[미국특허]
Implantable materials having engineered surfaces and method of making same
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61L-031/16
A61F-002/00
A61F-002/02
출원번호
US-0219924
(2014-03-19)
등록번호
US-9272077
(2016-03-01)
발명자
/ 주소
Palmaz, Julio C.
출원인 / 주소
Palmaz Scientific, Inc.
대리인 / 주소
Rosenbaum, David G.
인용정보
피인용 횟수 :
0인용 특허 :
58
초록▼
An implantable biocompatible material includes one or more vacuum deposited layers of biocompatible materials deposited upon a biocompatible base material. At least a top most vacuum deposited layer includes a homogeneous molecular pattern of distribution along the surface thereof and comprises a pa
An implantable biocompatible material includes one or more vacuum deposited layers of biocompatible materials deposited upon a biocompatible base material. At least a top most vacuum deposited layer includes a homogeneous molecular pattern of distribution along the surface thereof and comprises a patterned array of geometric physiologically functional features.
대표청구항▼
1. A method for making an implantable, biocompatible material, comprising the steps of: a. providing an implantable, biocompatible material having at least one surface intended to contact tissue and body fluids in vivo;b. providing a mask having a defined pattern of openings corresponding in size an
1. A method for making an implantable, biocompatible material, comprising the steps of: a. providing an implantable, biocompatible material having at least one surface intended to contact tissue and body fluids in vivo;b. providing a mask having a defined pattern of openings corresponding in size and spacing to a predetermined distribution of endothelial cell binding domains to be imparted to the at least one surface;c. treating the at least one surface of the biocompatible material through the mask by at least one of:i. vacuum depositing a layer of material onto the at least one surface, wherein the vacuum deposited layer is different from the at least one surface immediately therebeneath in a material property selected from the group of material properties consisting of: grain size, grain phase, grain material composition, surface topography, and transition temperature, and removing the mask to yield a plurality of binding domains defined on the at least one surface of the implantable, biocompatible material; andii. vacuum depositing a layer of sacrificial material onto the at least one surface, removing the mask from the at least one surface, vacuum depositing a second layer of material onto the at least one surface, wherein the second vacuum deposited layer is different from the at least one surface immediately therebeneath in a material property selected from the group of material properties consisting of: grain size, grain phase, grain material composition, surface topography, and transition temperature, and removing the sacrificial material to yield a plurality of binding domains defined on the at least one surface of the implantable, biocompatible material. 2. The method of claim 1, wherein the implantable, biocompatible material in the providing step comprises a bulk material. 3. The method of claim 1, wherein the implantable, biocompatible material in the providing step comprises one or more layers of vacuum deposited biocompatible materials. 4. The method of claim 1, wherein a gap distance measured between immediately adjacent openings in the mask measures between about 1 nanometer and about 2000 nanometers, wherein the gap distance measures about the same as a width of each of the openings, and wherein the mask has a thickness between about 1 nm and about 3 μm. 5. The method of claim 1, further including the step of activating the at least one surface of the implantable, biocompatible material by removing contaminant molecules that occupy otherwise unsaturated bonds at the at least one surface. 6. The method of claim 5, wherein the activating step further comprises activating the at least one surface of the implantable, biocompatible material by a technique for activation selected from the techniques for activation of the at least one surface consisting of: chemical etching, electrochemical treatment, thermal treatment, and plasma etching. 7. The method of claim 5, further including the step of preserving the activation of the at least one surface prior to implantation. 8. The method of claim 7, wherein the preserving step further includes coating the activated at least one surface subsequent to activation thereof with a biodegradable material that dissolves upon exposure to an in vivo environment. 9. The method of claim 7, wherein the preserving step further includes coating the activated at least one surface subsequent to activation thereof with a biodegradable material.
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