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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0281640 (2014-05-19) |
등록번호 | US-9234863 (2016-01-12) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 454 |
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agen
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
1. A method for determining a concentration of an analyte in a sample, comprising: contacting a sample fluid with a sensor positioned in an analyte meter, wherein the sensor comprises: a first electrode, a second electrode, and a third electrode;a sample chamber for holding the sample fluid, the sam
1. A method for determining a concentration of an analyte in a sample, comprising: contacting a sample fluid with a sensor positioned in an analyte meter, wherein the sensor comprises: a first electrode, a second electrode, and a third electrode;a sample chamber for holding the sample fluid, the sample chamber comprising the first electrode, the second electrode, and the third electrode; andan analyte-responsive enzyme and a redox mediator disposed in the sample chamber;applying a first potential between the first and second electrodes using the analyte meter and detecting a change in an electrical signal between the first and second electrodes to determine when the sample fluid contacts the first and second electrodes;applying a second potential between the first and third electrodes using the analyte meter and determining whether a change in an electrical signal occurs between the first and third electrodes to determine whether the sample fluid contacts the first and third electrodes; andsubsequent to applying the potential between the first and third electrodes, determining an analyte concentration only upon detecting a change in an electrical signal between the first and second electrodes and a change in an electrical signal between the first and third electrodes. 2. The method according to claim 1, wherein detecting a change in an electrical signal between the first and second electrodes comprises detecting a voltage, current, resistance, impedance, capacitance, or combination thereof between the first and second electrodes. 3. The method according to claim 2, wherein detecting a change in an electrical signal between the first and second electrodes comprises detecting the production of a current between the first and second electrodes. 4. The method according to claim 1, wherein determining whether a change in an electrical signal occurs between the first and third electrodes comprises determining whether a voltage, current, resistance, impedance, capacitance, or combination thereof occurs between the first and third electrodes. 5. The method according to claim 4, wherein determining whether a change in an electrical signal occurs between the first and third electrodes comprises determining whether a current is produced between the first and third electrodes. 6. The method according to claim 1, wherein the first, second, and third electrodes are coplanar. 7. The method according to claim 1, wherein the sensor is a tip-fill sensor. 8. The method according to claim 1, wherein the sensor is a side-fill sensor. 9. The method according to claim 1, wherein the sample chamber is sized to contain a volume of no more than 1 μL of the sample fluid. 10. The method according to claim 9, wherein the sample chamber is sized to contain a volume of no more than 0.5 μL of the sample fluid. 11. The method according to claim 1, wherein the analyte is glucose. 12. The method according to claim 11, wherein the analyte-responsive enzyme is glucose oxidase or glucose dehydrogenase. 13. The method according to claim 1, wherein the analyte is a ketone. 14. The method according to claim 1, wherein the sample fluid is a blood sample, and wherein the method further comprises obtaining the blood sample from a finger of a subject. 15. The method according to claim 1, wherein the sample fluid is a blood sample, and wherein the method further comprises obtaining the blood sample from a region of a subject having a lower nerve end density as compared to a fingertip. 16. The method according to claim 15, wherein the region of a subject having a lower nerve end density as compared to a fingertip is selected from the group consisting of: a forearm region, and a thigh region.
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