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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0047677 (2013-10-07) |
등록번호 | US-9220596 (2015-12-29) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 350 |
Compositions, materials, methods and kits for bone grafting are described. In some embodiments, a bone graft composition includes about 15% to about 20% by weight collagen, about 55% to about 70% by weight bioactive glass, and about 15% to about 30% by weight a calcium phosphate. The bioactive glass
Compositions, materials, methods and kits for bone grafting are described. In some embodiments, a bone graft composition includes about 15% to about 20% by weight collagen, about 55% to about 70% by weight bioactive glass, and about 15% to about 30% by weight a calcium phosphate. The bioactive glass and the calcium phosphate together are about 80% to about 85% by weight of the bone graft composition. In some embodiments, a bone graft composition includes a collagen matrix and a plurality of bioactive glass particulates dispersed throughout the collagen matrix. The collagen matrix is about 20% to about 60% by weight of the bone graft composition, and the bioactive glass is about 40% to about 80% of the bone graft composition. In some embodiments, a majority of the bioactive glass particulates are about 53 μm to about 425 μm in size.
1. A bone graft composition comprising: about 15% to about 20% by weight collagen;about 55% to about 70% by weight bioactive glass, the bioactive glass having a size within a range of about 53 μm to about 425 μm in size, at least 85% of the bioactive glass having a size within a range of 212 μm to 4
1. A bone graft composition comprising: about 15% to about 20% by weight collagen;about 55% to about 70% by weight bioactive glass, the bioactive glass having a size within a range of about 53 μm to about 425 μm in size, at least 85% of the bioactive glass having a size within a range of 212 μm to 425 μm in size; andabout 15% to about 30% by weight calcium phosphate. 2. The bone graft composition of claim 1, wherein the bioactive glass and the calcium phosphate together are about 80% to about 85% by weight of the bone graft composition. 3. The bone graft composition of claim 1, wherein the collagen is type I collagen. 4. The bone graft composition of claim 1, wherein the bioactive glass includes particles having a smooth surface. 5. The bone graft composition of claim 1, wherein the calcium phosphate comprises about 40% to about 80% tricalcium phosphate and about 20% to about 60% hydroxyapatite. 6. The bone graft composition of claim 5, further comprising about 15% by weight type I collagen, about 55% to about 65% by weight bioactive glass, and about 20% to about 30% by weight calcium phosphate. 7. The bone graft composition of claim 6, wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:55%:30%, respectively. 8. The bone graft composition of claim 6, wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:60%:25%, respectively. 9. The bone graft composition of claim 6, wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:65%:20%, respectively. 10. The bone graft composition of claim 1, wherein the bioactive glass is 45S5 glass. 11. A bone graft composition consisting of: a collagen and a bioactive glass dispersed throughout the collagen, the bioactive glass having a size within a range of about 53 μm to about 425 μm, at least 85% of the bioactive glass having a size within a range of 212 μm to 425 μm; the collagen and the bioactive glass collectively comprising 100% by weight of the bone graft composition, the collagen being about 20% to about 60% by weight of the bone graft composition and the bioactive glass is about 40% to about 80% by weight of the bone graft composition. 12. The bone graft composition of claim 11, wherein the collagen is in the form of a porous matrix. 13. The bone graft composition of claim 11, wherein the bioactive glass has a smooth surface. 14. The bone graft composition of claim 11, wherein the bioactive glass is about 80% by weight of the bone graft composition. 15. The bone graft composition of claim 11, wherein the bioactive glass is about 60% by weight of the bone graft composition. 16. The bone graft composition of claim 11, wherein the bioactive glass is 45S5 glass. 17. The bone graft composition of claim 11, wherein the collagen includes type I collagen.
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