Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
대표청구항▼
1. A lung care module comprising: a single use disposable module including an interface adapted for attachment to a multiple use module, and a lung chamber assembly having a first interface for allowing a flow of a perfusion fluid into the lung and a second interface for allowing ventilation of the
1. A lung care module comprising: a single use disposable module including an interface adapted for attachment to a multiple use module, and a lung chamber assembly having a first interface for allowing a flow of a perfusion fluid into the lung and a second interface for allowing ventilation of the lung with a ventilation gas; anda drain system for draining a flow of perfusion fluid from the lung chamber assembly, the drain system including a measurement conduit and a main drain conduit, the measurement conduit further directing a flow of perfusion fluid to a sensor that is adapted to measure a perfusion fluid gas content. 2. The system of claim 1 further comprising a ventilation system connected to the second interface for ventilating the lung with a gas. 3. The system of claim 2, wherein the gas is selectable from a plurality of gases, each of the plurality of gases having a predetermined composition. 4. The system of claim 3, wherein the plurality of gases includes a maintenance gas, an assessment gas, and air. 5. The system of claim 4, wherein the predetermined composition of the maintenance gas includes about 12% oxygen. 6. The system of claim 4, wherein the predetermined composition of the maintenance gas is about 12% oxygen, about 5.5% carbon dioxide, and about 82.5% nitrogen. 7. The system of claim 4, wherein the predetermined composition of the assessment gas includes about 6% carbon dioxide. 8. The system of claim 4, wherein the predetermined composition of the assessment gas includes about 4-7% carbon dioxide and about 93-97% nitrogen. 9. The system of claim 2, wherein the ventilation system can be configured to cause the lung to rebreath a volume of the maintenance gas. 10. The system of claim 9, wherein the ventilation system includes an isolated volume compartment, and the volume of maintenance gas is cycled between the lung and the isolated volume compartment. 11. The system of claim 9, wherein the ventilation system includes a bellows, and the volume of maintenance gas is cycled between the lung and the bellows by actuating the bellows. 12. The system of claim 9 wherein the ventilation system includes a connection to an external supply of maintenance gas via a trickle valve, the trickle valve releasing the gas into the ventilation system to maintain the predetermined composition of the maintenance gas in the ventilation system. 13. The system of claim 2, wherein the ventilation system further comprises a relief valve, the relief valve maintaining a minimum gas pressure in the lung. 14. The system of claim 1, wherein the second interface includes a tracheal cannula. 15. The system of claim 14, wherein the tracheal cannula comprises a tracheal insertion portion for inserting into the trachea, a flexible portion, a locking mechanism for securing the tracheal cannula to the lung chamber assembly, and a ventilator connector portion. 16. The system of claim 15, wherein the tracheal insertion portion has a diameter of about 0.65 inches to 0.95 inches. 17. The system of claim 15, wherein the flexible portion can be clamped to seal off gas flow in and out of the lung. 18. The system of claim 1 further comprising a pump adapted to flow the perfusion fluid into and away from the lung. 19. The system of claim 18 further comprising a heater in thermal contact with the perfusion fluid for maintaining a temperature of the perfusion fluid at a near physiologic level. 20. The system of claim 19, wherein the temperature is between about 30° C. and 37° C. 21. The system of claim 19, wherein the temperature is between about 34° C. and 37° C. 22. The system of claim 18 further comprising a gas exchange device in fluid communication with at least one gas supply and the perfusion fluid, the gas exchange device being adapted to controllably modulate the composition of a first gas component in the perfusion fluid. 23. The system of claim 22 further comprising a gas select switch for selecting from a plurality of gas supplies to modulate the composition of a gas component in the perfusion fluid. 24. The system of claim 18, wherein the first interface includes a pulmonary artery cannula. 25. The system of claim 24, wherein the pulmonary artery cannula includes an insertion tube for insertion into a pulmonary artery, a connector portion connected to the insertion tube, and a main tube portion connected to the connector portion for connection to a circuit carrying the flow of perfusion fluid into the lung. 26. The system of claim 25, wherein the pulmonary artery cannula further includes a pressure transducer connector, the pressure transducer connector defining an opening into a lumen of the connector portion near the insertion tube for positioning a pressure transducer near a point of entry of the perfusion fluid into the lung. 27. The system of claim 26, wherein the pressure transducer connector further provides a channel for the pressure transducer to be remotely vented. 28. The system of claim 26 wherein the pulmonary artery cannula includes two insertion tubes. 29. The system of claim 26, wherein the insertion tubes are angled apart from a main axis of the pulmonary artery cannula by an angle of between about 15 degrees and 90 degrees. 30. The system of claim 1, wherein a left atrial cuff of the lung is exposed to the lung chamber assembly for allowing the perfusion fluid to flow from the lung to the drain system. 31. The system of claim 1, wherein the disposable module further includes a includes a connection between a left atrial cuff and a cannula that directs the perfusion fluid from the lung to the drain system. 32. The system of claim 1, wherein the lung chamber assembly includes a housing, a support surface, and an openable lid. 33. The system of claim 32, wherein the support surface defines a drain and drainage channels for draining a perfusion fluid flowing out of the lung. 34. The system of claim 32, wherein the support surface is configured to secure a flexible wrap for providing support to and anchoring the lung. 35. The system of claim 34, wherein the flexible wrap comprises polyurethane.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (120)
Pedicini Christopher S. ; Witzigreuter John D., Air-managing system for metal-air battery using resealable septum.
