최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0917469 (2013-06-13) |
등록번호 | US-9204964 (2015-12-08) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 3 인용 특허 : 261 |
A device, kit and method may employ an implantable device (e.g., annuloplasty implant) and a tool to implant such. The implantable device is positionable in a cavity of a bodily organ (e.g., a heart) and operable to constrict a bodily orifice (e.g., a mitral valve). Tissue anchors are guided into pr
A device, kit and method may employ an implantable device (e.g., annuloplasty implant) and a tool to implant such. The implantable device is positionable in a cavity of a bodily organ (e.g., a heart) and operable to constrict a bodily orifice (e.g., a mitral valve). Tissue anchors are guided into precise position by an intravascularly deployed anchor guide frame and embedded in an annulus. Constriction of the orifice may be accomplished via a variety of structures, for example by cinching a flexible cable or anchored annuloplasty ring, the cable or ring attached to the tissue anchors. The annuloplasty ring may be delivered in a generally elongated configuration, and implanted in an anchored generally arch, arcuate or annular configuration. Such may move a posterior leaflet anteriorly and an anterior leaflet posteriorly, improving leaflet coaptation to eliminate mitral regurgitation.
1. An implant kit comprising: a plurality of tissue anchors comprising at least a first tissue anchor, a second tissue anchor and a third tissue anchor;a percutaneous delivery system operable to at least partially embed each of the tissue anchors into a respective location about a periphery of an or
1. An implant kit comprising: a plurality of tissue anchors comprising at least a first tissue anchor, a second tissue anchor and a third tissue anchor;a percutaneous delivery system operable to at least partially embed each of the tissue anchors into a respective location about a periphery of an orifice in a tissue within a body during an implant procedure in which a location of the embedded third tissue anchor is laterally offset by a first distance from a first axis, the first axis extending between a location of the embedded first tissue anchor and a location of the embedded second tissue anchor;an implant member reconfigurable between a delivery configuration in which the implant member is manipulable to a size and dimension to be deliverable percutaneously to the tissue within the body, and an implantable configuration in which the implant member forms a structure sufficiently rigid to affect a shape of the orifice in the tissue, the implant member further comprising a plurality of guide line receivers and a plurality of tissue anchor receivers, each of the tissue anchor receivers positioned to physically matingly couple directly with a respective one of the embedded tissue anchors rather than with any guide lines and each of the tissue anchor receivers being positioned in the implant member between a respective one of the guide line receivers and an embedded portion of a respective one of the embedded tissue anchors in a state in which the respective one of the embedded tissue anchors is physically coupled to the tissue anchor receiver, the plurality of tissue anchor receivers comprising at least a first tissue anchor receiver corresponding to the first tissue anchor, a second tissue anchor receiver corresponding to the second tissue anchor, and a third tissue anchor receiver corresponding to the third tissue anchor, wherein a location of the third tissue anchor receiver on the implant member in the implantable configuration is laterally offset by a second distance from a second axis, the second axis extending between a location of the first tissue anchor receiver on the implant member and a location of the second tissue anchor receiver on the implant member, wherein the second distance is smaller than the first distance; anda plurality of implant guide lines that in use during the implant procedure are respectively received by the guide line receivers and provide a physical path for the implant member to the embedded tissue anchors. 2. The implant kit of claim 1 wherein the implant member comprises a plurality of segments physically coupled to one another, the segments being articuable with respect to one another as the implant member is moved between the deliverable configuration and the implantable configuration. 3. The implant kit of claim 2 wherein the implant member comprises a number of hinges that physically couple each of the segments to at least one other of the segments. 4. The implant kit of claim 3 wherein the implant member comprises a number of stops configured to increase a torsional stiffness of each of the hinges when each of the segments pivots by a defined amount with respect to another of the segments. 5. The implant kit of claim 2 wherein the implant member comprises a number of flexure joints that physically couple each of the segments to at least one other of the segments. 6. The implant kit of claim 5 wherein the implant member comprises a number of stops configured to increase a bending stiffness of each of the flexure joints when each of the segments flexes by a defined amount with respect to another of the segments. 7. The implant kit of claim 2 wherein the implant member comprises a number of stops configured to restrain articulation between the coupled segments. 8. The implant kit of claim 1 wherein each of the tissue anchors comprises at least one barb. 9. The implant kit of claim 1 wherein each of the tissue anchors is a helical tissue anchor. 10. The implant kit of claim 1 wherein each of the tissue anchors is a grapple tissue anchor, each grapple tissue anchor comprising at least two prongs pivotally coupled to each other, and each of the two prongs having a tip shaped to pierce the tissue. 11. The implant kit of claim 1 wherein the implant member has at least three guide line receivers that each ride on respective ones of the guide lines, wherein a circumference defined by a circle passing through at least three locations of the at least three guide line receivers on the implant member in the implantable configuration is smaller than a circumference defined by a circle passing through the respective locations of the embedded first, second and third tissue anchors prior to a physical mating coupling directly between each of the embedded first, second and third tissue anchors and respective ones of the first, second and third tissue anchor receivers. 