[특허]Long-acting coagulation factors and methods of producing same

[미국특허] Long-acting coagulation factors and methods of producing same 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-038/36 C07K-014/745 C12N-009/96 C07K-014/505 C07K-014/59 C12N-009/64 A61K-038/00 A61K-038/48
출원번호	US-0932839 (2013-07-01)
등록번호	US-9249407 (2016-02-02)
발명자 / 주소	Fima, Udi Eyal Hart, Gili
출원인 / 주소	OPKO BIOLOGICS LTD.
대리인 / 주소	Cohen, Mark S.
인용정보	피인용 횟수 : 0 인용 특허 : 77

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Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polyn

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1. A method of reducing excessive bleeding in a subject, the method comprising the step of administering a pharmaceutical composition comprising a CTP-modified activated Factor VII (FVIIa) polypeptide to the subject, wherein said CTP-modified activated Factor VII (FVIIa) polypeptide comprises a FVII polypeptide and three to five chorionic gonadotropin carboxy terminal peptides (CTPs) attached to the carboxy terminus of said CTP-modified FVII polypeptide, thereby reducing excessive bleeding in said subject. 2. The method of claim 1, wherein the sequence of said modified Factor VII (FVII) polypeptide CTP-modified activated Factor VII (FVIIa) polypeptide is selected from the group consisting of SEQ ID NO: 25, 27, 29, and 46. 3. The method of claim 1, wherein the sequence of at least one CTP is SEQ ID NO: 1 or SEQ ID NO: 2. 4. The method of claim 1, wherein at least one CTP is glycosylated. 5. The method of claim 1, wherein at least one CTP is truncated. 6. The method of claim 1, wherein at least one CTP is attached to said activated Factor VII (FVIIa) polypeptide via a linker. 7. The method of claim 6, wherein said linker is a peptide bond. 8. The method of claim 1, wherein the subject is a human child. 9. The method of claim 1, wherein said administering is via the subcutaneous route. 10. The method of claim 1, wherein said administering is via the intravenous route. 11. The method of claim 1, wherein said subject is afflicted with hemophilia. 12. The method of claim 1, wherein said subject is afflicted with vitamin K deficiency. 13. The method of claim 1, wherein said polypeptide further comprises a signal peptide. 14. The method of claim 13, wherein said signal peptide is set forth in SEQ ID NO: 47. 15. A method of reducing excessive bleeding in a subject, the method comprising the step of administering to the subject a pharmaceutical composition comprising a CTP-modified Factor IX (FIX) polypeptide, wherein said CTP-modified Factor IX (FIX) polypeptide comprises a FIX polypeptide and three to five chorionic gonadotropin carboxy terminal peptides (CTPs) attached to the carboxy terminus of said CTP-modified Factor IX (FIX) polypeptide, thereby reducing excessive bleeding in said subject. 16. The method of claim 15, wherein the sequence of said CTP-modified coagulation factor polypeptide is SEQ ID NO: 31. 17. The method of claim 15, wherein the sequence of at least one CTP is ID NO: 1 or SEQ ID NO: 2. 18. The method of claim 15, wherein at least one CTP is glycosylated. 19. The method of claim 15, wherein at least one CTP is truncated. 20. The method of claim 15, wherein at least one CTP is attached to said Factor IX (FIX) polypeptide via a linker. 21. The method of claim 15, wherein said linker is a peptide bond. 22. The method of claim 15, wherein the subject is a human child. 23. The method of claim 15, wherein said administering is via the subcutaneous route. 24. The method of claim 15, wherein said administering is via the intravenous route. 25. The method of claim 15, wherein said subject is afflicted with hemophilia B.

이 특허에 인용된 특허 (77) 인용/피인용 타임라인 분석

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[미국특허] Long-acting coagulation factors and methods of producing same 원문보기

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