[미국특허]
Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-039/085
A61K-039/40
C07K-016/12
A61K-039/39
A61K-039/00
출원번호
US-0335411
(2014-07-18)
등록번호
US-9212219
(2015-12-15)
발명자
/ 주소
Schneewind, Olaf
Cheng, Alice
Missiakas, Dominique M.
Kim, Hwan Keun
출원인 / 주소
The University of Chicago
대리인 / 주소
Norton Rose Fulbright US LLP
인용정보
피인용 횟수 :
2인용 특허 :
86
초록▼
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant or an antibody directed thereto.
대표청구항▼
1. A method for enhancing a subject's ability to mount an immune response to a Staphylococcus aureus antigen comprising providing to the subject a composition comprising an isolated antibody that specifically binds to the nontoxigenic Staphylococcus aureus Protein A (SpA) variant polypeptide SpAKKAA
1. A method for enhancing a subject's ability to mount an immune response to a Staphylococcus aureus antigen comprising providing to the subject a composition comprising an isolated antibody that specifically binds to the nontoxigenic Staphylococcus aureus Protein A (SpA) variant polypeptide SpAKKAA, wherein the antibody enhances the subject's ability to mount an immune response to a Staphylococcus aureus antigen selected from the group consisting of FnBpA, FnBpB, LukD, LukE, LukF, SasA, SasD, SasG, SasI, SasK, Ebh, Emp, EsaB, EsaC, EsxA, EsxB, SdrC, SdrD, SdrE, ClfA, ClfB, Coa, Hla, IsdC, SasF, vWbp, and vWh. 2. The method of claim 1, wherein the Staphylococcus aureus antigen is present in or on a Staphylococcus aureus bacterium. 3. The method of claim 1, further comprising providing to the subject the Staphylococcus aureus antigen. 4. The method of claim 3, wherein the Staphylococcus aureus antigen is present in or on a Staphylococcus aureus bacterium. 5. The method of claim 3, wherein the Staphylococcus aureus antigen is selected from the group consisting of FnBpA, FnBpB, LukD, LukE, LukF, SasA, SasD, SasG, SasI, SasK, Eap, Ebh, Emp, EsaB, EsaC, EsxA, EsxB, SdrC, SdrD, SdrE, IsdA, IsdB, ClfA, ClfB, Coa, Hla, IsdC, SasF, vWbp, and vWh. 6. The method of claim 1, wherein the antibody is a polyclonal antibody, a monoclonal antibody, or an antibody fragment. 7. The method of claim 1, wherein the antibody was generated using the SpA polypeptide SPAKKAA as an antigen. 8. The method of claim 1, wherein the subject is at risk of developing a Staphylococcus aureus infection. 9. The method of claim 1, wherein the subject has a Staphylococcus aureus infection.
Schneewind, Olaf; Cheng, Alice; Missiakas, Dominique M.; Kim, Hwan Keun, Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response.
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Schneewind, Olaf; Cheng, Alice; Missiakas, Dominique M.; Kim, Hwan Keun, Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response.
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