12. The implant kit of claim 1, wherein the implant member is reconfigured into the implantable configuration during physical matingly coupling directly with a respective one of the embedded tissue anchors. 13. The implant kit of claim 1 wherein the embedded tissue anchors apply tension to implant member in the implantable configuration when each of the tissue anchor receivers is physically matingly coupled directly with a respective one of the embedded tissue anchors. 14. The implant kit of claim 1 wherein each of the tissue anchor receivers is positioned to physically matingly couple directly with a respective one of previously-embedded tissue anchors in the implantable configuration. 15. The implant kit of claim 1 wherein the plurality of tissue anchor receivers each include sidewalls that extend through the implant member. 16. The implant kit of claim 1 wherein the plurality of tissue anchors each include a coupler, the couplers being received by the implant member in the implantable configuration. 17. The implant kit of claim 16 wherein the couplers each include a seat including a first component coupled to a first member of a corresponding tissue anchor and a second component coupled to a second member of the corresponding tissue anchor, the first and second members of the corresponding tissue anchor configured to be at least partially embedded in the tissue. 18. The implant kit of claim 16 wherein the couplers each include a seat including a first component and a second component, the first and second components including tapered surfaces configured to mate with a tapered surface of a tissue anchor receiver. 19. An implant kit, comprising: an implant member configured to affect a shape of an orifice in tissue within a body during an implant procedure, a portion of the implant member having a variable bending stiffness in at least one dimensional plane, the implant member comprising a first end, a second end and a plurality of guide line receivers positioned between the first end and the second end along the implant member, the implant member configured to be bendable between a first configuration in which implant member has an elongated shape and a second configuration in which the implant has an arcuate shape, the first end being spaced apart from the second end by a greater distance when the implant member is in the first configuration than when the implant member is in the second configuration, and the portion of the implant member having a reduced bending stiffness in the at least one dimensional plane when the implant member is in first configuration and an increased bending stiffness in the at least one dimensional plane when the implant member is in the second configuration;a plurality of tissue anchors configured to be at least partially embedded into tissue at respective locations about the orifice in the tissue within the body;a plurality of guide lines, each of the guide lines sized to be received by a respective one of the guide line receivers and a respective one of the tissue anchors, each of at least one of the guide lines being configured to receive a tensile force sufficient to move a portion of the tissue into which a respective tissue anchor is embedded towards the implant member in the second configuration; anda plurality of tissue anchor receivers positioned along the implant member between the first end and the second end, each of the tissue anchor receivers positioned to physically matingly couple directly with a respective one of the embedded tissue anchors rather than with any guide lines and each of the tissue anchor receivers being positioned in the implant member between a respective one of the guide line receivers and an embedded portion of a respective one of the embedded tissue anchors in a state in which the respective one of the embedded tissue anchors is physically coupled to the tissue anchor receiver, and wherein each of the at least one of the guide lines is configured to receive a tensile force sufficient to move the portion of the tissue to a position where the respective tissue anchor embedded into the portion of the tissue is physically received by a respective tissue anchor receiver when the implant member in the second configuration. 20. The implant kit of claim 19 wherein the implant member comprises a plurality of segments physically coupled to one another, the segments being articuable with respect to one another to provide the reduced bending stiffness in the at least one dimensional plane when the implant member is in the first configuration. 21. The implant kit of claim 20 wherein the implant member comprises a number of hinges that physically couple each of the segments to at least one other of the segments. 22. The implant kit of the claim 21 wherein the implant member comprises a number of stops configured to increase a torsional stiffness of each of the hinges when each of the segments pivots by a defined amount with respect to another of the segments to provide the increased bending stiffness in the at least one dimensional plane when the implant member is in the second configuration. 23. The implant kit of claim 20 wherein the implant member comprises a number of flexure joints that physically couple each of the segments to at least one other of the segments. 24. The implant kit of claim 23 wherein the implant member comprises a number of stops configured to provide the increased bending stiffness in the at least one dimensional plane when the implant member is in the second configuration. 25. The implant kit of claim 20 wherein the implant member comprises a number of stops configured to restrain articulation between the coupled segments to provide the increased bending stiffness in the at least one dimensional plane when the implant member is in the second configuration. 26. The implant kit of claim 25 wherein the embedded tissue anchors apply tension to implant member in the second configuration when each of the tissue anchor receivers is physically matingly coupled directly with a respective one of the embedded tissue anchors. 