[특허]Nogo receptor antagonists and methods of increasing neurite outgrowth

[미국특허] Nogo receptor antagonists and methods of increasing neurite outgrowth 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C07K-016/28 A01K-067/027 C07K-014/705 C12N-015/113 C12N-015/85 A61K-038/17 A61K-039/395 A61K-048/00 A61K-039/00
출원번호	US-0146345 (2014-01-02)
등록번호	US-9228015 (2016-01-05)
발명자 / 주소	Lee, Daniel H. S. Wen, Dingyi Pepinsky, R. Blake Relton, Jane K. Wang, Xinzhong Lugovskoy, Alexey Meier, Werner Garber, Ellen A. Silvian, Laura Weinreb, Paul H.
출원인 / 주소	Biogen Idec MA Inc.
대리인 / 주소	Choate, Hall & Stewart LLP
인용정보	피인용 횟수 : 0 인용 특허 : 24

초록 ▼

Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.

대표청구항 ▼

1. A method of treating a central nervous system (CNS) disease, disorder, or injury in a mammal selected from the group comprising stroke, spinal cord injury, optic neuritis, and glaucoma, comprising administering to a mammal in need of treatment an effective amount of an agent comprising a NogoR polypeptide variant comprising: a sNogoR310 polypeptide, comprising the amino acid sequence of residues 27-310 of SEQ ID NO: 58; andan antibody fragment, crystallizable (Fc):wherein the Fc is joined to the sNogoR310 c-terminus,wherein the NogoR variant inhibits neurite outgrowth inhibition. 2. The method of claim 1 wherein the subject receives a NogoR polypeptide variant in combination with another therapy. 3. The method of claim 1, wherein the agent comprises a dimeric peptide comprising two of the NogoR variants. 4. A method of enhancing neurite outgrowth comprising administering to a mammal in need of treatment an effective amount of an agent comprising a NogoR polypeptide variant comprising: a sNogoR310 polypeptide, comprising the amino acid sequence of residues 27-310 of SEQ ID NO: 58: andan antibody fragment, crystallizable (Fc);wherein the Fc is joined to the sNogoR310 c-terminus,wherein the NogoR variant inhibits neurite outgrowth inhibition. 5. The method of claim 1, wherein the CNS disease, disorder, or injury is a spinal cord injury.

이 특허에 인용된 특허 (24) 인용/피인용 타임라인 분석

Steven M. Ruben ; Jian Ni ; Craig A. Rosen ; Ying-Fei Wei ; Paul Young ; Kimberly Florence ; Daniel R. Soppet ; Laurie A. Brewer ; Gregory A. Endress ; Kenneth C. Carter ; Michael Mucenski , 94 Human Secreted Proteins.
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Ruben, Steven M.; Ni, Jian; Rosen, Craig A.; Wei, Ying-Fei; Young, Paul; Florence, Kimberly; Soppet, Daniel R.; Brewer, Laurie A.; Endress, Gregory A.; Carter, Kenneth C.; Mucenski, Michael; Ebner, R, Antibodies to secreted protein HCEJQ69.
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Ruben, Steven M.; Rosen, Craig A.; LaFleur, David W., Antibodies to secreted protein HCEJQ69.
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Adair John Robert,GBX ; Bodmer Mark William,GBX ; Mountain Andrew,GBX ; Owens Raymond John,GBX, CDR grafted anti-CEA antibodies and their production.
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Tom Henry K. (La Honda CA) Rowley Gerald L. (Cupertino CA), Concentrating zone method in heterogeneous immunoassays.
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Koszinowski Ulrich H. (Tbingen DEX) Keil Gnther M. (Tbingen DEX) Dorsch-Hsler Karoline (Zrich CHX) Schaffner Walter (Weiningen CHX), Deoxyribonucleic acid segment from a virus.
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Ladner Robert C. (Ijamsville MD) Guterman Sonia K. (Belmont MA) Roberts Bruce L. (Milford MA) Markland William (Milford MA) Ley Arthur C. (Newton MA) Kent Rachel B. (Boxborough MA), Directed evolution of novel binding proteins.
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Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA), Fluorescence quenching with immunological pairs in immunoassays.
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Kronick Melvyn N. (Palo Alto CA) Little William A. (Palo Alto CA), Fluorescent immunoassay employing total reflection for activation.
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Litman David J. (Palo Alto CA) Harel Zvi (Stanford CA) Ullman Edwin F. (Atherton CA), Macromolecular environment control in specific receptor assays.
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Lee, Daniel H. S.; Wen, Dingyi; Pepinsky, R. Blake; Relton, Jane K.; Wang, Xinzhong; Lugovskoy, Alexey; Meier, Werner; Garber, Ellen A.; Silvian, Laura; Weinreb, Paul H., Nogo receptor antagonists.
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Strittmatter,Stephen M.; Cate,Richard L.; Sah,Dinah W. Y., Nogo receptor homologs.
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Strittmatter,Stephen M., Nogo receptor-mediated blockade of axonal growth.
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Kingsbury,Gillian, Nucleic acid encoding human tango 509.
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Axel Richard (New York NY) Wigler Michael H. (Cold Spring Harbor NY) Silverstein Saul J. (Irvington NY), Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials.
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Axel Richard (New York NY) Wigler Michael H. (Cold Spring Harbor NY) Silverstein Saul J. (Irvington NY), Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials.
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Cabilly Shmuel (Monrovia CA) Heyneker Herbert L. (Burlingame CA) Holmes William E. (Pacifica CA) Riggs Arthur D. (La Verne CA) Wetzel Ronald B. (San Francisco CA), Recombinant immunoglobin preparations.
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A	생활필수품
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[미국특허] Nogo receptor antagonists and methods of increasing neurite outgrowth 원문보기