Personalized auditory-somatosensory stimulation to treat tinnitus
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-021/02
H04R-025/00
A61M-021/00
출원번호
US-0217090
(2014-03-17)
등록번호
US-9242067
(2016-01-26)
발명자
/ 주소
Shore, Susan
Martel, David
Koehler, Seth
출원인 / 주소
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
대리인 / 주소
Marshall, Gerstein & Borun LLP
인용정보
피인용 횟수 :
1인용 특허 :
9
초록
Timed stimulation of both somatosensory system and auditory system is controlled, in such a manner, that an individual's brain activity is altered through spike-timing dependent plasticity, thereby reducing or removing tinnitus.
대표청구항▼
1. A computer-implementable method of treating tinnitus in a subject, the method comprising: generating, in an audible signal generator, an audible stimulation signal having a first firing point and first firing period, stimulus onset, and/or duration;generating, in an electrical signal generator, a
1. A computer-implementable method of treating tinnitus in a subject, the method comprising: generating, in an audible signal generator, an audible stimulation signal having a first firing point and first firing period, stimulus onset, and/or duration;generating, in an electrical signal generator, a somatosensory stimulation signal to stimulate a somatosensory system of a subject, the somatosensory stimulation signal having a second firing point and second firing period, stimulus onset, and/or duration; andestablishing, in a processor coupled to the audible signal generator and the electrical signal generator, a timing order and timing difference between the first firing point and the second firing point to reduce the tinnitus, wherein the first firing period and the second firing period are to be maintained asynchronously to reduce the tinnitus so that the firing period does not overlap the second firing period; andapplying the somatosensory stimulation signal to the somatosensory system of the subject, and applying the audible stimulation signal to an auditory system of the subject. 2. The method of claim 1, further comprising changing the timing order between the first firing point and the second firing point to determine a desired reduction in the tinnitus. 3. The method of claim 1, further comprising adjusting the timing difference between the first firing point and the second firing point to determine a desired reduction in the tinnitus. 4. The method of claim 1, further comprising applying the somatosensory stimulation signal to the subject by applying stimulation to a brain of the subject to stimulate the somatosensory system. 5. The method of claim 4, further comprising applying the somatosensory stimulation signal to the subject by applying stimulation to a trigeminal nerve of the subject via facial stimulation or a cervical spinal nerve of the subject to stimulate the somatosensory system. 6. The method of claim 4, further comprising applying the somatosensory stimulation signal to the subject by applying stimulation to a deep brain region of the subject to stimulate the somatosensory system. 7. The method of claim 4, further comprising applying the somatosensory stimulation signal to the subject by applying stimulation to a surface region of a brain of the subject or to a surface structure on a face or a surface structure on a neck of the subject to stimulate the somatosensory system. 8. The method of claim 1, wherein at least one of the auditory stimulation signal and the somatosensory stimulation signal is provided to the subject through mechanical or electrical stimulation. 9. The method of claim 1, further comprising: determining a timing profile for the subject, the timing profile containing timing data of different timing orders and timing differences between the first firing point and the second firing point and containing perceived tinnitus data for the different timing orders and timing differences; andstoring the timing profile for access in determining a suggested tinnitus treatment regimen for the auditory stimulation signal and the somatosensory stimulation signal. 10. The method of claim 1, further comprising: determining an initial timing profile for the subject, the timing profile containing an initial timing order and timing difference for the first firing point and the second firing point, and determined to reduce the tinnitus after onset. 11. The method of claim 1, further comprising: receiving an indication of the onset of the tinnitus; andautomatically establishing the timing order and the timing difference between the first firing point and the second firing point to reduce the tinnitus. 12. The method of claim 1, further comprising: adjusting, over a period of time, the timing order and the timing difference between the first firing point and the second firing point to determine a tinnitus reduction profile for the period of time; andstoring the tinnitus reduction profile. 13. The method of claim 12, wherein establishing the timing order and the timing difference between the first firing point and the second firing point comprises: accessing the tinnitus reduction profile; anddetermining the timing order and the timing difference from the tinnitus reduction profile. 14. The method of claim 12, wherein establishing the timing order and the timing difference between the first firing point and the second firing point comprises: identifying a treatment time;accessing the tinnitus reduction profile;identifying the timing order and the timing difference corresponding to the treatment time from the tinnitus reduction profile; andapplying the generated auditory stimulation signal and somatosensory stimulation signal based on the identified corresponding timing order and timing difference. 