A graft device is provided comprising a flow conduit and a surrounding covering. The graft device is for connecting between a first body space and a second body space. In one embodiment, the flow conduit is a vein, such as a harvested saphenous vein, useful as an arterial graft, for example and with
A graft device is provided comprising a flow conduit and a surrounding covering. The graft device is for connecting between a first body space and a second body space. In one embodiment, the flow conduit is a vein, such as a harvested saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided are methods of preparing a graft device and connecting the graft between a first body space and a second body space, such as the aorta and a location on an occluded coronary artery, distal to the occlusion.
대표청구항▼
1. A method of creating a graft device for a patient the method comprising: shaping a mandrel based on one or more geometric parameters of a patient image; placing a living tubular conduit harvested from the patient over the shaped mandrel; applying a covering over the living tubular conduit to form
1. A method of creating a graft device for a patient the method comprising: shaping a mandrel based on one or more geometric parameters of a patient image; placing a living tubular conduit harvested from the patient over the shaped mandrel; applying a covering over the living tubular conduit to form the graft device; andremoving the shaped mandrel from the graft device,wherein the graft device comprises the one or more geometric parameters of the patient image. 2. The method of claim 1, wherein the living tubular conduit comprises an eustachian tube, an artery, a vein, a urethra, an intestine, an esophagus, a ureter, a trachea, a fallopian tube, or combinations thereof. 3. The method of claim 1, wherein the patient image is produced by an instrument comprising X-ray, MRI, Ct-Scan; NMR, Ultrasound, CCD Camera, film camera, or combinations thereof. 4. The method of claim 1, wherein a cross section of the graft device varies from a proximal end to a distal end. 5. The method of claim 1, wherein the covering comprises a polymer. 6. The method of claim 1, wherein the applying comprises electrospinning a fiber matrix over the living tubular conduit. 7. The method of claim 6, wherein the electrospun fiber matrix comprises a polymer. 8. The method of claim 1, wherein the applying comprises performing multiple passes along the living tubular conduit. 9. The method of claim 1, wherein the covering resists radial expansion of the living tubular conduit. 10. The method of claim 1, wherein the covering initially allows radial expansion of the living tubular conduit and subsequently resists radial expansion of the living tubular conduit. 11. The method of claim 10, wherein the initial radial expansion occurs during the applying. 12. The method of claim 1, further comprising attaching the graft device between an aorta and a coronary artery of the patient. 13. The method of claim 1, wherein the shaped mandrel comprises a conductive material. 14. The method of claim 1, wherein the shaped mandrel is plastically deformable. 15. The method of claim 1, wherein the shaped mandrel transitions one or more times between flexible and rigid configurations. 16. The method of claim 1, wherein the shaped mandrel comprises a non-circular cross section. 17. The method of claim 1, wherein the patient image is of an anastomotic connection site. 18. The method of claim 1, wherein the patient image is of an anatomical area proximate to an aorta and one or more occluded arteries. 19. The method of claim 1, wherein the patient image is obtained from a visualization procedure on the patient. 20. The method of claim 1, wherein the patient image is obtained prior to or during a surgical procedure. 21. The method of claim 1, wherein the one or more geometric parameters comprise a length, a shape, a diameter, or combinations thereof. 22. The method of claim 1, wherein the covering is a restrictive covering or a constrictive covering. 23. The method of claim 1, further comprising collapsing the shaped mandrel before the removing. 24. The method of claim 23, wherein the shaped mandrel comprises an inner portion and an outer portion and wherein the inner portion of the shaped mandrel is removed before collapsing the outer portion of the shaped mandrel.
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