초록 ▼

Sensors and detection systems suitable for measuring analytes, such as biomolecule, organic and inorganic species, including environmentally and medically relevant volatiles and gases, such as NO, NO2, CO2, NH3, H2, CO and the like, are provided. Certain embodiments of nanostructured sensor systems

Sensors and detection systems suitable for measuring analytes, such as biomolecule, organic and inorganic species, including environmentally and medically relevant volatiles and gases, such as NO, NO2, CO2, NH3, H2, CO and the like, are provided. Certain embodiments of nanostructured sensor systems are configured for measurement of medically important gases in breath. Applications include the measurement of endogenous nitric oxide (NO) in breath, such as for the monitoring or diagnosis of asthma and other pulmonary conditions.

대표청구항 ▼

1. A electrochemical sensor device for detecting an analyte species in a fluid sample medium, comprising: (a) a substrate having a substrate surface;(b) one or more nanostructures disposed over the substrate surface, the one or more nanostructures having functionalization materials specific to the a

1. A electrochemical sensor device for detecting an analyte species in a fluid sample medium, comprising: (a) a substrate having a substrate surface;(b) one or more nanostructures disposed over the substrate surface, the one or more nanostructures having functionalization materials specific to the analytic attached thereto;(c) one or more conducting elements in electrical communication with the nanostructure and configured to communicate with measurement circuitry; and(d) a layer coating at least a portion of the substrate surface, wherein the portion of the substrate surface and the nanostructures are differentially coated with said layer such that at least a portion of the nanostructures are exposed to permit interaction with the sample medium, wherein the layer inhibits at least one interaction between the substrate surface and the sample medium, so as to prevent or reduce at least one interference response of the device which would be detectable by the measurement circuitry via the one or more conducting elements in the absence of the layer, and wherein the coated portions of the substrate surface contacts the layer. 2. The electrochemical sensor device of claim 1 wherein at least a portion of one or more conducting elements are coated with said layer and said layer inhibits at least one interaction between the one or more conducting elements and the sample medium, so as to prevent or reduce at least one interference response which would be detectable by the measurement circuitry in the absence of the layer. 3. The electrochemical sensor device of claim 1 wherein the layer is deposited by an atomic layer deposition method. 4. The electrochemical sensor device of claim 1, wherein the layer has a thickness between about 1 nm and 10 nm. 5. The electrochemical sensor device of claim 1, wherein the layer has a thickness of less than 5 nm. 6. The electrochemical sensor device of claim 1, wherein the layer comprises one or both of Al2O3 or ZrO2. 7. The electrochemical sensor device of claim 1 wherein the layer inhibits oxidation of at least one of: the substrate surface, the one or more conducting elements, and the one or more nanostructures. 8. The electrochemical sensor device of claim 1 wherein the one or more nanostructures comprises a random network of carbon nanotubes. 9. The electrochemical sensor device of claim 1 wherein substantially all of the substrate surface in between nanostructures is coated with said layer. 10. The electrochemical sensor device of claim 1, wherein the functionalization material is disposed on the differential coating. 11. The electrochemical sensor device of claim 1, wherein the substrate is an organic material. 12. The electrochemical sensor device of claim 1, wherein the sensor is an electrochemical sensor. 13. The electrochemical sensor device of claim 1, wherein the one or more nanostructures are disposed over a carbon paste electrode.