15. The method of claim 12, wherein the identified treatment time is a present time. 16. The method of claim 12, wherein the identified treatment time is a future time. 17. The method of claim 1, further comprising: adjusting the first firing period and/or the second firing period to reduce the tinnitus. 18. The method of claim 1, further comprising: periodically adjusting the first firing period and/or the second firing period to reduce the tinnitus. 19. The method of claim 1, further comprising: adjusting the timing order and the timing difference between the first firing point and the second firing point to selectively increase or decrease firing rates in an identified neurons. 20. A system for treating an auditory condition in a subject, the system being capable of stimulating (i) a somatosensory system of the subject with a generated somatosensory stimulation signal and (ii) an auditory system of the subject with an audible stimulation signal, the system comprising: a bimodal stimulation system having an audible signal generator, a somatosensory signal generator, a processor, and a memory, wherein the processor is operatively coupled to the audible signal generator and the somatosensory signal generator to control each, and wherein the bimodal stimulation system is configured to,generate, in the audible signal generator, the audible stimulation signal having a first firing point and first firing period, stimulus onset, and/or duration, andgenerate, in the somatosensory signal generator, the somatosensory stimulation signal to stimulate a somatosensory system of a subject, the somatosensory stimulation signal having a second firing point and second firing period, stimulus onset, and/or duration,wherein the memory stores instructions that when executed by the processor cause the processor to:establish a timing order and timing difference between the first firing point and the second firing point to reduce the auditory condition, wherein the first firing period and the second firing period are to be maintained asynchronously to reduce the auditory condition so that the onset of the first firing period does not overlap the onset of the second firing period. 21. The system of claim 20, wherein the bimodal stimulation system is further configured to change the timing order between the first firing point and the second firing point to determine a desired reduction in the auditory condition. 22. The system of claim 20, wherein the bimodal stimulation system is further configured to adjust the timing difference between the first firing point and the second firing point to determine a desired reduction in the auditory condition. 23. The system of claim 20, wherein the bimodal stimulation system is further configured to apply the somatosensory stimulation signal to the subject by applying stimulation to a brain of the subject through one or more electrodes to stimulate the somatosensory system. 24. The system of claim 23, wherein the bimodal stimulation system is further configured to apply the somatosensory stimulation signal to the subject by applying stimulation to a trigeminal nerve of the subject via facial stimulation through one or more electrodes or a cervical spinal nerve of the subject through one or more electrodes to stimulate the somatosensory system. 25. The system of claim 23, wherein the bimodal stimulation system is further configured to apply the somatosensory stimulation signal to the subject by applying stimulation to a deep brain region of the subject through one or more electrodes to stimulate the somatosensory system. 26. The system of claim 23, wherein the bimodal stimulation system is further configured to apply the somatosensory stimulation signal to the subject by applying stimulation to a surface region of a brain of the subject through one or more electrodes or to a surface structure on a face or a surface structure on a neck of the subject through one or more electrodes to stimulate the somatosensory system. 27. The system of claim 20, wherein at least one of the auditory stimulation signal and the somatosensory stimulation signal is provided to the subject through a mechanical or electrical stimulation. 28. The system of claim 20, wherein the bimodal stimulation system is further configured to: determine a timing profile for the subject, the timing profile containing timing data of different timing orders and timing differences between the first firing point and the second firing point and containing perceived auditory condition data for the different timing orders and timing differences; andstore the timing profile for access in determining a suggested auditory condition treatment regimen for the auditory stimulation signal and the somatosensory stimulation signal. 29. The system of claim 20, wherein the bimodal stimulation system is further configured to: determine an initial timing profile for the subject, the timing profile containing an initial timing order and timing difference for the first firing point and the second firing point, and determined to reduce the auditory condition after onset. 30. The system of claim 20, wherein the bimodal stimulation system is further configured to: receive an indication of the onset of the auditory condition; andautomatically establish the timing order and the timing difference between the first firing point and the second firing point to reduce the auditory condition. 