Chewing gum in the form of multi-layer tablets
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A23G-004/00
A23G-004/18
A23L-001/236
A61K-009/20
A23G-003/34
A23G-004/04
A23G-004/12
A23G-004/20
A61K-009/68
출원번호
US-0545348
(2004-01-20)
등록번호
US-9216157
(2015-12-22)
우선권정보
EP-03003813 (2003-02-20)
국제출원번호
PCT/EP2004/000371
(2004-01-20)
§371/§102 date
20060331
(20060331)
국제공개번호
WO2004/073691
(2004-09-02)
발명자
/ 주소
Salini, Alberto
출원인 / 주소
Jagotec AG
대리인 / 주소
Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
인용정보
피인용 횟수 :
0인용 특허 :
10
초록▼
Disclosed are tablets having a sandwich-like structure comprising at least one inner layer of gum base containing one or more active pharmaceutical, dietetic or nutritional ingredients and two non-contigous outer layers comprising antiadhesion excipients and compression adjuvants preventing the adhe
Disclosed are tablets having a sandwich-like structure comprising at least one inner layer of gum base containing one or more active pharmaceutical, dietetic or nutritional ingredients and two non-contigous outer layers comprising antiadhesion excipients and compression adjuvants preventing the adhesion to the punches of the tabletting machine and possibly active ingredients which are the same as or different from those present in the inner layer. Said tablets are obtainable by direct compression of mixtures or granulates of the various components of each layer.
대표청구항▼
1. Chewing gum tablets containing one or more active pharmaceutical, dietetic or nutritional ingredients, said tablets comprising at least one inner core layer of gum base and a plurality of outer layers not in contact one with the other and respectively coating only the upper and bottom part of the
1. Chewing gum tablets containing one or more active pharmaceutical, dietetic or nutritional ingredients, said tablets comprising at least one inner core layer of gum base and a plurality of outer layers not in contact one with the other and respectively coating only the upper and bottom part of the gum core, leaving the peripheral side of the core uncoated, said outer layers consisting of compressed mixtures of powders, wherein said at least one inner layer of gum base comprises a gum component that is between 20 and 98% of the base; and said outer layers comprise antiadhesion excipients and compression adjuvants selected from isomalt, maltol, maltodextrin, maltitol, mannitol, xylitol, lactitol, lactose, skim milk, eritritol, oligofructose, retrograded starch, polysorbates, polyethyleneoxide, dextrans, cyclodextrins, oligosaccharose, fructose, and hydrogenated starch hydrosilates. 2. Tablets as claimed in claim 1, comprising two, three or more inner layers of gum base, wherein each inner layer contains active ingredients which are the same as or different from those present in the other layers. 3. Tablets as claimed in claim 1, wherein the one or more active ingredients is present in one or more of the plurality of outer layers. 4. Tablets as claimed in claim 1, obtainable by direct compression of the mixtures of powders or granulates of each layer. 5. Tablets as claimed in claim 2, wherein the active ingredients are selected from analgesic, antipyretic, anaesthetic, anti-allergic, anti-inflammatory, antifungal and bronchodilator drugs, antibiotics, drugs active on the cardiovascular system, decongestants, disinfectants, expectorants, mucolytics, cough suppressants, anorectics, spasmolytics, probiotics, probiotics, and enzymes. 6. Tablets as claimed in claim 1, wherein the layers of gum base contain a plasticizer selected from sorbitol, xylitol, maltitol, isomalt, maltol, mannitol, maltodextrins and cyclodextrins. 7. Tablets as claimed in claim 6, wherein said plasticizer is present in the percentage of between 0.5 and 70.0% by weight. 8. A process for the preparation of the tablets of claim 1, comprising subjecting to direct tabletting in a multi-hopper machine a gum base composition containing anti adhesion excipients,supplying first into a compression die a first portion of the antiadhesion excipients from a first hopper, followed by a gum base from a different hopper, and then a second portion of antiadhesion excipients from a third hopper and subjecting to compression the resulting layers. 9. Tablets obtainable by the process of claim 8. 10. Tablets as claimed in claim 1 wherein the active component content is between 2% and 60% on the weight of the layer in which said active component is carried. 11. Tablets as claimed in claim 2, wherein the active component content is between 2 and 60% on the weight of the layer in which said active component is carried.
Beringer Monique (2 ; RUE Alexandre Lauly F-68300 Saint Louis FRX) Woltmann Siegfried (Hauptstrasse 255 CH-4322 Mumpf CHX), Process for the manufacture of a multi-zone tablet and tablet manufactured by this process.
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