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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0066347 (2011-04-11) |
| 등록번호 | US-9277955 (2016-03-08) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 2 인용 특허 : 1065 |
Apparatus, systems, and methods are provided for the generation and control of energy delivery in a dosage to elicit a therapeutic response in diseased tissue. A balloon catheter can have electrodes attached to a power generator and controller such that the balloon and electrodes contact tissue duri
Apparatus, systems, and methods are provided for the generation and control of energy delivery in a dosage to elicit a therapeutic response in diseased tissue. A balloon catheter can have electrodes attached to a power generator and controller such that the balloon and electrodes contact tissue during energy treatment. Energy selectively may be applied to tissue based on measured impedance to achieve gentle heating. Calibration of the apparatus and identification of attached accessories by computing the circuit impedance prior to energy dosage facilitate regulation of power delivery about a set point. Energy delivery can be controlled to achieve substantially uniform bulk tissue temperature distribution. Energy delivery may beneficially affect nerve activity.
1. A power generating apparatus for treatment of tissue having a circuit comprising: a direct digital synthesizer (DDS) operatively coupled to a power amplifier;a power output set point controller providing a signal;a peak effective power sensor receiving voltage and current feedback measured during
1. A power generating apparatus for treatment of tissue having a circuit comprising: a direct digital synthesizer (DDS) operatively coupled to a power amplifier;a power output set point controller providing a signal;a peak effective power sensor receiving voltage and current feedback measured during delivery of power from the circuit to a power delivery target, the peak effective power sensor providing a signal based on the feedback; anda PID controller, operatively coupled to receive the signals from the power output set point controller and the peak effective power sensor, and operatively coupled to direct a modulating voltage signal to the power amplifier such that output of power from the circuit is maintained within a range about a power output set point in response to the signal from the peak effective power sensor, wherein the output of power from the circuit is continuously maintained during a treatment period,wherein the power amplifier is comprised of a variable gain amplifier and a linear power amplifier operatively coupled in series. 2. The power generating apparatus of claim 1 wherein a digital-to-analog converter is coupled between the DDS and power amplifier. 3. The power generating apparatus of claim 1 wherein energy output is RF energy. 4. The power generating apparatus of claim 1 wherein the power delivery target is comprised of tissue. 5. The power generating apparatus of claim 1 wherein the DDS, power output set point controller, and peak effective power sensor comprise a field programmable gate array. 6. The power generating apparatus of claim 1 wherein the power amplifier is comprised of a linear power amplifier whose maximum output voltage is controlled by the current flowing in the power amplifier. 7. The power generating apparatus of claim 6 wherein output voltage from the linear power amplifier to the power delivery target during use comprises RF output voltage having a maximum available output limit over a range of load impedances of about 50 Ohm to about 500 Ohms. 8. The power generating apparatus of claim 6 wherein the maximum output voltage from the linear power amplifier limits the power dissipation within the power amplifier. 9. The power generating apparatus of claim 6 wherein the linear power amplifier controls the maximum output voltage using switched mode technology. 10. The power generating apparatus of claim 1 wherein the modulating voltage signal from the PID controller is received by the variable gain amplifier. 11. The power generating apparatus of claim 1 wherein the peak effective power sensor comprises a DDS, a current circuit further comprising square root and inverse tangent gates in parallel, and a voltage circuit further comprising square root and inverse tangent gates in parallel. 12. The power generating apparatus of claim 11 wherein the DDS of the peak effective power sensor has a voltage output with a low-pass filter, and a current output with a low-pass filter. 13. The power generating apparatus of claim 11 wherein output of the inverse tangent gates for the current circuit and the voltage circuit are operatively coupled to pass through a cosine gate. 14. The power generating apparatus of claim 1 wherein the voltage and current feedback from the power delivery target to the peak effective power sensor each comprise in-phase and quadrature signal components. 15. The power generating apparatus of claim 1 wherein the signal from the peak effective power sensor represents the effective power output of the circuit at the power delivery target. 16. The power generating apparatus of claim 1 wherein the power output set point is about 0.001 Watts to about 50 Watts. 17. The power generating apparatus of claim 1 wherein the power output modulates about the set point by a maximum of about ±20%. 18. The power generating apparatus of claim 1 wherein the power output modulates about the set point by a maximum of about ±10%. 19. The power generating apparatus of claim 1 wherein the power output modulates about the set point by a maximum of about ±5%. 20. The power generating apparatus of claim 1 wherein the power output modulates about the set point by a maximum of about ±2%. 21. A power generating apparatus for treatment of tissue comprising: a DDS operatively coupled to a RF power amplifier;a RF power output set point controller providing a signal;a peak effective RF power sensor receiving voltage and current feedback measured at a RF power delivery target during RF power delivery to the power delivery target, the peak effective RF power sensor providing a signal based on the feedback; anda controller, operatively coupled to receive the signals from the RF power output set point controller and the peak effective RF power sensor, and operatively coupled to direct a modulating voltage signal to the RF power amplifier such that the output of RF power from the circuit is maintained within a range about the RF power output set point in response to the signal provided by the peak effective RF power sensor, wherein the output of RF power from the circuit is continuously maintained during a treatment period,wherein the power amplifier is comprised of a variable gain amplifier and a linear power amplifier operatively coupled in series. 22. A power generating and control apparatus for eccentric remodeling treatment of tissue about a lumen, the apparatus comprising: a DDS operatively coupled to a RF power amplifier;a RF power output set point controller providing a signal;a peak effective RF power sensor receiving voltage and current feedback measured at the tissue during RF power delivery about the circumference of the lumen, the peak effective RF power sensor providing a signal based on the feedback; anda controller, operatively coupled to receive the signals from the RF power output set point controller and the peak effective RF power sensor, and operatively coupled to direct a modulating voltage signal to the RF power amplifier such that the output of RF power from the circuit is maintained within a therapeutic tissue remodeling range about the RF power output set point in response to the signal provided by the peak effective RF power sensor, wherein the output of RF power from the circuit is continuously maintained during a treatment period,wherein the power amplifier is comprised of a variable gain amplifier and a linear power amplifier operatively coupled in series. 23. A power generating apparatus for treatment of a target tissue, the power generating apparatus comprising: a frequency synthesizer generating a frequency signal;a power amplifier operatively coupling the frequency synthesizer to a power output, the output coupleable to the target tissue;a power sensor configured to receive voltage and current feedback from the target tissue during power output delivery to the target tissue and to output a signal based on the voltage and current feedback; anda controller coupling the power sensor to the power amplifier, the controller having an input for receiving a power set point and transmitting, in response to the power set point and the signal from the power sensor, a modulating signal to the power amplifier such that power output from the power amplifier to the target tissue per the frequency signal is maintained within a range about the power set point, wherein the output of power from the power amplifier is continuously maintained during a treatment period,wherein the power amplifier is comprised of a variable gain amplifier and a linear power amplifier operatively coupled in series. 24. The power generating apparatus of claim 23 wherein the frequency synthesizer comprises a digital frequency synthesizer, and wherein a digital-to-analog converter couples the frequency synthesizer to the power amplifier. 25. The power generating apparatus of claim 23 wherein energy output to the target comprises RF energy.
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