31. The system of claim 20, wherein the bimodal stimulation system is further configured to: adjust, over a period of time, the timing order and the timing difference between the first firing point and the second firing point to determine an auditory condition reduction profile for the period of time; andstore the auditory condition reduction profile. 32. The system of claim 20, wherein the bimodal stimulation system is further configured to establish the timing order and the timing difference between the first firing point and the second firing point by: accessing an auditory condition reduction profile; anddetermining the timing order and the timing difference from the auditory condition reduction profile. 33. The system of claim 20, wherein the bimodal stimulation system is further configured to establish the timing order and the timing difference between the first firing point and the second firing point by: identifying a treatment time;accessing an auditory condition reduction profile;identifying the timing order and the timing difference corresponding to the treatment time from the auditory condition reduction profile; andapplying the generated auditory stimulation signal and somatosensory stimulation signal based on the identified corresponding timing order and timing difference. 34. The system of claim 33, wherein the identified treatment time is a present time. 35. The system of claim 33, wherein the identified treatment time is a future time. 36. The system of claim 20, wherein the bimodal stimulation system is further configured to adjust the first firing period and/or the second firing period to reduce the auditory condition. 37. The system of claim 20, wherein the bimodal stimulation system is further configured to periodically adjust the first firing period and/or the second firing period to reduce the auditory condition. 38. The system of claim 20, wherein the bimodal stimulation system is further configured to adjust the timing order and the timing difference between the first firing point and the second firing point to selectively increase or decrease firing rates in an identified neurons. 39. The system of claim 20, wherein the auditory condition is tinnitus. 40. The system of claim 20, wherein the auditory condition is hyperacusis. 41. A non-transitory computer-readable storage medium having stored thereon a set of instructions, executable by a processor, for treating an auditory condition in a subject, the instructions comprising: instructions for generating an audible stimulation signal having a first firing point and first firing period, stimulus onset, and/or duration;instructions for generating a somatosensory stimulation signal to stimulate a somatosensory system of a subject, the somatosensory stimulation signal having a second firing point and second firing period, stimulus onset, and/or duration; andinstructions for establishing a timing order and timing difference between the first firing point and the second firing point to reduce auditory condition, wherein the first firing period and the second firing period are to be maintained asynchronously to reduce the auditory condition so that the first firing period does not overlap the second firing period; andinstructions for controlling a somatosensory signal generator to apply the somatosensory stimulation signal to the somatosensory system of the subject, and instructions for controlling an audible signal generator to apply the audible stimulation signal to an auditory system of the subject for reducing tinnitus in the subject. 42. The non-transitory computer-readable storage medium of claim 41, wherein the auditory condition is the tinnitus. 43. The non-transitory computer-readable storage medium of claim 41, wherein the auditory condition is hyperacusis. 44. The non-transitory computer-readable storage medium of claim 41, the instructions further comprising: instructions for determining optimal parameter values for an audible stimulation signal and a somatosensory stimulation signal to alter firing rates for neurons in the auditory and non-auditory pathways involved in the auditory condition. 45. The non-transitory computer-readable storage medium of claim 41, the instructions further comprising: instructions for increasing firing rates for the neurons in the auditory and non-auditory pathways involved in the auditory condition. 46. The non-transitory computer-readable storage medium of claim 41, the instructions further comprising: instructions for decreasing firing rates for the neurons in the auditory and non-auditory pathways involved in the auditory condition.
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이 특허에 인용된 특허 (9)
De Ridder, Dirk, Peripheral nerve stimulation to treat auditory dysfunction.
Davis, Paul Benjamin; James, Lachlan Stewart; McSweeney, Benjamin Adam; Laidlaw, Linda Elizabeth; Frater, Robert Henry; Hanley, Peter John, Tinnitus rehabiliation device and method.
Davis, Paul B.; James, Lachlan S.; McSweeney, Benjamin A.; Laidlaw, Linda E.; Frater, Robert H.; Hanley, Peter J., Tinnitus rehabilitation device and method.
Davis, Paul Benjamin; James, Lachlan Stewart; McSweeney, Benjamin Adam; Laidlaw, Linda Elizabeth; Frater, Robert Henry; Hanley, Peter John, Tinnitus rehabilitation device and method.
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