최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0174752 (2008-07-17) |
등록번호 | US-9284409 (2016-03-15) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 437 |
In embodiments, medical devices have a surface that includes a catalytic material, and a non-fouling material attached to the surface. The non-fouling material can be released from the surface, for example, by cleavage of a bond connecting the material to the surface. The bond can be a chemical bond
In embodiments, medical devices have a surface that includes a catalytic material, and a non-fouling material attached to the surface. The non-fouling material can be released from the surface, for example, by cleavage of a bond connecting the material to the surface. The bond can be a chemical bond, such as a covalent bond.
1. An endoprosthesis, comprising: a surface comprising a catalytic material, anda non-fouling material attached to the surface, wherein the material reduces adsorption of a protein to the surface and has a preferentially cleavable link connecting the material to the surface. 2. The endoprosthesis of
1. An endoprosthesis, comprising: a surface comprising a catalytic material, anda non-fouling material attached to the surface, wherein the material reduces adsorption of a protein to the surface and has a preferentially cleavable link connecting the material to the surface. 2. The endoprosthesis of claim 1, wherein the catalytic material catalyzes decomposition of H2O2. 3. The endoprosthesis of claim 1, wherein the catalytic material is a ceramic. 4. The endoprosthesis of claim 1, wherein the catalytic material comprises iridium oxide. 5. The endoprosthesis of claim 1, wherein the catalytic material is selected from titanium nitrate, and platinum activated carbon. 6. The endoprosthesis of claim 1, wherein the non-fouling material comprises a hydrophilic compound. 7. The endoprosthesis of claim 6, wherein the compound comprises a PEG. 8. The endoprosthesis of claim 7, wherein the PEG has a molecular weight of about 1,000 to about 50,000. 9. The endoprosthesis of claim 1, wherein the non-fouling material is releasable from the surface. 10. The endoprosthesis of claim 1, wherein the link is hydrolysable. 11. The endoprosthesis of claim 1, wherein the link is an ester bond. 12. The endoprosthesis of claim 1, wherein the non-fouling material forms a layer. 13. The endoprosthesis of claims 1, wherein the non-fouling material comprises a first block and a second block that is between the first block and the surface. 14. The endoprosthesis of claim 13, wherein the first block has a primary function of repelling proteins. 15. The endoprosthesis of claim 13, wherein the second block has a primary function of linkage as to connect the first block to the surface. 16. The endoprosthesis of claim 13, wherein the first and second blocks are connected by a preferentially cleavable link. 17. The endoprosthesis of claim 16, wherein the second block and the surface are connected by a preferentially cleavable link. 18. The endoprosthesis of claim 16, wherein the link is hydrolysable. 19. The endoprosthesis of claim 13, wherein the first block comprises a PEG and the second block comprises an aminosilane. 20. The endoprosthesis of claim 18, wherein the first block comprises a PEG and the second block comprises an aminosilane. 21. The endoprosthesis of claim 18, wherein the first block comprises a PEG and the second block comprises an endothelial cell binding agent. 22. The endoprosthesis of claim 20, wherein the second block further comprises an endothelial cell binding agent. 23. The endoprosthesis of claim 21, wherein the endothelial cell binding agent comprises an RGD peptide fragment. 24. A method of forming an endoprosthesis, comprising: coating a surface with a temporary non-fouling layer, the surface comprising a catalytic material, the layer reducing adsorption of a protein to the surface and allowing H2O2 to the surface. 25. The method of claim 24, wherein the surface comprises IROX. 26. The method of claim 24, wherein the non-fouling layer comprises a hydrophilic polymer. 27. The method of claim 24, further comprising modifying the surface with an aminosilane before coating the surface with the layer. 28. The method of claim 27, wherein the aminosilane is APTES. 29. The method of claim 27, wherein the layer comprises a hydrophilic polymer. 30. The method of claim 26, wherein the polymer has a hydrolysable link connecting the polymer to the surface. 31. The method of claim 29, wherein the polymer has a hydrolysable link connecting the polymer to the aminosilane. 32. The method of claim 24, further comprising modifying the surface with an endothelial cell binding agent before coating the surface with the layer. 33. The method of claim 32, wherein the endothelial cell binding agent comprises an RGD peptide segment. 34. The method of claim 32, wherein the layer comprises a hydrophilic polymer. 35. The method of claim 34, wherein the polymer has a hydrolysable link connecting the polymer to the endothelial cell binding agent.
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