of claim 40, wherein the collagen and bioactive glass composite is lyophilized and crosslinked. 43. The method of claim 37, wherein the composition is in a form of a mixture of: collagen in a granular, particulate, sphere or bead form, or a combination thereof, andbioactive glass in a granular, particulate, sphere or bead form, or a combination thereof. 44. The method of claim 37, wherein the composition is in a granular, particulate, sphere or bead form, or a combination thereof, and comprises collagen and bioactive glass.
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