27. The implant kit of claim 26 wherein the applied tension is sufficient to restrain disengagement of each of the coupled segments with an associated one of the stops. 28. The implant kit of claim 26 wherein the applied tension is sufficient to flex at least one of segments while each of the at least one of the segments is engaged with an associated one of the stops. 29. The implant kit of claim 19 wherein each of the tissue anchors comprises at least one piercing element configured for piercing the tissue. 30. The implant kit of claim 19 wherein each of the tissue anchors is a helical tissue anchor. 31. The implant kit of claim 19 wherein each of the tissue anchors is a grapple tissue anchor, each grapple tissue anchor comprising at least two prongs pivotally coupled to each other, and each of the two prongs having a tip shaped to pierce the tissue. 32. The implant kit of claim 19 wherein the plurality of guide line receivers comprise at least three guide line receivers, a circumference defined by a circle passing through at least three locations of the at least three guide line receivers on the implant member in the second configuration being smaller than a circumference defined by a circle passing through at least three locations of their respective embedded tissue anchors about the orifice in the tissue prior to a physical coupling between any of the tissue anchor receivers and their respective embedded tissue anchors. 33. The implant kit of claim 19 wherein the implant member in the first configuration is manipulable to a size and dimension to be deliverable via a catheter. 34. The implant kit of claim 19, wherein the portion of the implant member has a substantially equal bending stiffness in each of a plurality of directions in the at least one dimensional plane when the implant member is in the first configuration and the portion of the implant member has a substantially unequally bending stiffness in each of the plurality of directions in the at least one dimensional plane when the implant member is in the second configuration. 35. The implant kit of claim 19, wherein the implant member is moved to the second configuration during physical matingly coupling directly with a respective one of the embedded tissue anchors. 36. The implant kit of claim 19 wherein the embedded tissue anchors apply tension to implant member in the second configuration when each of the tissue anchor receivers is physically matingly coupled directly with a respective one of the embedded tissue anchors. 37. An implant kit, comprising: a plurality of tissue anchors configured to be at least partially embedded into tissue at respective locations about an orifice in the tissue during an implant procedure;an implant member having a plurality of segments physically coupled to one another, a number of guide line receivers, and at least three tissue anchor receivers, each of the tissue anchor receivers physically matingly coupleable directly to a respective one of the plurality of embedded tissue anchors, and each of the tissue anchor receivers being positioned in the implant member between a respective one of the guide line receivers and an embedded portion of a respective on of the embedded tissue anchors in a state in which the respective one of the embedded tissue anchors is physically coupled to the tissue anchor receiver, in a delivery configuration the segments being articulable with respect to one another by a respective articulation joint such that the implant member is manipulable to a size and dimension to be deliverable via a catheter and in a deployed configuration the segments form a structure sufficiently rigid to affect a shape of the orifice in the tissue when the implant member is positioned to physically couple with the embedded tissue anchors; anda plurality of implant guide lines that in use during the implant procedure are respectively received by the guide line receivers and provide a physical path for the implant member to respective ones of the embedded tissue anchors, the implant member moveable along the physical path to a position where the implant member is directly secured to the embedded tissue anchors under tension in the deployed configuration. 38. The implant kit of claim 37 wherein the tissue anchors and respective ones of the guide lines are integral structures comprised of at least one of a metal wire. 39. The implant kit of claim 37 wherein the tissue anchors and respective ones of the guide lines are unitary structures, each of the tissue anchors comprising at least one piercing element at a distal end of a respective one of the guide lines, wherein the at least one piercing element is configured to pierce the tissue. 40. The implant kit of claim 37 wherein the structure formed by the segments of the implant member has a C-shape profile. 41. The implant kit of claim 37, further comprising: an implant cross connector attachable across an open portion of the implant member such that when attached, the implant cross connector and the structure formed by the segments of the implant member have a D-shape profile. 42. The implant kit of claim 37 wherein the implant member has at least three guide line receivers, at least a first guide line receiver proximate a first end of the implant member, a second guide line receiver proximate a second end of the implant member, and a third guide line receiver positioned along the structure formed by the segments between the first and the second guide line receivers. 43. The implant kit of claim 37 wherein the respective articulation joint of the implant member comprises a number of hinges that physically couple each of the segments of the implant member to at least one other of the segments of the implant member. 44. The implant kit of claim 43 wherein the implant member comprises a number of stops configured to limit a travel of each of the segments of the implant member with respect to another of the segments of the implant member. 45. The implant kit of claim 43 wherein the implant member comprises a number of stops configured to increase a torsional stiffness of each of the hinges when each of the segments of the implant member pivots by a defined amount with respect to another of the segments of the implant member. 