Del Nido Pedro J. (Pittsburgh PA) Cao-Danh Hung (Pittsburgh PA) Sommers K. Eric (Pittsburgh PA) Ohkado Akihiko (Pittsburgh PA), An aqueous heart preservation and cardioplegia solution.
Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis; Fraser, Richard; Harris, Stanley; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
Martindale James G. (Costa Mesa CA) Purdy Ralph E. (Irvine CA) Stupecky George L. (Irvine CA) Tidwell Ronny G. (Irvine CA), Apparatus and method of preserving the viability of animal organs.
Heiberger Robert A. (Boulder CO) Ingebrigtsen Jon S. (Lakewood CO) Price James R. (Westminster CO), Apparatus for measurement of blood saturation and hematocrit.
Strasberg Steven M. (Toronto CAX) Harvey Robert P. C. (Oakville CAX), Composition for the preservation of organs comprising glucuronic acid or a physiologically tolerated salt or ester there.
Bacchi Bernard (Garches FRX) Marchot Patrick (Colombes FRX) Mauriat Philippe (Vanves FRX) Touati Gilles (Tours FRX) Pouard Philippe (Clamart FRX) Magnard Alain (Longpont sur Orge FRX) Thomas Philippe, Controlled-environment medical container.
Bakke Allan P. (609 19th Ave. SW. Rochester MN 55902), Electric blood warmer utilizing metallic ribbon flow cartridge and low thermal mass heating units.
Aboul-Hosn, Walid N.; Kanz, William R.; Cartwright, James W.; Shulock, Damien; McCrystle, Kelly J., Integrated pump and cannula system and related methods.
Vodovotz, Yoram; Gage, Frederick A., Kidney perfusion solution containing nitric oxide donor, inhibitor of NOS2, glutathione, gluconate and methods of use.
Bauer Dan O. (277 Kenwood Rd. Grosse Pointe Farms MI 48236) Bauer Neal W. (275 Merriweather Grosse Pointe Farms MI 48236), Kidney preservation machine.
Lindstrom Richard L. (1065 W. Ferndale Rd. Wayzata MN 55391) Skelnik Debra (P.O. Box 1758 ; Rte. 3 Cambridge MN 55008), Method and apparatus of a defined serumfree medical solution.
Hassanein, Waleed; Khayal, Tamer; Elbetanony, Ahmed; Lezberg, Paul; Cecere, Giovanni; Sousa, Dennis; Hansen, Elizabeth, Method for ex-vivo organ care and for using lactate as an indication of donor organ status.
Brasile Lauren (61 Meadow La. Albany NY 12208), Method for treating and rendering grafts nonthrombogenic and substantially nonimmunogenic using an extracellular matrix.
Hamilton Robin E. ; Kennedy Paul G. ; Ostop John ; Baker Martin L. ; Arlow Gregory A. ; Golombeck John C. ; Fagan ; Jr. Thomas J., Method of extracting heat from a semiconductor body and forming microchannels therein.
Haryadi Dinesh G.,INX ; Orr Joseph A. ; Kuck Kai,DEX ; Jaffe Michael B., Methods of non-invasively estimating intrapulmonary shunt fraction and measuring cardiac output.
David A. Bull ; Bruce C. Reid ; James C. Stringham ; Shreekanth V. Karwande, Organ preservative solution containing trehalose, anti-oxidant, cations and an energy source.
Segall Paul E. (Berkeley CA) Waitz Harold D. (Berkeley CA) Sternberg Hal (Berkeley CA) Segall Judith M. (Berkeley CA), Plasma expander and blood substitute.
Gardetto William W. ; Heacox John K. ; Matthews James L., Portable perfusion/oxygenation module having mechanically linked dual pumps and mechanically actuated flow control for.
Stern David M. (Great Neck NY) Oz Mehmet C. (Fort Lee NJ) Nowygrod Roman (Teaneck NJ) Koga Shin (New York NY) Pinsky David J. (Riverdale NY), Solution for prolonged organ preservation.
Stern David M. (Great Neck NY) Oz Mehmet C. (Fort Lee NJ) Nowygrod Roman (Teaneck NJ) Koga Shin (New York NY) Pinsky David J. (Riverdale NY), Solution for prolonged organ preservation.
Hassanein, Waleed; Khayal, Tamer; Havener, Robert; Kyi, Stanley; Fattah, Ihab Abdel; Saleh, Hesham; Trachtenberg, Jon, Systems and methods for ex vivo organ care.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.