46. The implant kit of claim 37 wherein the respective articulation joint of the implant member comprises a number of flexure joints that physically couple each of the segments of the implant member to at least one other of the segments of the implant member. 47. The implant kit of claim 46 wherein the implant member comprises a number of stops configured to limit a travel of each of the segments of the implant member with respect to another of the segments of the implant member. 48. The implant kit of claim 46 wherein the implant member comprises a number of stops configured to increase a bending stiffness of each of the flexure joints when each of the segments of the implant member flexes by a defined amount with respect to another of the segments of the implant member. 49. The implant kit of claim 37, further comprising: an anchor guide frame having at least three anchor guide arms, wherein each of the tissue anchors is configured to be physically releasably guided by a respective one of the anchor guide arms of the anchor guide frame to a respective location on an annulus about the orifice in the tissue and embedded in the annulus at least proximate the respective locations. 50. The implant kit of claim 49 wherein the anchor guide arms each comprise an outer tube having at least a first outer tube lumen, and an inner tube having an inner tube lumen, the inner tube received in the first outer tube lumen of the outer tube for translational movement between a retracted position in which a distal end of the inner tube does not extend beyond a distal end of the first outer tube lumen and an extended position in which the distal end of the inner tube extends beyond the distal end of the first outer tube lumen, the inner tube lumen of the inner tube receiving a respective one of the guide lines for translation with respect thereto. 51. The implant kit of claim 50 wherein the distal end of the inner tube is in butting engagement with a portion of a respective one of the tissue anchors until the inner tube is withdrawn from the tissue anchor after the tissue anchor has been embedded in the tissue. 52. The implant kit of claim 50 wherein the tissue anchors each comprise at least one resilient barb, the at least one resilient barb protectively retained in the inner tube lumen of the inner tube until the inner tube is withdrawn from the tissue anchor after the tissue anchor has been embedded in the tissue. 53. The implant kit of claim 50 wherein the outer tube of each of the anchor guide arms further has a second outer tube lumen; and the anchor guide frame further comprises a plurality of arms, each of the arms received in the second outer tube lumen of a respective one of the anchor guide arms. 54. The implant kit of claim 37 wherein the implant member has at least three guide line receivers that each ride on respective ones of the guide lines, wherein a circumference defined by a circle passing through at least three locations of the at least three guide line receivers on the implant member in the deployed configuration is smaller than a circumference defined by a circle passing through at least three locations of the embedded tissue anchors in the tissue prior to a physical mating coupling directly between the implant member and the embedded tissue anchors. 55. The implant kit of claim 37 wherein the implant member has at least three guide line receivers that each ride on respective ones of the guide lines, wherein a circumference defined by a circle passing through at least three locations of the at least three guide line receivers on the implant member in the deployed configuration is smaller than a circumference of an annulus of the orifice in the tissue prior to a physical mating coupling directly between the implant member and the embedded tissue anchors. 56. The implant kit of claim 37 wherein a circumference defined by a circle passing through at least three locations of the at least three tissue anchor receivers on the implant member in the deployed configuration is smaller than a circumference defined by a circle passing through at least three locations of the embedded tissue anchors in the tissue prior to a physical coupling between the implant member and the embedded tissue anchors. 57. The implant kit of claim 37 wherein at least one of the tissue anchors comprises a helical tissue anchor. 58. The implant kit of claim 37 wherein the at least one of the tissue anchors comprises a grapple tissue anchor that includes at least two prongs pivotally coupled to each other, each of the two prongs having a tip shaped to pierce the tissue. 59. The implant kit of claim 37, further comprising a plurality of fasteners, each fastener movable along a respective one of the guide lines to a position where at least some of the fasteners secure the implant member to the tissue under tension in the deployed configuration. 60. The implant kit of claim 59 wherein each of the fasteners comprises a unidirectional clutch that in use allows the fastener to advance along a respective one of the guide lines toward a respective one of the embedded tissue anchors and prevents the fastener from retreating along the guide line away from the respective embedded tissue anchor. 61. The implant kit of claim 59 wherein the plurality of fasteners and the implant member are provided in a unitary structure. 62. The implant kit of claim 59 wherein the at least some of the fasteners are each fastenable to a respective one of the guide lines to secure the implant member to the tissue under tension in the deployed configuration. 63. The implant kit of claim 59 wherein the at least some of the fasteners are each directly fastenable to a respective one of the embedded tissue anchors to secure the implant member to the tissue under tension in the deployed configuration. 64. The implant kit of claim 37 wherein the implant member includes a plurality of guideline receivers, each of the guideline receivers having at least one of the guidelines passing therethrough, where all of the guidelines passing through a respective one of the receivers extend to a single respective one of the tissue anchors embedded in the tissue.
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